Mutated JAK2 signal transduction in human induced pluripotent stem cell (iPSC)-derived megakaryocytes

Mutated JAK2 signal transduction in human induced pluripotent stem cell (iPSC)-derived megakaryocytes

Janus kinase 2 (JAK2) gene mutations are the main drivers for polycythemia vera (PV) and essential thrombocythemia (ET). The mechanisms of single altered gene causing two different diseases are unclear. Additionally, novel treatments specifically targeting mutated JAK2 proteins are needed. In this s...

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Bibliographic Details
Main Authors: Jaturawat Pawinwongchai, Panchalee Jangprasert, Nungruthai Nilsri, Nipan Israsena, Ponlapat Rojnuckarin
Format: Article
Language:English
Published: Taylor & Francis Group 2022-07-01
Series:Platelets
Subjects:
interferon
ipscs
megakaryocytes
myeloproliferative neoplasms
signal transduction
Online Access:http://dx.doi.org/10.1080/09537104.2021.1981850

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