Research Progress in the Industrial Crystallization of Citrate—A Review
The citrate industry has a wide range of applications in food, pharmaceutical, and other fields. As a common class of food additives and functional supplements with tremendous development potential and strong core competitiveness, particles with good powder characteristics and functionalization are...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Crystals |
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| Online Access: | https://www.mdpi.com/2073-4352/13/8/1186 |
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| author | Yanyu Ma Xueyou Qin Hui Yan Junjie Li Chengwei Li Mingke Lian Xuemei Wei Runpu Shen Mingyang Chen Kangli Li Junbo Gong |
| author_facet | Yanyu Ma Xueyou Qin Hui Yan Junjie Li Chengwei Li Mingke Lian Xuemei Wei Runpu Shen Mingyang Chen Kangli Li Junbo Gong |
| author_sort | Yanyu Ma |
| collection | DOAJ |
| description | The citrate industry has a wide range of applications in food, pharmaceutical, and other fields. As a common class of food additives and functional supplements with tremendous development potential and strong core competitiveness, particles with good powder characteristics and functionalization are becoming one of the primary directions in the evolution of citrate into the high-end market. This article reviews the primary citrate crystallization techniques and examines the fundamental citrate crystallization mechanisms by describing citrate nucleation and growth during the industrial crystallization process. A variety of citrate hydrates are also summarized. The primary control conditions of the three essential product indices of purity, particle size, and grain shape are established. The need to take into account the density, fluidity, caking resistance, dissolution rate, suspension, bioavailability, and other indices of products is highlighted, along with applications for products that meet the purity and particle size requirements. While summarizing industrial citrate crystallization equipment, this paper also discusses the beneficial effect of continuous crystallization in achieving industrialization. Finally, the future development of citrate crystals is anticipated, and it is suggested that the combination of basic research and application research should be strengthened to explore the new application field of citrate crystals, and the automation and intelligence of the crystal preparation process should be realized as far as possible. |
| first_indexed | 2024-03-11T00:00:56Z |
| format | Article |
| id | doaj.art-2048b37b38e74cd6843b759a6bdcecaf |
| institution | Directory Open Access Journal |
| issn | 2073-4352 |
| language | English |
| last_indexed | 2024-03-11T00:00:56Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Crystals |
| spelling | doaj.art-2048b37b38e74cd6843b759a6bdcecaf2023-11-19T00:44:33ZengMDPI AGCrystals2073-43522023-07-01138118610.3390/cryst13081186Research Progress in the Industrial Crystallization of Citrate—A ReviewYanyu Ma0Xueyou Qin1Hui Yan2Junjie Li3Chengwei Li4Mingke Lian5Xuemei Wei6Runpu Shen7Mingyang Chen8Kangli Li9Junbo Gong10School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, ChinaSchool of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, ChinaSchool of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, ChinaSchool of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, ChinaRZBC(JUXIAN) Co., Ltd., Rizhao 276800, ChinaRZBC(JUXIAN) Co., Ltd., Rizhao 276800, ChinaZhejiang Engineering Research Center of Fat-Soluble Vitamin, Shaoxing University, Shaoxing 312000, ChinaZhejiang Engineering Research Center of Fat-Soluble Vitamin, Shaoxing University, Shaoxing 312000, ChinaSchool of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, ChinaInstitute of Shaoxing, Tianjin University, Shaoxing 312300, ChinaSchool of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, ChinaThe citrate industry has a wide range of applications in food, pharmaceutical, and other fields. As a common class of food additives and functional supplements with tremendous development potential and strong core competitiveness, particles with good powder characteristics and functionalization are becoming one of the primary directions in the evolution of citrate into the high-end market. This article reviews the primary citrate crystallization techniques and examines the fundamental citrate crystallization mechanisms by describing citrate nucleation and growth during the industrial crystallization process. A variety of citrate hydrates are also summarized. The primary control conditions of the three essential product indices of purity, particle size, and grain shape are established. The need to take into account the density, fluidity, caking resistance, dissolution rate, suspension, bioavailability, and other indices of products is highlighted, along with applications for products that meet the purity and particle size requirements. While summarizing industrial citrate crystallization equipment, this paper also discusses the beneficial effect of continuous crystallization in achieving industrialization. Finally, the future development of citrate crystals is anticipated, and it is suggested that the combination of basic research and application research should be strengthened to explore the new application field of citrate crystals, and the automation and intelligence of the crystal preparation process should be realized as far as possible.https://www.mdpi.com/2073-4352/13/8/1186citratescrystallization methodproduct indicatorscrystallizer |
| spellingShingle | Yanyu Ma Xueyou Qin Hui Yan Junjie Li Chengwei Li Mingke Lian Xuemei Wei Runpu Shen Mingyang Chen Kangli Li Junbo Gong Research Progress in the Industrial Crystallization of Citrate—A Review Crystals citrates crystallization method product indicators crystallizer |
| title | Research Progress in the Industrial Crystallization of Citrate—A Review |
| title_full | Research Progress in the Industrial Crystallization of Citrate—A Review |
| title_fullStr | Research Progress in the Industrial Crystallization of Citrate—A Review |
| title_full_unstemmed | Research Progress in the Industrial Crystallization of Citrate—A Review |
| title_short | Research Progress in the Industrial Crystallization of Citrate—A Review |
| title_sort | research progress in the industrial crystallization of citrate a review |
| topic | citrates crystallization method product indicators crystallizer |
| url | https://www.mdpi.com/2073-4352/13/8/1186 |
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