Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast
Invasive micropapillary carcinoma (IMPC) is a highly metastatic rare form of breast cancer but its genomic alterations are largely unknown. Here, the authors show that monoclonal metastatic ancestors share copy-number loss of PRDM16 and IGSF9 and gain of ALDH2 in primary samples from IMPC patients.
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-27794-4 |
| _version_ | 1818753827622354944 |
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| author | Qianqian Shi Kang Shao Hongqin Jia Boyang Cao Weidong Li Shichen Dong Jian Liu Kailiang Wu Meng Liu Fangfang Liu Hanlin Zhou Jianke Lv Feng Gu Luyuan Li Shida Zhu Shuai Li Guibo Li Li Fu |
| author_facet | Qianqian Shi Kang Shao Hongqin Jia Boyang Cao Weidong Li Shichen Dong Jian Liu Kailiang Wu Meng Liu Fangfang Liu Hanlin Zhou Jianke Lv Feng Gu Luyuan Li Shida Zhu Shuai Li Guibo Li Li Fu |
| author_sort | Qianqian Shi |
| collection | DOAJ |
| description | Invasive micropapillary carcinoma (IMPC) is a highly metastatic rare form of breast cancer but its genomic alterations are largely unknown. Here, the authors show that monoclonal metastatic ancestors share copy-number loss of PRDM16 and IGSF9 and gain of ALDH2 in primary samples from IMPC patients. |
| first_indexed | 2024-12-18T05:13:33Z |
| format | Article |
| id | doaj.art-2040030032934025952e6d69d250090d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T05:13:33Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2040030032934025952e6d69d250090d2022-12-21T21:19:49ZengNature PortfolioNature Communications2041-17232022-01-0113111510.1038/s41467-021-27794-4Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breastQianqian Shi0Kang Shao1Hongqin Jia2Boyang Cao3Weidong Li4Shichen Dong5Jian Liu6Kailiang Wu7Meng Liu8Fangfang Liu9Hanlin Zhou10Jianke Lv11Feng Gu12Luyuan Li13Shida Zhu14Shuai Li15Guibo Li16Li Fu17Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and HospitalBGI-ShenzhenDepartment of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and HospitalBGI-ShenzhenDepartment of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and HospitalBGI-ShenzhenDepartment of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and HospitalDepartment of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and HospitalBGI-ShenzhenDepartment of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and HospitalBGI-ShenzhenDepartment of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and HospitalDepartment of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and HospitalState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai UniversityBGI-ShenzhenDepartment of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and HospitalBGI-ShenzhenDepartment of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and HospitalInvasive micropapillary carcinoma (IMPC) is a highly metastatic rare form of breast cancer but its genomic alterations are largely unknown. Here, the authors show that monoclonal metastatic ancestors share copy-number loss of PRDM16 and IGSF9 and gain of ALDH2 in primary samples from IMPC patients.https://doi.org/10.1038/s41467-021-27794-4 |
| spellingShingle | Qianqian Shi Kang Shao Hongqin Jia Boyang Cao Weidong Li Shichen Dong Jian Liu Kailiang Wu Meng Liu Fangfang Liu Hanlin Zhou Jianke Lv Feng Gu Luyuan Li Shida Zhu Shuai Li Guibo Li Li Fu Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast Nature Communications |
| title | Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast |
| title_full | Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast |
| title_fullStr | Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast |
| title_full_unstemmed | Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast |
| title_short | Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast |
| title_sort | genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast |
| url | https://doi.org/10.1038/s41467-021-27794-4 |
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