Antibiotic Hypersensitivity Mechanisms
Antibiotics are commonly prescribed to treat a variety of bacterial infections. As with all medications, hypersensitivity reactions may occur and clinicians should be able to recognize them accurately and recommend appropriate management. Antibiotic related hypersensitivity reactions may be one of f...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-08-01
|
| Series: | Pharmacy |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2226-4787/7/3/122 |
| _version_ | 1811187307400658944 |
|---|---|
| author | Jenana H. Maker Cassandra M. Stroup Vanthida Huang Stephanie F. James |
| author_facet | Jenana H. Maker Cassandra M. Stroup Vanthida Huang Stephanie F. James |
| author_sort | Jenana H. Maker |
| collection | DOAJ |
| description | Antibiotics are commonly prescribed to treat a variety of bacterial infections. As with all medications, hypersensitivity reactions may occur and clinicians should be able to recognize them accurately and recommend appropriate management. Antibiotic related hypersensitivity reactions may be one of four different types: Type I reactions, which are IgE mediated and may lead to anaphylaxis; Type II reactions that are antibody-mediated and may result in thrombocytopenia, neutropenia, or hemolytic anemia; Type III reaction that involves an immune complex formation such as vasculitis; and Type IV reactions that consist of four subtypes and typically include a rash of varying level of severity with or without systemic signs and symptoms. Herein, we describe the mechanisms of different types of allergic reactions to commonly prescribed antibiotics and offer recommendations for management. Further, we briefly refer to antibiotic reactions that mimic hypersensitivity reactions but are not immune mediated, such as pseudoallergies and serum sickness-like reactions. |
| first_indexed | 2024-04-11T14:01:14Z |
| format | Article |
| id | doaj.art-204235865e8844f3a4ca1bd0e9aa61f2 |
| institution | Directory Open Access Journal |
| issn | 2226-4787 |
| language | English |
| last_indexed | 2024-04-11T14:01:14Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmacy |
| spelling | doaj.art-204235865e8844f3a4ca1bd0e9aa61f22022-12-22T04:20:07ZengMDPI AGPharmacy2226-47872019-08-017312210.3390/pharmacy7030122pharmacy7030122Antibiotic Hypersensitivity MechanismsJenana H. Maker0Cassandra M. Stroup1Vanthida Huang2Stephanie F. James3Department of Pharmacy Practice, Thomas J Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USADepartment of Pharmacy Practice, School of Pharmacy, Rueckert-Hartman College of Health Professions, Regis University, Denver, CO 80221, USADepartment of Pharmacy Practice, College of Pharmacy-Glendale, Midwestern University, Glendale, AZ 85308, USADepartment of Pharmaceutical Sciences, School of Pharmacy, Rueckert-Hartman College of Health Professions, Regis University, Denver, CO 80221, USAAntibiotics are commonly prescribed to treat a variety of bacterial infections. As with all medications, hypersensitivity reactions may occur and clinicians should be able to recognize them accurately and recommend appropriate management. Antibiotic related hypersensitivity reactions may be one of four different types: Type I reactions, which are IgE mediated and may lead to anaphylaxis; Type II reactions that are antibody-mediated and may result in thrombocytopenia, neutropenia, or hemolytic anemia; Type III reaction that involves an immune complex formation such as vasculitis; and Type IV reactions that consist of four subtypes and typically include a rash of varying level of severity with or without systemic signs and symptoms. Herein, we describe the mechanisms of different types of allergic reactions to commonly prescribed antibiotics and offer recommendations for management. Further, we briefly refer to antibiotic reactions that mimic hypersensitivity reactions but are not immune mediated, such as pseudoallergies and serum sickness-like reactions.https://www.mdpi.com/2226-4787/7/3/122antimicrobialhypersensitivityantibioticallergyanaphylaxisType IType IIType IIIType IV |
| spellingShingle | Jenana H. Maker Cassandra M. Stroup Vanthida Huang Stephanie F. James Antibiotic Hypersensitivity Mechanisms Pharmacy antimicrobial hypersensitivity antibiotic allergy anaphylaxis Type I Type II Type III Type IV |
| title | Antibiotic Hypersensitivity Mechanisms |
| title_full | Antibiotic Hypersensitivity Mechanisms |
| title_fullStr | Antibiotic Hypersensitivity Mechanisms |
| title_full_unstemmed | Antibiotic Hypersensitivity Mechanisms |
| title_short | Antibiotic Hypersensitivity Mechanisms |
| title_sort | antibiotic hypersensitivity mechanisms |
| topic | antimicrobial hypersensitivity antibiotic allergy anaphylaxis Type I Type II Type III Type IV |
| url | https://www.mdpi.com/2226-4787/7/3/122 |
| work_keys_str_mv | AT jenanahmaker antibiotichypersensitivitymechanisms AT cassandramstroup antibiotichypersensitivitymechanisms AT vanthidahuang antibiotichypersensitivitymechanisms AT stephaniefjames antibiotichypersensitivitymechanisms |