STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury

STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury

Abstract Background Radiation-induced lung injury (RILI) is a prevalent complication of thoracic radiotherapy in cancer patients. A comprehensive understanding of the underlying mechanisms of RILI is essential for the development of effective prevention and treatment strategies. Methods To investiga...

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Bibliographic Details
Main Authors: Jianjiao Ni, Tiantian Guo, Yue Zhou, Shanshan Jiang, Long Zhang, Zhengfei Zhu
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Translational Medicine
Subjects:
Radiation-induced lung injury
cGAS-STING pathway
Macrophage polarization
Cytokine CCL2
Online Access:https://doi.org/10.1186/s12967-023-04446-3

Internet

https://doi.org/10.1186/s12967-023-04446-3

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