Ultraviolet exposure regulates skin metabolome based on the microbiome
Abstract Skin metabolites (< 1500 Da) play a critical role in barrier function, hydration, immune response, microbial invasion, and allergen penetration. We aimed to understand the global metabolic profile changes of the skin in relation to the microbiome and UV exposure and exposed germ-free (de...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-34073-3 |
| _version_ | 1797832139642765312 |
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| author | Vijaykumar Patra Natalie Bordag Yohann Clement Harald Köfeler Jean-Francois Nicolas Marc Vocanson Sophie Ayciriex Peter Wolf |
| author_facet | Vijaykumar Patra Natalie Bordag Yohann Clement Harald Köfeler Jean-Francois Nicolas Marc Vocanson Sophie Ayciriex Peter Wolf |
| author_sort | Vijaykumar Patra |
| collection | DOAJ |
| description | Abstract Skin metabolites (< 1500 Da) play a critical role in barrier function, hydration, immune response, microbial invasion, and allergen penetration. We aimed to understand the global metabolic profile changes of the skin in relation to the microbiome and UV exposure and exposed germ-free (devoid of microbiome), disinfected mice (partially devoid of skin microbiome) and control mice with intact microbiome to immunosuppressive doses of UVB radiation. Targeted and untargeted lipidome and metabolome profiling was performed with skin tissue by high-resolution mass spectrometry. UV differentially regulated various metabolites such as alanine, choline, glycine, glutamine, and histidine in germ-free mice compared to control mice. Membrane lipid species such as phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were also affected by UV in a microbiome-dependent manner. These results shed light on the dynamics and interactions between the skin metabolome, microbiome, and UV exposure and open new avenues for the development of metabolite- or lipid-based applications to maintain skin health. |
| first_indexed | 2024-04-09T14:03:00Z |
| format | Article |
| id | doaj.art-2046ac0c88e942b3ac23b952cce2b6b2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T14:03:00Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2046ac0c88e942b3ac23b952cce2b6b22023-05-07T11:10:36ZengNature PortfolioScientific Reports2045-23222023-05-0113111010.1038/s41598-023-34073-3Ultraviolet exposure regulates skin metabolome based on the microbiomeVijaykumar Patra0Natalie Bordag1Yohann Clement2Harald Köfeler3Jean-Francois Nicolas4Marc Vocanson5Sophie Ayciriex6Peter Wolf7Department of Dermatology, Medical University of GrazDepartment of Dermatology, Medical University of GrazUniversité de Lyon, Université Claude Bernard Lyon 1, Institut des Sciences Analytiques, CNRS UMR 5280Core Facility for Mass Spectrometry, Medical University of GrazCentre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale, U1111, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique, UMR5308, Ecole Normale Supérieure de Lyon, Université de LyonCentre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale, U1111, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique, UMR5308, Ecole Normale Supérieure de Lyon, Université de LyonUniversité de Lyon, Université Claude Bernard Lyon 1, Institut des Sciences Analytiques, CNRS UMR 5280Department of Dermatology, Medical University of GrazAbstract Skin metabolites (< 1500 Da) play a critical role in barrier function, hydration, immune response, microbial invasion, and allergen penetration. We aimed to understand the global metabolic profile changes of the skin in relation to the microbiome and UV exposure and exposed germ-free (devoid of microbiome), disinfected mice (partially devoid of skin microbiome) and control mice with intact microbiome to immunosuppressive doses of UVB radiation. Targeted and untargeted lipidome and metabolome profiling was performed with skin tissue by high-resolution mass spectrometry. UV differentially regulated various metabolites such as alanine, choline, glycine, glutamine, and histidine in germ-free mice compared to control mice. Membrane lipid species such as phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were also affected by UV in a microbiome-dependent manner. These results shed light on the dynamics and interactions between the skin metabolome, microbiome, and UV exposure and open new avenues for the development of metabolite- or lipid-based applications to maintain skin health.https://doi.org/10.1038/s41598-023-34073-3 |
| spellingShingle | Vijaykumar Patra Natalie Bordag Yohann Clement Harald Köfeler Jean-Francois Nicolas Marc Vocanson Sophie Ayciriex Peter Wolf Ultraviolet exposure regulates skin metabolome based on the microbiome Scientific Reports |
| title | Ultraviolet exposure regulates skin metabolome based on the microbiome |
| title_full | Ultraviolet exposure regulates skin metabolome based on the microbiome |
| title_fullStr | Ultraviolet exposure regulates skin metabolome based on the microbiome |
| title_full_unstemmed | Ultraviolet exposure regulates skin metabolome based on the microbiome |
| title_short | Ultraviolet exposure regulates skin metabolome based on the microbiome |
| title_sort | ultraviolet exposure regulates skin metabolome based on the microbiome |
| url | https://doi.org/10.1038/s41598-023-34073-3 |
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