The Prevalence and Incidence of Latent Tuberculosis Infection and Its Associated Factors among Village Doctors in China.
<h4>Background</h4>China is a high tuberculosis (TB) burden country. More than half of acute TB cases first seek medical care in village doctors' clinics or community health centers. Despite being responsible for patient referral and management, village doctors are not systematicall...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0124097 |
| _version_ | 1819029101703331840 |
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| author | Guangxue He Yuan Li Fei Zhao Lixia Wang Shiming Cheng Hui Guo John D Klena Haiying Fan Fangfang Gao Fei Gao Guoxin Han Liping Ren Yudan Song Yongchao Xiong Mengjie Geng Yueyun Hou Guoming He Jianbo Li Shufang Guo Jun Yang Daiqin Yan Yali Wang Haiyan Gao Jing An Xiaoyan Duan Chunru Wu Fengming Duan Dongmei Hu Kai Lu Yanlin Zhao Carol Y Rao Yu Wang |
| author_facet | Guangxue He Yuan Li Fei Zhao Lixia Wang Shiming Cheng Hui Guo John D Klena Haiying Fan Fangfang Gao Fei Gao Guoxin Han Liping Ren Yudan Song Yongchao Xiong Mengjie Geng Yueyun Hou Guoming He Jianbo Li Shufang Guo Jun Yang Daiqin Yan Yali Wang Haiyan Gao Jing An Xiaoyan Duan Chunru Wu Fengming Duan Dongmei Hu Kai Lu Yanlin Zhao Carol Y Rao Yu Wang |
| author_sort | Guangxue He |
| collection | DOAJ |
| description | <h4>Background</h4>China is a high tuberculosis (TB) burden country. More than half of acute TB cases first seek medical care in village doctors' clinics or community health centers. Despite being responsible for patient referral and management, village doctors are not systematically evaluated for TB infection or disease. We assessed prevalence and incidence of latent TB infection (LTBI) among village doctors in China.<h4>Methods and findings</h4>A longitudinal study was conducted in Inner Mongolia Autonomous Region. We administered a questionnaire on demographics and risk factors for TB exposure and disease; Tuberculin skin testing (TST) and QuantiFERON-TB Gold in-tube assay (QFT-GIT) was conducted at baseline and repeated 12 months later. We used a logistic regression model to calculate adjusted odds ratios (ORs) for risk factors for TST and QFT-GIT prevalence and incidence. At the time of follow up, 19.5% of the 880 participating village doctors had a positive TST and 46.0% had a positive QFT-GIT result. Factors associated with TST prevalence included having a BCG scar (OR = 1.45, 95%CI 1.03-2.04) and smoking (OR = 1.69, 95%CI 1.17-2.44). Risk factors associated with QFT-GIT prevalence included being male (OR = 2.17, 95%CI 1.63-2.89), below college education (OR=1.42, 95%CI 1.01-1.97), and working for ≥25 years as a village doctor (OR = 1.64, 95%CI 1.12-2.39). The annual incidence of LTBI was 11.4% by TST and 19.1% by QFT-GIT. QFT-GIT conversion was associated with spending 15 minutes or more per patient on average (OR = 2.62, 95%CI 1.39-4.97) and having BCG scar (OR = 0.53, 95%CI 0.28-1.00).<h4>Conclusions</h4>Prevalence and incidence of LTBI among Chinese village doctors is high. TB infection control measures should be strengthened among village doctors and at village healthcare settings. |
| first_indexed | 2024-12-21T06:08:55Z |
| format | Article |
| id | doaj.art-205787d2b4a94eff938f117c27d6b3d6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T06:08:55Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-205787d2b4a94eff938f117c27d6b3d62022-12-21T19:13:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01105e012409710.1371/journal.pone.0124097The Prevalence and Incidence of Latent Tuberculosis Infection and Its Associated Factors among Village Doctors in China.Guangxue HeYuan LiFei ZhaoLixia WangShiming ChengHui GuoJohn D KlenaHaiying FanFangfang GaoFei GaoGuoxin HanLiping RenYudan SongYongchao XiongMengjie GengYueyun HouGuoming HeJianbo LiShufang GuoJun YangDaiqin YanYali WangHaiyan GaoJing AnXiaoyan DuanChunru WuFengming DuanDongmei HuKai LuYanlin ZhaoCarol Y RaoYu Wang<h4>Background</h4>China is a high tuberculosis (TB) burden country. More than half of acute TB cases first seek medical care in village doctors' clinics or community health centers. Despite being responsible for patient referral and management, village doctors are not systematically evaluated for TB infection or disease. We assessed prevalence and incidence of latent TB infection (LTBI) among village doctors in China.<h4>Methods and findings</h4>A longitudinal study was conducted in Inner Mongolia Autonomous Region. We administered a questionnaire on demographics and risk factors for TB exposure and disease; Tuberculin skin testing (TST) and QuantiFERON-TB Gold in-tube assay (QFT-GIT) was conducted at baseline and repeated 12 months later. We used a logistic regression model to calculate adjusted odds ratios (ORs) for risk factors for TST and QFT-GIT prevalence and incidence. At the time of follow up, 19.5% of the 880 participating village doctors had a positive TST and 46.0% had a positive QFT-GIT result. Factors associated with TST prevalence included having a BCG scar (OR = 1.45, 95%CI 1.03-2.04) and smoking (OR = 1.69, 95%CI 1.17-2.44). Risk factors associated with QFT-GIT prevalence included being male (OR = 2.17, 95%CI 1.63-2.89), below college education (OR=1.42, 95%CI 1.01-1.97), and working for ≥25 years as a village doctor (OR = 1.64, 95%CI 1.12-2.39). The annual incidence of LTBI was 11.4% by TST and 19.1% by QFT-GIT. QFT-GIT conversion was associated with spending 15 minutes or more per patient on average (OR = 2.62, 95%CI 1.39-4.97) and having BCG scar (OR = 0.53, 95%CI 0.28-1.00).<h4>Conclusions</h4>Prevalence and incidence of LTBI among Chinese village doctors is high. TB infection control measures should be strengthened among village doctors and at village healthcare settings.https://doi.org/10.1371/journal.pone.0124097 |
| spellingShingle | Guangxue He Yuan Li Fei Zhao Lixia Wang Shiming Cheng Hui Guo John D Klena Haiying Fan Fangfang Gao Fei Gao Guoxin Han Liping Ren Yudan Song Yongchao Xiong Mengjie Geng Yueyun Hou Guoming He Jianbo Li Shufang Guo Jun Yang Daiqin Yan Yali Wang Haiyan Gao Jing An Xiaoyan Duan Chunru Wu Fengming Duan Dongmei Hu Kai Lu Yanlin Zhao Carol Y Rao Yu Wang The Prevalence and Incidence of Latent Tuberculosis Infection and Its Associated Factors among Village Doctors in China. PLoS ONE |
| title | The Prevalence and Incidence of Latent Tuberculosis Infection and Its Associated Factors among Village Doctors in China. |
| title_full | The Prevalence and Incidence of Latent Tuberculosis Infection and Its Associated Factors among Village Doctors in China. |
| title_fullStr | The Prevalence and Incidence of Latent Tuberculosis Infection and Its Associated Factors among Village Doctors in China. |
| title_full_unstemmed | The Prevalence and Incidence of Latent Tuberculosis Infection and Its Associated Factors among Village Doctors in China. |
| title_short | The Prevalence and Incidence of Latent Tuberculosis Infection and Its Associated Factors among Village Doctors in China. |
| title_sort | prevalence and incidence of latent tuberculosis infection and its associated factors among village doctors in china |
| url | https://doi.org/10.1371/journal.pone.0124097 |
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