Chronic intracerebroventricular administration of dimethyl sulfoxide attenuates streptozotocin-iduced memory loss in rats
Background: The memory impairment, obtained from intracerebroventricular (i.c.v.) infusion of streptozotocin (STZ) in rats through activation of oxidative stress, is accepted as sporadic Alzheimer’s disease (AD) model in most experimental studies. Dimethyl sulfoxide (DMSO) as a solvent is widely use...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences and Health Services
2013-02-01
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| Series: | Research in Molecular Medicine |
| Subjects: | |
| Online Access: | http://rmm.mazums.ac.ir/browse.php?a_code=A-10-26-3&slc_lang=en&sid=1 |
| _version_ | 1829098853616320512 |
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| author | Esmaeil Akbari Nima Naderi Keyvan Yaghoobi Behzad Parsi Sahar Berijani |
| author_facet | Esmaeil Akbari Nima Naderi Keyvan Yaghoobi Behzad Parsi Sahar Berijani |
| author_sort | Esmaeil Akbari |
| collection | DOAJ |
| description | Background: The memory impairment, obtained from intracerebroventricular (i.c.v.) infusion of streptozotocin (STZ) in rats through activation of oxidative stress, is accepted as sporadic Alzheimer’s disease (AD) model in most experimental studies. Dimethyl sulfoxide (DMSO) as a solvent is widely used in animal studies to have antioxidant effects as well. However, no report is available about DMSO effect on oxidative stress-induced cognition deficit i.e. AD. The present work was designed to assess the effect of chronic treatment of DMSO on STZ-treated rats.
Materials and Methods: STZ (3 mg/ kg i.c.v. bilateral with 10 µl volume in either side days 1 and 3) using a single-day version of Morris water maze (MWM). The DMSO (2.5, 5 and 10 %v/v in saline), started from the first day, was infused for 14 days.
Results: The chronic administration of DMSO 10% (but not 2.5 and 5%) improved the distance to hidden platform (P<0.01) in training sessions and time spent in the target quadrant (P<0.01) in probe tests. Neither STZ nor DMSO had any intervention on velocity and visuo-motor coordination in the visible version of MWM.
Conclusion: Taken together, the results suggest that DMSO may be appropriate as adjuvant therapies for the prevention of memory impairment in the experimental models of AD. Therefore, use of DMSO as a solvent in AD animal studies should be considered having beneficial effects on cognitive function. |
| first_indexed | 2024-12-10T21:15:40Z |
| format | Article |
| id | doaj.art-204e7c6ad870474ab221e32d11322af7 |
| institution | Directory Open Access Journal |
| issn | 2322-1348 2322-133X |
| language | English |
| last_indexed | 2024-12-10T21:15:40Z |
| publishDate | 2013-02-01 |
| publisher | Mazandaran University of Medical Sciences and Health Services |
| record_format | Article |
| series | Research in Molecular Medicine |
| spelling | doaj.art-204e7c6ad870474ab221e32d11322af72022-12-22T01:33:19ZengMazandaran University of Medical Sciences and Health ServicesResearch in Molecular Medicine2322-13482322-133X2013-02-01112229Chronic intracerebroventricular administration of dimethyl sulfoxide attenuates streptozotocin-iduced memory loss in ratsEsmaeil Akbari0Nima Naderi1Keyvan Yaghoobi2Behzad Parsi3Sahar Berijani4 Background: The memory impairment, obtained from intracerebroventricular (i.c.v.) infusion of streptozotocin (STZ) in rats through activation of oxidative stress, is accepted as sporadic Alzheimer’s disease (AD) model in most experimental studies. Dimethyl sulfoxide (DMSO) as a solvent is widely used in animal studies to have antioxidant effects as well. However, no report is available about DMSO effect on oxidative stress-induced cognition deficit i.e. AD. The present work was designed to assess the effect of chronic treatment of DMSO on STZ-treated rats. Materials and Methods: STZ (3 mg/ kg i.c.v. bilateral with 10 µl volume in either side days 1 and 3) using a single-day version of Morris water maze (MWM). The DMSO (2.5, 5 and 10 %v/v in saline), started from the first day, was infused for 14 days. Results: The chronic administration of DMSO 10% (but not 2.5 and 5%) improved the distance to hidden platform (P<0.01) in training sessions and time spent in the target quadrant (P<0.01) in probe tests. Neither STZ nor DMSO had any intervention on velocity and visuo-motor coordination in the visible version of MWM. Conclusion: Taken together, the results suggest that DMSO may be appropriate as adjuvant therapies for the prevention of memory impairment in the experimental models of AD. Therefore, use of DMSO as a solvent in AD animal studies should be considered having beneficial effects on cognitive function.http://rmm.mazums.ac.ir/browse.php?a_code=A-10-26-3&slc_lang=en&sid=1Alzheimer’s disease dimethyl sulfoxide Morris water maze streptozotocin |
| spellingShingle | Esmaeil Akbari Nima Naderi Keyvan Yaghoobi Behzad Parsi Sahar Berijani Chronic intracerebroventricular administration of dimethyl sulfoxide attenuates streptozotocin-iduced memory loss in rats Research in Molecular Medicine Alzheimer’s disease dimethyl sulfoxide Morris water maze streptozotocin |
| title | Chronic intracerebroventricular administration of dimethyl sulfoxide attenuates streptozotocin-iduced memory loss in rats |
| title_full | Chronic intracerebroventricular administration of dimethyl sulfoxide attenuates streptozotocin-iduced memory loss in rats |
| title_fullStr | Chronic intracerebroventricular administration of dimethyl sulfoxide attenuates streptozotocin-iduced memory loss in rats |
| title_full_unstemmed | Chronic intracerebroventricular administration of dimethyl sulfoxide attenuates streptozotocin-iduced memory loss in rats |
| title_short | Chronic intracerebroventricular administration of dimethyl sulfoxide attenuates streptozotocin-iduced memory loss in rats |
| title_sort | chronic intracerebroventricular administration of dimethyl sulfoxide attenuates streptozotocin iduced memory loss in rats |
| topic | Alzheimer’s disease dimethyl sulfoxide Morris water maze streptozotocin |
| url | http://rmm.mazums.ac.ir/browse.php?a_code=A-10-26-3&slc_lang=en&sid=1 |
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