Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast

Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast

Invasive micropapillary carcinoma (IMPC) is a highly metastatic rare form of breast cancer but its genomic alterations are largely unknown. Here, the authors show that monoclonal metastatic ancestors share copy-number loss of PRDM16 and IGSF9 and gain of ALDH2 in primary samples from IMPC patients.

Bibliographic Details
Main Authors: Qianqian Shi, Kang Shao, Hongqin Jia, Boyang Cao, Weidong Li, Shichen Dong, Jian Liu, Kailiang Wu, Meng Liu, Fangfang Liu, Hanlin Zhou, Jianke Lv, Feng Gu, Luyuan Li, Shida Zhu, Shuai Li, Guibo Li, Li Fu
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-27794-4

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