A Preliminary microRNA Analysis of non Syndromic Thoracic Aortic Aneurysms
The development of thoracic aortic aneurysms (TAAs) involves a multifactorial process resulting in alterations of the structure and composition of the extracellular matrix (ECM). Recently, modifications in microRNA (miRNA) expression were implicated in the pathogenesis of TAA. This study presents a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2012-12-01
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| Series: | Balkan Journal of Medical Genetics |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/v10034-012-0019-6 |
| _version_ | 1797705304573476864 |
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| author | Patuzzo Cristina Pasquali A Trabetti E Malerba G Pignatii PF Tessari M Faggian G |
| author_facet | Patuzzo Cristina Pasquali A Trabetti E Malerba G Pignatii PF Tessari M Faggian G |
| author_sort | Patuzzo Cristina |
| collection | DOAJ |
| description | The development of thoracic aortic aneurysms (TAAs) involves a multifactorial process resulting in alterations of the structure and composition of the extracellular matrix (ECM). Recently, modifications in microRNA (miRNA) expression were implicated in the pathogenesis of TAA. This study presents a preliminary miRNA microarray analysis conducted on pooled ascending aorta RNAs obtained from non familial non syndromic TAA patients (five males and five females) compared to matched control pools. Ninety-nine differentially expressed miRNAs with >1.5-foldup- or down-regulation in TAAs compared to controls were identified, 16.0% of which were similarly regulated in the two sexes. Genes putatively targeted by differentially expressed miRNAs belonged preferentially to focal adhesion and adherens junction pathways. The results indicate an altered regulation of miRNA-mediated gene expression in the cellular interactions of aneurysmal aortic wall. |
| first_indexed | 2024-03-12T05:34:10Z |
| format | Article |
| id | doaj.art-204413fb069243719766d80995487d22 |
| institution | Directory Open Access Journal |
| issn | 1311-0160 |
| language | English |
| last_indexed | 2024-03-12T05:34:10Z |
| publishDate | 2012-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Balkan Journal of Medical Genetics |
| spelling | doaj.art-204413fb069243719766d80995487d222023-09-03T06:32:21ZengSciendoBalkan Journal of Medical Genetics1311-01602012-12-0115Supplement515510.2478/v10034-012-0019-6A Preliminary microRNA Analysis of non Syndromic Thoracic Aortic AneurysmsPatuzzo Cristina0Pasquali A1Trabetti E2Malerba G3Pignatii PF4Tessari M5Faggian G6Department of Life and Reproduction Sciences, University of Verona, Strada Le Grazie 8, 37134,Verona, ItalyDepartment of Life and Reproduction Sciences, University of Verona, Verona, ItalyDepartment of Life and Reproduction Sciences, University of Verona, Verona, ItalyDepartment of Life and Reproduction Sciences, University of Verona, Verona, ItalyDepartment of Life and Reproduction Sciences, University of Verona, Verona, ItalyDepartment of Surgery, University of Verona, Verona, ItalyDepartment of Surgery, University of Verona, Verona, ItalyThe development of thoracic aortic aneurysms (TAAs) involves a multifactorial process resulting in alterations of the structure and composition of the extracellular matrix (ECM). Recently, modifications in microRNA (miRNA) expression were implicated in the pathogenesis of TAA. This study presents a preliminary miRNA microarray analysis conducted on pooled ascending aorta RNAs obtained from non familial non syndromic TAA patients (five males and five females) compared to matched control pools. Ninety-nine differentially expressed miRNAs with >1.5-foldup- or down-regulation in TAAs compared to controls were identified, 16.0% of which were similarly regulated in the two sexes. Genes putatively targeted by differentially expressed miRNAs belonged preferentially to focal adhesion and adherens junction pathways. The results indicate an altered regulation of miRNA-mediated gene expression in the cellular interactions of aneurysmal aortic wall.https://doi.org/10.2478/v10034-012-0019-6adherens junctionfocal adhesionmicrornas (mirnas)thoracic aortic aneurysms (taas) |
| spellingShingle | Patuzzo Cristina Pasquali A Trabetti E Malerba G Pignatii PF Tessari M Faggian G A Preliminary microRNA Analysis of non Syndromic Thoracic Aortic Aneurysms Balkan Journal of Medical Genetics adherens junction focal adhesion micrornas (mirnas) thoracic aortic aneurysms (taas) |
| title | A Preliminary microRNA Analysis of non Syndromic Thoracic Aortic Aneurysms |
| title_full | A Preliminary microRNA Analysis of non Syndromic Thoracic Aortic Aneurysms |
| title_fullStr | A Preliminary microRNA Analysis of non Syndromic Thoracic Aortic Aneurysms |
| title_full_unstemmed | A Preliminary microRNA Analysis of non Syndromic Thoracic Aortic Aneurysms |
| title_short | A Preliminary microRNA Analysis of non Syndromic Thoracic Aortic Aneurysms |
| title_sort | preliminary microrna analysis of non syndromic thoracic aortic aneurysms |
| topic | adherens junction focal adhesion micrornas (mirnas) thoracic aortic aneurysms (taas) |
| url | https://doi.org/10.2478/v10034-012-0019-6 |
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