Perinatal Outcome of Singletons Born after Using a Simplified Low-Cost IVF Culture System and All Singletons Born in Flanders (Belgium) between 2012 and 2020
Background: We developed a simplified IVF culture system (SCS) which has proven to be effective and safe in a selected IVF cohort. Methods: Preterm birth (PTB) and low birth weight (LBW) of 175 singletons born after using the SCS, 104 after fresh embryo transfer (ET), and 71 after frozen embryo tran...
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MDPI AG
2023-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/11/3683 |
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| author | Willem Ombelet Régine Goemaes Elizaveta Fomenko Rudi Campo |
| author_facet | Willem Ombelet Régine Goemaes Elizaveta Fomenko Rudi Campo |
| author_sort | Willem Ombelet |
| collection | DOAJ |
| description | Background: We developed a simplified IVF culture system (SCS) which has proven to be effective and safe in a selected IVF cohort. Methods: Preterm birth (PTB) and low birth weight (LBW) of 175 singletons born after using the SCS, 104 after fresh embryo transfer (ET), and 71 after frozen embryo transfer, were compared with all singletons born in Flanders between 2012 and 2020 conceived after natural conception, ovarian stimulation (OS), and assisted reproduction (IVF/ICSI). Findings: The proportion of preterm (<37 weeks) births was significantly higher in the case of IVF or ICSI, followed by hormonal treatment, compared to spontaneous pregnancies. There was no significant difference in PTB between SCS and any of the other groups. Concerning the average birth weight we found no significant difference between singletons born after natural conception and SCS. However, a significant difference in average birth weight was found between SCS singletons and singletons born after IVF, ICSI and hormonal treatment, with a significantly higher birth weight in the SCS group. This difference was also observed in the proportion of babies weighing less than 2500 g, with significantly more LBW babies in the IVF and ICSI group compared to the SCS newborns. Interpretation: Taking into account the small series, PTB and LBW rates in SCS singletons were found to be comparable with singletons born after natural conception. Compared to babies born after ovarian stimulation and IVF/ICSI, SCS singletons had a lower PTB and LBW rates, although the differences were not significant for PTB. Our results confirm previous reports on reassuring perinatal outcomes after using the SCS technology. |
| first_indexed | 2024-03-11T03:03:18Z |
| format | Article |
| id | doaj.art-2049f94085d04c76b8ae44a2ae25f4dd |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T03:03:18Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2049f94085d04c76b8ae44a2ae25f4dd2023-11-18T08:05:00ZengMDPI AGJournal of Clinical Medicine2077-03832023-05-011211368310.3390/jcm12113683Perinatal Outcome of Singletons Born after Using a Simplified Low-Cost IVF Culture System and All Singletons Born in Flanders (Belgium) between 2012 and 2020Willem Ombelet0Régine Goemaes1Elizaveta Fomenko2Rudi Campo3Genk Institute for Fertility Technology, Department of Obstetrics and Gynaecology, ZOL Hospitals, 3600 Genk, BelgiumCentre for Perinatal Epidemiology (SPE), Koning Albert II-laan 35 Box 29, 1030 Brussels, BelgiumCentre for Perinatal Epidemiology (SPE), Koning Albert II-laan 35 Box 29, 1030 Brussels, BelgiumGenk Institute for Fertility Technology, Department of Obstetrics and Gynaecology, ZOL Hospitals, 3600 Genk, BelgiumBackground: We developed a simplified IVF culture system (SCS) which has proven to be effective and safe in a selected IVF cohort. Methods: Preterm birth (PTB) and low birth weight (LBW) of 175 singletons born after using the SCS, 104 after fresh embryo transfer (ET), and 71 after frozen embryo transfer, were compared with all singletons born in Flanders between 2012 and 2020 conceived after natural conception, ovarian stimulation (OS), and assisted reproduction (IVF/ICSI). Findings: The proportion of preterm (<37 weeks) births was significantly higher in the case of IVF or ICSI, followed by hormonal treatment, compared to spontaneous pregnancies. There was no significant difference in PTB between SCS and any of the other groups. Concerning the average birth weight we found no significant difference between singletons born after natural conception and SCS. However, a significant difference in average birth weight was found between SCS singletons and singletons born after IVF, ICSI and hormonal treatment, with a significantly higher birth weight in the SCS group. This difference was also observed in the proportion of babies weighing less than 2500 g, with significantly more LBW babies in the IVF and ICSI group compared to the SCS newborns. Interpretation: Taking into account the small series, PTB and LBW rates in SCS singletons were found to be comparable with singletons born after natural conception. Compared to babies born after ovarian stimulation and IVF/ICSI, SCS singletons had a lower PTB and LBW rates, although the differences were not significant for PTB. Our results confirm previous reports on reassuring perinatal outcomes after using the SCS technology.https://www.mdpi.com/2077-0383/12/11/3683assisted reproductioninfertilityIVFlow-cost IVFlow birth weightnatural conception |
| spellingShingle | Willem Ombelet Régine Goemaes Elizaveta Fomenko Rudi Campo Perinatal Outcome of Singletons Born after Using a Simplified Low-Cost IVF Culture System and All Singletons Born in Flanders (Belgium) between 2012 and 2020 Journal of Clinical Medicine assisted reproduction infertility IVF low-cost IVF low birth weight natural conception |
| title | Perinatal Outcome of Singletons Born after Using a Simplified Low-Cost IVF Culture System and All Singletons Born in Flanders (Belgium) between 2012 and 2020 |
| title_full | Perinatal Outcome of Singletons Born after Using a Simplified Low-Cost IVF Culture System and All Singletons Born in Flanders (Belgium) between 2012 and 2020 |
| title_fullStr | Perinatal Outcome of Singletons Born after Using a Simplified Low-Cost IVF Culture System and All Singletons Born in Flanders (Belgium) between 2012 and 2020 |
| title_full_unstemmed | Perinatal Outcome of Singletons Born after Using a Simplified Low-Cost IVF Culture System and All Singletons Born in Flanders (Belgium) between 2012 and 2020 |
| title_short | Perinatal Outcome of Singletons Born after Using a Simplified Low-Cost IVF Culture System and All Singletons Born in Flanders (Belgium) between 2012 and 2020 |
| title_sort | perinatal outcome of singletons born after using a simplified low cost ivf culture system and all singletons born in flanders belgium between 2012 and 2020 |
| topic | assisted reproduction infertility IVF low-cost IVF low birth weight natural conception |
| url | https://www.mdpi.com/2077-0383/12/11/3683 |
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