Shining dead bone—cause for cautious interpretation of [18F]NaF PET scans
Background and purpose — [18F]Fluoride ([18F]NaF) PET scan is frequently used for estimation of bone healing rate and extent in cases of bone allografting and fracture healing. Some authors claim that [18F]NaF uptake is a measure of osteoblastic activity, calcium metabolism, or bone turnover. Based...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2018-01-01
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| Series: | Acta Orthopaedica |
| Online Access: | http://dx.doi.org/10.1080/17453674.2017.1372097 |
| _version_ | 1798019196074852352 |
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| author | Magnus Bernhardsson Olof Sandberg Marcus Ressner Jacek Koziorowski Jonas Malmquist Per Aspenberg |
| author_facet | Magnus Bernhardsson Olof Sandberg Marcus Ressner Jacek Koziorowski Jonas Malmquist Per Aspenberg |
| author_sort | Magnus Bernhardsson |
| collection | DOAJ |
| description | Background and purpose — [18F]Fluoride ([18F]NaF) PET scan is frequently used for estimation of bone healing rate and extent in cases of bone allografting and fracture healing. Some authors claim that [18F]NaF uptake is a measure of osteoblastic activity, calcium metabolism, or bone turnover. Based on the known affinity of fluoride to hydroxyapatite, we challenged this view. Methods — 10 male rats received crushed, frozen allogeneic cortical bone fragments in a pouch in the abdominal wall on the right side, and hydroxyapatite granules on left side. [18F]NaF was injected intravenously after 7 days. 60 minutes later, the rats were killed and [18F]NaF uptake was visualized in a PET/CT scanner. Specimens were retrieved for micro CT and histology. Results — MicroCT and histology showed no signs of new bone at the implant sites. Still, the implants showed a very high [18F]NaF uptake, on a par with the most actively growing and remodeling sites around the knee joint. Interpretation — [18F]NaF binds with high affinity to dead bone and calcium phosphate materials. Hence, an [18F]NaF PET/CT scan does not allow for sound conclusions about new bone ingrowth into bone allograft, healing activity in long bone shaft fractures with necrotic fragments, or remodeling around calcium phosphate coated prostheses |
| first_indexed | 2024-04-11T16:36:38Z |
| format | Article |
| id | doaj.art-2050821efc8e4f37862d5df579f13f53 |
| institution | Directory Open Access Journal |
| issn | 1745-3674 1745-3682 |
| language | English |
| last_indexed | 2024-04-11T16:36:38Z |
| publishDate | 2018-01-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Orthopaedica |
| spelling | doaj.art-2050821efc8e4f37862d5df579f13f532022-12-22T04:13:47ZengMedical Journals SwedenActa Orthopaedica1745-36741745-36822018-01-0189112412710.1080/17453674.2017.13720971372097Shining dead bone—cause for cautious interpretation of [18F]NaF PET scansMagnus Bernhardsson0Olof Sandberg1Marcus Ressner2Jacek Koziorowski3Jonas Malmquist4Per Aspenberg5Linköping UniversityLinköping UniversityLinköping UniversityLinköping UniversityLinköping UniversityLinköping UniversityBackground and purpose — [18F]Fluoride ([18F]NaF) PET scan is frequently used for estimation of bone healing rate and extent in cases of bone allografting and fracture healing. Some authors claim that [18F]NaF uptake is a measure of osteoblastic activity, calcium metabolism, or bone turnover. Based on the known affinity of fluoride to hydroxyapatite, we challenged this view. Methods — 10 male rats received crushed, frozen allogeneic cortical bone fragments in a pouch in the abdominal wall on the right side, and hydroxyapatite granules on left side. [18F]NaF was injected intravenously after 7 days. 60 minutes later, the rats were killed and [18F]NaF uptake was visualized in a PET/CT scanner. Specimens were retrieved for micro CT and histology. Results — MicroCT and histology showed no signs of new bone at the implant sites. Still, the implants showed a very high [18F]NaF uptake, on a par with the most actively growing and remodeling sites around the knee joint. Interpretation — [18F]NaF binds with high affinity to dead bone and calcium phosphate materials. Hence, an [18F]NaF PET/CT scan does not allow for sound conclusions about new bone ingrowth into bone allograft, healing activity in long bone shaft fractures with necrotic fragments, or remodeling around calcium phosphate coated prostheseshttp://dx.doi.org/10.1080/17453674.2017.1372097 |
| spellingShingle | Magnus Bernhardsson Olof Sandberg Marcus Ressner Jacek Koziorowski Jonas Malmquist Per Aspenberg Shining dead bone—cause for cautious interpretation of [18F]NaF PET scans Acta Orthopaedica |
| title | Shining dead bone—cause for cautious interpretation of [18F]NaF PET scans |
| title_full | Shining dead bone—cause for cautious interpretation of [18F]NaF PET scans |
| title_fullStr | Shining dead bone—cause for cautious interpretation of [18F]NaF PET scans |
| title_full_unstemmed | Shining dead bone—cause for cautious interpretation of [18F]NaF PET scans |
| title_short | Shining dead bone—cause for cautious interpretation of [18F]NaF PET scans |
| title_sort | shining dead bone cause for cautious interpretation of 18f naf pet scans |
| url | http://dx.doi.org/10.1080/17453674.2017.1372097 |
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