Impairment of the Hypothalamus–Pituitary–Thyroid Axis Caused by Naturally Occurring <i>GATA2</i> Mutations In Vitro

Impairment of the Hypothalamus–Pituitary–Thyroid Axis Caused by Naturally Occurring <i>GATA2</i> Mutations In Vitro

The transcription factor GATA2 regulates gene expression in several cells and tissues, including hematopoietic tissues and the central nervous system. Recent studies revealed that loss-of-function mutations in <i>GATA2</i> are associated with hematological disorders. Our earlier in vitro...

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Bibliographic Details
Main Authors:	Yuki Sakai, Kenji Ohba, Shigekazu Sasaki, Akio Matsushita, Hiroko Misawa Nakamura, Go Kuroda, Daisuke Tsuriya, Miho Yamashita, Takafumi Suda
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Series:	International Journal of Molecular Sciences
Subjects:	GATA thyroid central hypothyroidism hypothalamus–pituitary–thyroid axis (HPT axis) haploinsufficiency
Online Access:	https://www.mdpi.com/1422-0067/22/18/10015

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