Differences in clinical characteristics and reported quality of life of men and women undergoing cardiac resynchronization therapy
Abstract Aims Response to cardiac resynchronization therapy (CRT) is known to be associated with a number of clinical characteristics, including QRS duration and morphology, gender, height, and the aetiology of heart failure (HF). We assessed the relation of gender and baseline characteristics with...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-10-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.12914 |
| _version_ | 1818734477752401920 |
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| author | Bruce L. Wilkoff David Birnie Michael R. Gold Ahmad S. Hersi Sandra Jacobs Bart Gerritse Kengo Kusano Christophe Leclercq Wilfried Mullens Gerasimos Filippatos |
| author_facet | Bruce L. Wilkoff David Birnie Michael R. Gold Ahmad S. Hersi Sandra Jacobs Bart Gerritse Kengo Kusano Christophe Leclercq Wilfried Mullens Gerasimos Filippatos |
| author_sort | Bruce L. Wilkoff |
| collection | DOAJ |
| description | Abstract Aims Response to cardiac resynchronization therapy (CRT) is known to be associated with a number of clinical characteristics, including QRS duration and morphology, gender, height, and the aetiology of heart failure (HF). We assessed the relation of gender and baseline characteristics with QRS duration and Kansas City Cardiomyopathy Questionnaire. Methods and results AdaptResponse is a global randomized trial. The trial enrolled CRT‐indicated patients with New York Heart Association classes II–IV HF, left bundle branch block (QRS ≥ 140 ms in men, ≥130 ms in women), and baseline PR interval ≤200 ms. In total, 3620 patients were randomized, including 1569 women (43.3%) approaching the actual proportion of women in the HF population. Women were older and more often New York Heart Association class III or IV than men (55.6% vs. 48.7%), had less frequent ischaemic cardiomyopathy (21.2% vs. 39.5%), and had a 5.1 ms shorter QRS duration than men. Women were more often depressed (18.5% vs. 9.7%), had a significantly lower Kansas City Cardiomyopathy Questionnaire score, and had differences in medication prescriptions. Conclusions AdaptResponse is the largest randomized CRT trial and enrolled more women than any other landmark CRT trial. Women differed from men with regard to baseline characteristics and quality of life. Whether these differences translate into clinical outcome differences will be examined further in the AdaptResponse trial. |
| first_indexed | 2024-12-18T00:05:59Z |
| format | Article |
| id | doaj.art-204dcf298dda4b32acfd52c9c1f7d5d7 |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-12-18T00:05:59Z |
| publishDate | 2020-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-204dcf298dda4b32acfd52c9c1f7d5d72022-12-21T21:27:47ZengWileyESC Heart Failure2055-58222020-10-01752972298210.1002/ehf2.12914Differences in clinical characteristics and reported quality of life of men and women undergoing cardiac resynchronization therapyBruce L. Wilkoff0David Birnie1Michael R. Gold2Ahmad S. Hersi3Sandra Jacobs4Bart Gerritse5Kengo Kusano6Christophe Leclercq7Wilfried Mullens8Gerasimos Filippatos9Cleveland Clinic Cleveland OH USAUniversity of Ottawa Heart Institute Ottawa Ontario CanadaDepartment of Cardiology Medical University of South Carolina Charleston SC USAFaculty of Medicine King Saud University Riyadh Saudi ArabiaMedtronic Bakken Research Center Maastricht The NetherlandsMedtronic Bakken Research Center Maastricht The NetherlandsNational Cerebral and Cardiovascular Center Osaka JapanDepartment of Cardiology University of Rennes Rennes FranceDepartment of Cardiology, Ziekenhuis Oost‐Limburg, Genk Belgium and Hasselt University Hasselt BelgiumSchool of Medicine National and Kapodistrian University of Athens Athens GreeceAbstract Aims Response to cardiac resynchronization therapy (CRT) is known to be associated with a number of clinical characteristics, including QRS duration and morphology, gender, height, and the aetiology of heart failure (HF). We assessed the relation of gender and baseline characteristics with QRS duration and Kansas City Cardiomyopathy Questionnaire. Methods and results AdaptResponse is a global randomized trial. The trial enrolled CRT‐indicated patients with New York Heart Association classes II–IV HF, left bundle branch block (QRS ≥ 140 ms in men, ≥130 ms in women), and baseline PR interval ≤200 ms. In total, 3620 patients were randomized, including 1569 women (43.3%) approaching the actual proportion of women in the HF population. Women were older and more often New York Heart Association class III or IV than men (55.6% vs. 48.7%), had less frequent ischaemic cardiomyopathy (21.2% vs. 39.5%), and had a 5.1 ms shorter QRS duration than men. Women were more often depressed (18.5% vs. 9.7%), had a significantly lower Kansas City Cardiomyopathy Questionnaire score, and had differences in medication prescriptions. Conclusions AdaptResponse is the largest randomized CRT trial and enrolled more women than any other landmark CRT trial. Women differed from men with regard to baseline characteristics and quality of life. Whether these differences translate into clinical outcome differences will be examined further in the AdaptResponse trial.https://doi.org/10.1002/ehf2.12914Cardiac resynchronization therapy outcomeLV pacingAV conductionLeft bundle branch blockGender differences in heart failureKansas City Cardiomyopathy Questionnaire |
| spellingShingle | Bruce L. Wilkoff David Birnie Michael R. Gold Ahmad S. Hersi Sandra Jacobs Bart Gerritse Kengo Kusano Christophe Leclercq Wilfried Mullens Gerasimos Filippatos Differences in clinical characteristics and reported quality of life of men and women undergoing cardiac resynchronization therapy ESC Heart Failure Cardiac resynchronization therapy outcome LV pacing AV conduction Left bundle branch block Gender differences in heart failure Kansas City Cardiomyopathy Questionnaire |
| title | Differences in clinical characteristics and reported quality of life of men and women undergoing cardiac resynchronization therapy |
| title_full | Differences in clinical characteristics and reported quality of life of men and women undergoing cardiac resynchronization therapy |
| title_fullStr | Differences in clinical characteristics and reported quality of life of men and women undergoing cardiac resynchronization therapy |
| title_full_unstemmed | Differences in clinical characteristics and reported quality of life of men and women undergoing cardiac resynchronization therapy |
| title_short | Differences in clinical characteristics and reported quality of life of men and women undergoing cardiac resynchronization therapy |
| title_sort | differences in clinical characteristics and reported quality of life of men and women undergoing cardiac resynchronization therapy |
| topic | Cardiac resynchronization therapy outcome LV pacing AV conduction Left bundle branch block Gender differences in heart failure Kansas City Cardiomyopathy Questionnaire |
| url | https://doi.org/10.1002/ehf2.12914 |
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