Enzyme replacement therapy for pancreatic insufficiency: present and future
Aaron Fieker1, Jessica Philpott1, Martine Armand21Division of Digestive Diseases, University of Oklahoma, OKC, OK, USA; 2INSERM, U476 "Nutrition Humaine et Lipides", Marseille, F-13385 France; Univ Méditerranée Aix-Marseille 2, Facult&e...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2011-05-01
|
| Series: | Clinical and Experimental Gastroenterology |
| Online Access: | http://www.dovepress.com/enzyme-replacement-therapy-for-pancreatic-insufficiency-present-and-fu-a7345 |
| _version_ | 1828221754784350208 |
|---|---|
| author | Fieker A Philpott J Arm M |
| author_facet | Fieker A Philpott J Arm M |
| author_sort | Fieker A |
| collection | DOAJ |
| description | Aaron Fieker1, Jessica Philpott1, Martine Armand21Division of Digestive Diseases, University of Oklahoma, OKC, OK, USA; 2INSERM, U476 "Nutrition Humaine et Lipides", Marseille, F-13385 France; Univ Méditerranée Aix-Marseille 2, Faculté de Médecine, IPHM-IFR 125, Marseille, F-13385 FranceAbstract: Pancreatic enzyme replacement therapy is currently the mainstay of treatment for nutrient malabsorption secondary to pancreatic insufficiency. This treatment is safe and has few side effects. Data demonstrate efficacy in reducing steatorrhea and fat malabsorption. Effective therapy has been limited by the ability to replicate the physiologic process of enzyme delivery to the appropriate site, in general the duodenum, at the appropriate time. The challenges include enzyme destruction in the stomach, lack of adequate mixing with the chyme in the duodenum, and failing to deliver and activate at the appropriate time. Treatment is begun when clinically significant malabsorption occurs resulting in steatorrhea and weight loss. Treatment failure is addressed in a sequential fashion. Current research is aimed at studying new enzymes and delivery systems to improve the efficiency of action in the duodenum along with developing better means to monitor therapy.Keywords: exocrine pancreatic insufficiency, chronic pancreatitis, cystic fibrosis, pancreatic enzyme replacement therapy, lipase, lipids |
| first_indexed | 2024-04-12T16:45:55Z |
| format | Article |
| id | doaj.art-2040bef950334c379825788475e482de |
| institution | Directory Open Access Journal |
| issn | 1178-7023 |
| language | English |
| last_indexed | 2024-04-12T16:45:55Z |
| publishDate | 2011-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical and Experimental Gastroenterology |
| spelling | doaj.art-2040bef950334c379825788475e482de2022-12-22T03:24:34ZengDove Medical PressClinical and Experimental Gastroenterology1178-70232011-05-012011default5573Enzyme replacement therapy for pancreatic insufficiency: present and futureFieker APhilpott JArmMAaron Fieker1, Jessica Philpott1, Martine Armand21Division of Digestive Diseases, University of Oklahoma, OKC, OK, USA; 2INSERM, U476 "Nutrition Humaine et Lipides", Marseille, F-13385 France; Univ Méditerranée Aix-Marseille 2, Faculté de Médecine, IPHM-IFR 125, Marseille, F-13385 FranceAbstract: Pancreatic enzyme replacement therapy is currently the mainstay of treatment for nutrient malabsorption secondary to pancreatic insufficiency. This treatment is safe and has few side effects. Data demonstrate efficacy in reducing steatorrhea and fat malabsorption. Effective therapy has been limited by the ability to replicate the physiologic process of enzyme delivery to the appropriate site, in general the duodenum, at the appropriate time. The challenges include enzyme destruction in the stomach, lack of adequate mixing with the chyme in the duodenum, and failing to deliver and activate at the appropriate time. Treatment is begun when clinically significant malabsorption occurs resulting in steatorrhea and weight loss. Treatment failure is addressed in a sequential fashion. Current research is aimed at studying new enzymes and delivery systems to improve the efficiency of action in the duodenum along with developing better means to monitor therapy.Keywords: exocrine pancreatic insufficiency, chronic pancreatitis, cystic fibrosis, pancreatic enzyme replacement therapy, lipase, lipidshttp://www.dovepress.com/enzyme-replacement-therapy-for-pancreatic-insufficiency-present-and-fu-a7345 |
| spellingShingle | Fieker A Philpott J Arm M Enzyme replacement therapy for pancreatic insufficiency: present and future Clinical and Experimental Gastroenterology |
| title | Enzyme replacement therapy for pancreatic insufficiency: present and future |
| title_full | Enzyme replacement therapy for pancreatic insufficiency: present and future |
| title_fullStr | Enzyme replacement therapy for pancreatic insufficiency: present and future |
| title_full_unstemmed | Enzyme replacement therapy for pancreatic insufficiency: present and future |
| title_short | Enzyme replacement therapy for pancreatic insufficiency: present and future |
| title_sort | enzyme replacement therapy for pancreatic insufficiency present and future |
| url | http://www.dovepress.com/enzyme-replacement-therapy-for-pancreatic-insufficiency-present-and-fu-a7345 |
| work_keys_str_mv | AT fiekera enzymereplacementtherapyforpancreaticinsufficiencypresentandfuture AT philpottj enzymereplacementtherapyforpancreaticinsufficiencypresentandfuture AT arm enzymereplacementtherapyforpancreaticinsufficiencypresentandfuture AT m enzymereplacementtherapyforpancreaticinsufficiencypresentandfuture |