PM<sub>2.5</sub>-Induced Cardiac Structural Modifications and Declined Pro-Survival Signalling Pathways Are Responsible for the Inefficiency of GSK-3β Inhibitor in Attenuating Myocardial Ischemia-Reperfusion Injury in Rats

PM<sub>2.5</sub>-Induced Cardiac Structural Modifications and Declined Pro-Survival Signalling Pathways Are Responsible for the Inefficiency of GSK-3β Inhibitor in Attenuating Myocardial Ischemia-Reperfusion Injury in Rats

Circulatory GSK3β is recognized as a biomarker and therapeutic target for diseases, including myocardial diseases. However, its potential as a target for myocardial ischemia-reperfusion injury (IR) in the presence of PM<sub>2.5</sub> exposure is unclear. Wistar rats underwent IR followin...

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Bibliographic Details
Main Authors: Bhavana Sivakumar, Nemat Ali, Sheikh F. Ahmad, Ahmed Nadeem, Mohammad Waseem, Gino A. Kurian
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
PM<sub>2.5</sub>
cardiovascular diseases
diesel particulate matter
GSK 3β
SB216763
ischemia-reperfusion injury
Online Access:https://www.mdpi.com/2073-4409/12/16/2064

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