Acute Systemic Response Of BDNF, Lactate and Cortisol to Strenuous Exercise Modalities in Healthy Untrained Women
Acute bouts of intense exercise increase lactate concentration, which in turn stimulates brain-derived neurotrophic factor (BDNF) production. Cortisol released during intense exercise might inhibit BDNF synthesis. This study examined the acute effects of 2 protocols of strenuous exercise on serum BD...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-12-01
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| Series: | Dose-Response |
| Online Access: | https://doi.org/10.1177/1559325820970818 |
| _version_ | 1818562699529814016 |
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| author | Patricia C. García-Suárez MSc Iván Rentería PhD José Moncada-Jiménez PhD Andrew C. Fry PhD Alberto Jiménez-Maldonado PhD |
| author_facet | Patricia C. García-Suárez MSc Iván Rentería PhD José Moncada-Jiménez PhD Andrew C. Fry PhD Alberto Jiménez-Maldonado PhD |
| author_sort | Patricia C. García-Suárez MSc |
| collection | DOAJ |
| description | Acute bouts of intense exercise increase lactate concentration, which in turn stimulates brain-derived neurotrophic factor (BDNF) production. Cortisol released during intense exercise might inhibit BDNF synthesis. This study examined the acute effects of 2 protocols of strenuous exercise on serum BDNF. Seventeen physically-active healthy females (Age = 20.0 ± 0.9 yr., BMI = 23.0 ± 2.6 kg/m 2 ) performed a strenuous cycle-ergometer graded exercise test (GXT) and a high-intensity interval training session (HIIT). Serum BDNF, serum cortisol, cortisol: BDNF ratio and blood lactate (BLa) were recorded at baseline and immediately following exercise. Although non-statistically significant, the HIIT session elicited a higher magnitude of change from baseline for BDNF ( d = 0.17) and cortisol ( d = 1.18) than after the GXT ( d = -0.26, and d = 0.82, respectively). An interaction was found between GXT and HIIT trials and measurements on BLa levels, with higher post-exertion values after HIIT than after GXT (p < 0.0001, η 2 = 0.650, 95%CI = 2.2, 5.2). The higher BLa levels did not raise circulating BDNF. The elevated cortisol levels may have overcome the effects of lactate on BDNF. However, the higher BLa induced by HIIT suggest that interval exercise modality on the long-term could be a feasible intervention to increase circulating peripheral BDNF, at least in untrained healthy women. |
| first_indexed | 2024-12-14T01:07:11Z |
| format | Article |
| id | doaj.art-20430226352d4d148ad867dae7d3f8de |
| institution | Directory Open Access Journal |
| issn | 1559-3258 |
| language | English |
| last_indexed | 2024-12-14T01:07:11Z |
| publishDate | 2020-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Dose-Response |
| spelling | doaj.art-20430226352d4d148ad867dae7d3f8de2022-12-21T23:22:55ZengSAGE PublishingDose-Response1559-32582020-12-011810.1177/1559325820970818Acute Systemic Response Of BDNF, Lactate and Cortisol to Strenuous Exercise Modalities in Healthy Untrained WomenPatricia C. García-Suárez MSc0Iván Rentería PhD1José Moncada-Jiménez PhD2Andrew C. Fry PhD3Alberto Jiménez-Maldonado PhD4 Facultad de Deportes Campus Ensenada, Universidad Autónoma de Baja California, Ensenada, México Facultad de Deportes Campus Ensenada, Universidad Autónoma de Baja California, Ensenada, México Human Movement Sciences Research Center, University of Costa Rica, San José, Costa Rica Department of Health, Sport, & Exercise Sciences, The University of Kansas, Lawrence, KS, USA Facultad de Deportes Campus Ensenada, Universidad Autónoma de Baja California, Ensenada, MéxicoAcute bouts of intense exercise increase lactate concentration, which in turn stimulates brain-derived neurotrophic factor (BDNF) production. Cortisol released during intense exercise might inhibit BDNF synthesis. This study examined the acute effects of 2 protocols of strenuous exercise on serum BDNF. Seventeen physically-active healthy females (Age = 20.0 ± 0.9 yr., BMI = 23.0 ± 2.6 kg/m 2 ) performed a strenuous cycle-ergometer graded exercise test (GXT) and a high-intensity interval training session (HIIT). Serum BDNF, serum cortisol, cortisol: BDNF ratio and blood lactate (BLa) were recorded at baseline and immediately following exercise. Although non-statistically significant, the HIIT session elicited a higher magnitude of change from baseline for BDNF ( d = 0.17) and cortisol ( d = 1.18) than after the GXT ( d = -0.26, and d = 0.82, respectively). An interaction was found between GXT and HIIT trials and measurements on BLa levels, with higher post-exertion values after HIIT than after GXT (p < 0.0001, η 2 = 0.650, 95%CI = 2.2, 5.2). The higher BLa levels did not raise circulating BDNF. The elevated cortisol levels may have overcome the effects of lactate on BDNF. However, the higher BLa induced by HIIT suggest that interval exercise modality on the long-term could be a feasible intervention to increase circulating peripheral BDNF, at least in untrained healthy women.https://doi.org/10.1177/1559325820970818 |
| spellingShingle | Patricia C. García-Suárez MSc Iván Rentería PhD José Moncada-Jiménez PhD Andrew C. Fry PhD Alberto Jiménez-Maldonado PhD Acute Systemic Response Of BDNF, Lactate and Cortisol to Strenuous Exercise Modalities in Healthy Untrained Women Dose-Response |
| title | Acute Systemic Response Of BDNF, Lactate and Cortisol to Strenuous Exercise Modalities in Healthy Untrained Women |
| title_full | Acute Systemic Response Of BDNF, Lactate and Cortisol to Strenuous Exercise Modalities in Healthy Untrained Women |
| title_fullStr | Acute Systemic Response Of BDNF, Lactate and Cortisol to Strenuous Exercise Modalities in Healthy Untrained Women |
| title_full_unstemmed | Acute Systemic Response Of BDNF, Lactate and Cortisol to Strenuous Exercise Modalities in Healthy Untrained Women |
| title_short | Acute Systemic Response Of BDNF, Lactate and Cortisol to Strenuous Exercise Modalities in Healthy Untrained Women |
| title_sort | acute systemic response of bdnf lactate and cortisol to strenuous exercise modalities in healthy untrained women |
| url | https://doi.org/10.1177/1559325820970818 |
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