Current Status on Canine Foetal Fluid and Adnexa Derived Mesenchymal Stem Cells
Effective standards of care treatment guidelines have been developed for many canine diseases. However, a subpopulation of patients is partially or completely refractory to these protocols, so their owners seek novel therapies such as treatments with MSCs. Although in dogs, as with human medicine, t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/11/8/2254 |
| _version_ | 1797524959529009152 |
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| author | Eleonora Iacono Romina Marcoccia Barbara Merlo |
| author_facet | Eleonora Iacono Romina Marcoccia Barbara Merlo |
| author_sort | Eleonora Iacono |
| collection | DOAJ |
| description | Effective standards of care treatment guidelines have been developed for many canine diseases. However, a subpopulation of patients is partially or completely refractory to these protocols, so their owners seek novel therapies such as treatments with MSCs. Although in dogs, as with human medicine, the most studied MSCs sources have been bone marrow and adipose tissue, in recent years, many researchers have drawn attention towards alternative sources, such as foetal adnexa and fluid, since they possess many advantages over bone marrow and adipose tissue. Foetal adnexa and fluid could be considered as discarded material; therefore, sampling is non-invasive, inexpensive and free from ethical considerations. Furthermore, MSCs derived from foetal adnexa and fluid preserve some of the characteristics of the primitive embryonic layers from which they originate and seem to present immune-modulatory properties that make them a good candidate for allo- and xenotransplantation. The aim of the present review is to offer an update on the state of the art on canine MSCs derived from foetal adnexa and fluid focusing on the findings in their clinical setting. |
| first_indexed | 2024-03-10T09:04:03Z |
| format | Article |
| id | doaj.art-204f7363f2e74a5c89e10bf33aad13a9 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T09:04:03Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-204f7363f2e74a5c89e10bf33aad13a92023-11-22T06:29:25ZengMDPI AGAnimals2076-26152021-07-01118225410.3390/ani11082254Current Status on Canine Foetal Fluid and Adnexa Derived Mesenchymal Stem CellsEleonora Iacono0Romina Marcoccia1Barbara Merlo2Department of Veterinary Medical Sciences, University of Bologna, 40126 Bologna, ItalyDepartment of Veterinary Medical Sciences, University of Bologna, 40126 Bologna, ItalyDepartment of Veterinary Medical Sciences, University of Bologna, 40126 Bologna, ItalyEffective standards of care treatment guidelines have been developed for many canine diseases. However, a subpopulation of patients is partially or completely refractory to these protocols, so their owners seek novel therapies such as treatments with MSCs. Although in dogs, as with human medicine, the most studied MSCs sources have been bone marrow and adipose tissue, in recent years, many researchers have drawn attention towards alternative sources, such as foetal adnexa and fluid, since they possess many advantages over bone marrow and adipose tissue. Foetal adnexa and fluid could be considered as discarded material; therefore, sampling is non-invasive, inexpensive and free from ethical considerations. Furthermore, MSCs derived from foetal adnexa and fluid preserve some of the characteristics of the primitive embryonic layers from which they originate and seem to present immune-modulatory properties that make them a good candidate for allo- and xenotransplantation. The aim of the present review is to offer an update on the state of the art on canine MSCs derived from foetal adnexa and fluid focusing on the findings in their clinical setting.https://www.mdpi.com/2076-2615/11/8/2254dogfoetal adnexamesenchymal stem cellstherapy |
| spellingShingle | Eleonora Iacono Romina Marcoccia Barbara Merlo Current Status on Canine Foetal Fluid and Adnexa Derived Mesenchymal Stem Cells Animals dog foetal adnexa mesenchymal stem cells therapy |
| title | Current Status on Canine Foetal Fluid and Adnexa Derived Mesenchymal Stem Cells |
| title_full | Current Status on Canine Foetal Fluid and Adnexa Derived Mesenchymal Stem Cells |
| title_fullStr | Current Status on Canine Foetal Fluid and Adnexa Derived Mesenchymal Stem Cells |
| title_full_unstemmed | Current Status on Canine Foetal Fluid and Adnexa Derived Mesenchymal Stem Cells |
| title_short | Current Status on Canine Foetal Fluid and Adnexa Derived Mesenchymal Stem Cells |
| title_sort | current status on canine foetal fluid and adnexa derived mesenchymal stem cells |
| topic | dog foetal adnexa mesenchymal stem cells therapy |
| url | https://www.mdpi.com/2076-2615/11/8/2254 |
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