Dysregulation of PI3K/Akt/PTEN Pathway in Canine Mammary Tumor

Dysregulation of PI3K/Akt/PTEN Pathway in Canine Mammary Tumor

The PI3K/Akt/PTEN axis is one of the most important signaling pathways in tumorigenesis. Recently, mutation of PIK3CA has been highlighted due to the similarities of mutational hotspots in both dogs and humans. PIK3CA H1047R (c.3140A > G) has been discovered as the most common mutational hot spot...

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Bibliographic Details
Main Authors:	Soo-Hyeon Kim, Byung-Joon Seung, Seung-Hee Cho, Ha-Young Lim, Min-Kyung Bae, Jung-Hyang Sur
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Series:	Animals
Subjects:	dogs mammary neoplasms PI3K/Akt/PTEN pathway PIK3CA H1047R mutation
Online Access:	https://www.mdpi.com/2076-2615/11/7/2079

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