Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for Survival in a Large Cohort Study of Male Laryngeal Squamous Carcinoma
Objective: High levels of red cell distribution width (RDW) may be associated with adverse outcomes in patients with cancer. The purpose of the present study was to investigate the prognostic impact of pretreatment RDW levels on overall survival (OS), cancer-specific survival (CSS), and disease-free...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.00271/full |
| _version_ | 1818970853008736256 |
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| author | Chi-Yao Hsueh Chi-Yao Hsueh Hui-Ching Lau Hui-Ching Lau Shengjie Li Lei Tao Lei Tao Ming Zhang Ming Zhang Hongli Gong Hongli Gong Liang Zhou Liang Zhou |
| author_facet | Chi-Yao Hsueh Chi-Yao Hsueh Hui-Ching Lau Hui-Ching Lau Shengjie Li Lei Tao Lei Tao Ming Zhang Ming Zhang Hongli Gong Hongli Gong Liang Zhou Liang Zhou |
| author_sort | Chi-Yao Hsueh |
| collection | DOAJ |
| description | Objective: High levels of red cell distribution width (RDW) may be associated with adverse outcomes in patients with cancer. The purpose of the present study was to investigate the prognostic impact of pretreatment RDW levels on overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS) in a large cohort of male laryngeal squamous cell cancer (LSCC) patients.Methods: A total of 809 LSCC patients who were treated between 2007 and 2011 at the Eye & ENT Hospital of Fudan University were enrolled and evaluated retrospectively. OS, CSS, and DFS were analyzed using the Kaplan–Meier method. To evaluate the prognostic significance of RDW levels, univariate, and multivariate Cox analyses were applied.Results: Higher pretreatment RDW levels were significantly associated with high death events, red blood cell count, hemoglobin, radiotherapy, operation therapy, and advanced tumor stage (p < 0.05). From the univariate analysis, we observed that the higher (13.2–13.5%) and the highest (>13.5%) quartiles of RDW level were consistent factors for poor OS, CSS, and DFS in LSCC patients. In the multivariate analysis, after adjusting for confounding factors, the higher and highest quartiles of RDW levels were identified as independent prognostic factors in male LSCC patients.Conclusion: Higher pretreatment RDW levels were demonstrated to be associated with poor clinical outcome in male LSCC patients and might be novel markers for patient stratification in LSCC management. |
| first_indexed | 2024-12-20T14:43:04Z |
| format | Article |
| id | doaj.art-2044be2d83c0408898c2758516074c57 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-20T14:43:04Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2044be2d83c0408898c2758516074c572022-12-21T19:37:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-04-01910.3389/fonc.2019.00271442428Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for Survival in a Large Cohort Study of Male Laryngeal Squamous CarcinomaChi-Yao Hsueh0Chi-Yao Hsueh1Hui-Ching Lau2Hui-Ching Lau3Shengjie Li4Lei Tao5Lei Tao6Ming Zhang7Ming Zhang8Hongli Gong9Hongli Gong10Liang Zhou11Liang Zhou12Department of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, ChinaShanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, ChinaDepartment of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, ChinaShanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, ChinaDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, ChinaShanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, ChinaDepartment of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, ChinaShanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, ChinaDepartment of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, ChinaShanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, ChinaDepartment of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, ChinaShanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, ChinaObjective: High levels of red cell distribution width (RDW) may be associated with adverse outcomes in patients with cancer. The purpose of the present study was to investigate the prognostic impact of pretreatment RDW levels on overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS) in a large cohort of male laryngeal squamous cell cancer (LSCC) patients.Methods: A total of 809 LSCC patients who were treated between 2007 and 2011 at the Eye & ENT Hospital of Fudan University were enrolled and evaluated retrospectively. OS, CSS, and DFS were analyzed using the Kaplan–Meier method. To evaluate the prognostic significance of RDW levels, univariate, and multivariate Cox analyses were applied.Results: Higher pretreatment RDW levels were significantly associated with high death events, red blood cell count, hemoglobin, radiotherapy, operation therapy, and advanced tumor stage (p < 0.05). From the univariate analysis, we observed that the higher (13.2–13.5%) and the highest (>13.5%) quartiles of RDW level were consistent factors for poor OS, CSS, and DFS in LSCC patients. In the multivariate analysis, after adjusting for confounding factors, the higher and highest quartiles of RDW levels were identified as independent prognostic factors in male LSCC patients.Conclusion: Higher pretreatment RDW levels were demonstrated to be associated with poor clinical outcome in male LSCC patients and might be novel markers for patient stratification in LSCC management.https://www.frontiersin.org/article/10.3389/fonc.2019.00271/fulllaryngeal squamous cell cancermalered cell distribution widthprognosisbiomarker |
| spellingShingle | Chi-Yao Hsueh Chi-Yao Hsueh Hui-Ching Lau Hui-Ching Lau Shengjie Li Lei Tao Lei Tao Ming Zhang Ming Zhang Hongli Gong Hongli Gong Liang Zhou Liang Zhou Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for Survival in a Large Cohort Study of Male Laryngeal Squamous Carcinoma Frontiers in Oncology laryngeal squamous cell cancer male red cell distribution width prognosis biomarker |
| title | Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for Survival in a Large Cohort Study of Male Laryngeal Squamous Carcinoma |
| title_full | Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for Survival in a Large Cohort Study of Male Laryngeal Squamous Carcinoma |
| title_fullStr | Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for Survival in a Large Cohort Study of Male Laryngeal Squamous Carcinoma |
| title_full_unstemmed | Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for Survival in a Large Cohort Study of Male Laryngeal Squamous Carcinoma |
| title_short | Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for Survival in a Large Cohort Study of Male Laryngeal Squamous Carcinoma |
| title_sort | pretreatment level of red cell distribution width as a prognostic indicator for survival in a large cohort study of male laryngeal squamous carcinoma |
| topic | laryngeal squamous cell cancer male red cell distribution width prognosis biomarker |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.00271/full |
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