Transcriptomic profiling of trichloroethylene exposure in male mouse liver
Chronic Trichloroethylene (TCE) exposure could induce hepatocellular carcinoma in mice, and occupational exposure in humans was suggested to be associated with liver cancer. To understand the role of non-genotoxic mechanism(s) for TCE action, we examined the gene expression and DNA methylation chang...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-03-01
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| Series: | Genomics Data |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213596015000045 |
| _version_ | 1818108775736803328 |
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| author | Yan Jiang Jiahong Chen Jian Tong Tao Chen |
| author_facet | Yan Jiang Jiahong Chen Jian Tong Tao Chen |
| author_sort | Yan Jiang |
| collection | DOAJ |
| description | Chronic Trichloroethylene (TCE) exposure could induce hepatocellular carcinoma in mice, and occupational exposure in humans was suggested to be associated with liver cancer. To understand the role of non-genotoxic mechanism(s) for TCE action, we examined the gene expression and DNA methylation changes in the liver of B6C3F1 mice orally administered with TCE for 5 days. As a beginning step, we profiled gene expression alterations induced by the TCE in mouse livers. Here we describe in detail the experimental methods, quality controls, and other information associated with our data deposited into Gene Expression Omnibus (GEO) under GSE58819. Our data provide useful information for gene expression responses to TCE in mouse liver. |
| first_indexed | 2024-12-11T02:20:43Z |
| format | Article |
| id | doaj.art-203fafa82b5549fa80245aa636536db4 |
| institution | Directory Open Access Journal |
| issn | 2213-5960 |
| language | English |
| last_indexed | 2024-12-11T02:20:43Z |
| publishDate | 2015-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Genomics Data |
| spelling | doaj.art-203fafa82b5549fa80245aa636536db42022-12-22T01:24:03ZengElsevierGenomics Data2213-59602015-03-013C14014210.1016/j.gdata.2015.01.002Transcriptomic profiling of trichloroethylene exposure in male mouse liverYan Jiang0Jiahong Chen1Jian Tong2Tao Chen3Department of Physiology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, ChinaDepartment of Toxicology, School of Public Health, Soochow University, Suzhou, ChinaDepartment of Toxicology, School of Public Health, Soochow University, Suzhou, ChinaDepartment of Toxicology, School of Public Health, Soochow University, Suzhou, ChinaChronic Trichloroethylene (TCE) exposure could induce hepatocellular carcinoma in mice, and occupational exposure in humans was suggested to be associated with liver cancer. To understand the role of non-genotoxic mechanism(s) for TCE action, we examined the gene expression and DNA methylation changes in the liver of B6C3F1 mice orally administered with TCE for 5 days. As a beginning step, we profiled gene expression alterations induced by the TCE in mouse livers. Here we describe in detail the experimental methods, quality controls, and other information associated with our data deposited into Gene Expression Omnibus (GEO) under GSE58819. Our data provide useful information for gene expression responses to TCE in mouse liver.http://www.sciencedirect.com/science/article/pii/S2213596015000045TrichloroethylenemRNALiverTumorMouse |
| spellingShingle | Yan Jiang Jiahong Chen Jian Tong Tao Chen Transcriptomic profiling of trichloroethylene exposure in male mouse liver Genomics Data Trichloroethylene mRNA Liver Tumor Mouse |
| title | Transcriptomic profiling of trichloroethylene exposure in male mouse liver |
| title_full | Transcriptomic profiling of trichloroethylene exposure in male mouse liver |
| title_fullStr | Transcriptomic profiling of trichloroethylene exposure in male mouse liver |
| title_full_unstemmed | Transcriptomic profiling of trichloroethylene exposure in male mouse liver |
| title_short | Transcriptomic profiling of trichloroethylene exposure in male mouse liver |
| title_sort | transcriptomic profiling of trichloroethylene exposure in male mouse liver |
| topic | Trichloroethylene mRNA Liver Tumor Mouse |
| url | http://www.sciencedirect.com/science/article/pii/S2213596015000045 |
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