Food–Drug Interactions with Fruit Juices
Fruit juices contain a large number of phytochemicals that, in combination with certain drugs, can cause food–drug interactions that can be clinically significant and lead to adverse events. The mechanisms behind such interactions are in most cases related to phytochemical interference with the acti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/10/1/33 |
| _version_ | 1797543547568652288 |
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| author | Zvonimir Petric Irena Žuntar Predrag Putnik Danijela Bursać Kovačević |
| author_facet | Zvonimir Petric Irena Žuntar Predrag Putnik Danijela Bursać Kovačević |
| author_sort | Zvonimir Petric |
| collection | DOAJ |
| description | Fruit juices contain a large number of phytochemicals that, in combination with certain drugs, can cause food–drug interactions that can be clinically significant and lead to adverse events. The mechanisms behind such interactions are in most cases related to phytochemical interference with the activity of cytochrome P450 metabolizing enzymes (CYPs) or drug transporters. Moreover, alterations in their activity can have a clinical relevance if systemic exposure to the drug is decreased or increased, meaning that the pharmacological drug effects are suboptimal, or the drug will cause toxicity. In general, the common pharmacokinetic parameters found to be altered in food–drug interactions regarding fruit juices are the area under the concentration–time curve, bioavailability, and maximum plasma concentration. In most cases, the results from the drug interaction studies with fruit juices provide only limited information due to the small number of subjects, which are also healthy volunteers. Moreover, drug interactions with fruit juices are challenging to predict due to the unknown amounts of the specific phytochemicals responsible for the interaction, as well as due to the inter-individual variability of drug metabolism, among others. Therefore, this work aims to raise awareness about possible pharmacological interactions with fruit juices. |
| first_indexed | 2024-03-10T13:47:10Z |
| format | Article |
| id | doaj.art-204ca01509434be196647507b4ddd0b2 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T13:47:10Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-204ca01509434be196647507b4ddd0b22023-11-21T02:28:42ZengMDPI AGFoods2304-81582020-12-011013310.3390/foods10010033Food–Drug Interactions with Fruit JuicesZvonimir Petric0Irena Žuntar1Predrag Putnik2Danijela Bursać Kovačević3Unit of Pharmacokinetics and Drug Metabolism, Department of Pharmacology at the Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 40530 Göteborg, SwedenFaculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000 Zagreb, CroatiaDepartment of Food Technology, University North, Trg dr. Žarka Dolinara 1, 48000 Koprivnica, CroatiaFaculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, CroatiaFruit juices contain a large number of phytochemicals that, in combination with certain drugs, can cause food–drug interactions that can be clinically significant and lead to adverse events. The mechanisms behind such interactions are in most cases related to phytochemical interference with the activity of cytochrome P450 metabolizing enzymes (CYPs) or drug transporters. Moreover, alterations in their activity can have a clinical relevance if systemic exposure to the drug is decreased or increased, meaning that the pharmacological drug effects are suboptimal, or the drug will cause toxicity. In general, the common pharmacokinetic parameters found to be altered in food–drug interactions regarding fruit juices are the area under the concentration–time curve, bioavailability, and maximum plasma concentration. In most cases, the results from the drug interaction studies with fruit juices provide only limited information due to the small number of subjects, which are also healthy volunteers. Moreover, drug interactions with fruit juices are challenging to predict due to the unknown amounts of the specific phytochemicals responsible for the interaction, as well as due to the inter-individual variability of drug metabolism, among others. Therefore, this work aims to raise awareness about possible pharmacological interactions with fruit juices.https://www.mdpi.com/2304-8158/10/1/33fruit juiceinteractiondrugphytochemicalpharmacokinetics |
| spellingShingle | Zvonimir Petric Irena Žuntar Predrag Putnik Danijela Bursać Kovačević Food–Drug Interactions with Fruit Juices Foods fruit juice interaction drug phytochemical pharmacokinetics |
| title | Food–Drug Interactions with Fruit Juices |
| title_full | Food–Drug Interactions with Fruit Juices |
| title_fullStr | Food–Drug Interactions with Fruit Juices |
| title_full_unstemmed | Food–Drug Interactions with Fruit Juices |
| title_short | Food–Drug Interactions with Fruit Juices |
| title_sort | food drug interactions with fruit juices |
| topic | fruit juice interaction drug phytochemical pharmacokinetics |
| url | https://www.mdpi.com/2304-8158/10/1/33 |
| work_keys_str_mv | AT zvonimirpetric fooddruginteractionswithfruitjuices AT irenazuntar fooddruginteractionswithfruitjuices AT predragputnik fooddruginteractionswithfruitjuices AT danijelabursackovacevic fooddruginteractionswithfruitjuices |