Critically appraised topic on Rapid Eye Movement Behavior Disorder: From protein misfolding processes to clinical pathophysiology and conversion to neurodegenerative disorders
Background: REM Behavior Disorder (RBD) is considered one of most powerful prodromal condition in different neurodegenerative disorders, mainly alpha-synucleinopathies. A large amount of research recently explored this relationship. Objective and Design: The present critically appraised review...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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AIMS Press
2023-06-01
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| Series: | AIMS Molecular Science |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/molsci.2023010?viewType=HTML |
| _version_ | 1827820694800433152 |
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| author | Andrea Bernardini Gaia Pellitteri Giovanni Ermanis Gian Luigi Gigli Mariarosaria Valente Francesco Janes |
| author_facet | Andrea Bernardini Gaia Pellitteri Giovanni Ermanis Gian Luigi Gigli Mariarosaria Valente Francesco Janes |
| author_sort | Andrea Bernardini |
| collection | DOAJ |
| description | Background:
REM Behavior Disorder (RBD) is considered one of most powerful prodromal condition in different neurodegenerative disorders, mainly alpha-synucleinopathies. A large amount of research recently explored this relationship.
Objective and Design:
The present critically appraised review undertakes this topic, from the perspective of the pathogenetic interplay between clinical manifestations in RBD patients and the misfolding processes that characterize neurodegeneration. In particular, evidence in favor and against the role of RBD as a biomarker of neurodegeneration is discussed.
Results and Conclusion:
The selected papers were functional to structure the review into three main sections: 1) Protein misfolding in neurodegenerative disorders with focus on alpha-synuclein; 2) Clinical features, diagnosis, and pathophysiology of RBD; 3) RBD as a clinical biomarker of protein misfolding. Data herein highlights the current knowledge and the areas of uncertainties in the relationship between RBD and neurodegenerative disorders; we went through preclinical, prodromal and clinical stages of neurodegenerative processes as a useful reference for clinicians involved in brain pathological aging and future research in this field. |
| first_indexed | 2024-03-12T01:30:58Z |
| format | Article |
| id | doaj.art-205a2812dfc74c7d95b2c0a78fe33b27 |
| institution | Directory Open Access Journal |
| issn | 2372-0301 |
| language | English |
| last_indexed | 2024-03-12T01:30:58Z |
| publishDate | 2023-06-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Molecular Science |
| spelling | doaj.art-205a2812dfc74c7d95b2c0a78fe33b272023-09-12T01:28:16ZengAIMS PressAIMS Molecular Science2372-03012023-06-0110212715210.3934/molsci.2023010Critically appraised topic on Rapid Eye Movement Behavior Disorder: From protein misfolding processes to clinical pathophysiology and conversion to neurodegenerative disordersAndrea Bernardini 0Gaia Pellitteri1Giovanni Ermanis2Gian Luigi Gigli3Mariarosaria Valente 4 Francesco Janes 51. Department of Head and Neck, Udine Academic Hospital, 15 Santa Maria della Misericordia Square, Udine, UD 33100, IT 2. Department of Medicine, University of Udine, 44th Colugna St., Udine, UD 33100, IT1. Department of Head and Neck, Udine Academic Hospital, 15 Santa Maria della Misericordia Square, Udine, UD 33100, IT2. Department of Medicine, University of Udine, 44th Colugna St., Udine, UD 33100, IT2. Department of Medicine, University of Udine, 44th Colugna St., Udine, UD 33100, IT1. Department of Head and Neck, Udine Academic Hospital, 15 Santa Maria della Misericordia Square, Udine, UD 33100, IT 2. Department of Medicine, University of Udine, 44th Colugna St., Udine, UD 33100, IT1. Department of Head and Neck, Udine Academic Hospital, 15 Santa Maria della Misericordia Square, Udine, UD 33100, IT 2. Department of Medicine, University of Udine, 44th Colugna St., Udine, UD 33100, ITBackground: REM Behavior Disorder (RBD) is considered one of most powerful prodromal condition in different neurodegenerative disorders, mainly alpha-synucleinopathies. A large amount of research recently explored this relationship. Objective and Design: The present critically appraised review undertakes this topic, from the perspective of the pathogenetic interplay between clinical manifestations in RBD patients and the misfolding processes that characterize neurodegeneration. In particular, evidence in favor and against the role of RBD as a biomarker of neurodegeneration is discussed. Results and Conclusion: The selected papers were functional to structure the review into three main sections: 1) Protein misfolding in neurodegenerative disorders with focus on alpha-synuclein; 2) Clinical features, diagnosis, and pathophysiology of RBD; 3) RBD as a clinical biomarker of protein misfolding. Data herein highlights the current knowledge and the areas of uncertainties in the relationship between RBD and neurodegenerative disorders; we went through preclinical, prodromal and clinical stages of neurodegenerative processes as a useful reference for clinicians involved in brain pathological aging and future research in this field.https://www.aimspress.com/article/doi/10.3934/molsci.2023010?viewType=HTMLrem behavior disorderrem parasomniasrem without atonia (rwa)alpha-synucleinparkinsonismneurodegenerative disordersprodromal parkinson's diseaseprotein misfolding |
| spellingShingle | Andrea Bernardini Gaia Pellitteri Giovanni Ermanis Gian Luigi Gigli Mariarosaria Valente Francesco Janes Critically appraised topic on Rapid Eye Movement Behavior Disorder: From protein misfolding processes to clinical pathophysiology and conversion to neurodegenerative disorders AIMS Molecular Science rem behavior disorder rem parasomnias rem without atonia (rwa) alpha-synuclein parkinsonism neurodegenerative disorders prodromal parkinson's disease protein misfolding |
| title | Critically appraised topic on Rapid Eye Movement Behavior Disorder: From protein misfolding processes to clinical pathophysiology and conversion to neurodegenerative disorders |
| title_full | Critically appraised topic on Rapid Eye Movement Behavior Disorder: From protein misfolding processes to clinical pathophysiology and conversion to neurodegenerative disorders |
| title_fullStr | Critically appraised topic on Rapid Eye Movement Behavior Disorder: From protein misfolding processes to clinical pathophysiology and conversion to neurodegenerative disorders |
| title_full_unstemmed | Critically appraised topic on Rapid Eye Movement Behavior Disorder: From protein misfolding processes to clinical pathophysiology and conversion to neurodegenerative disorders |
| title_short | Critically appraised topic on Rapid Eye Movement Behavior Disorder: From protein misfolding processes to clinical pathophysiology and conversion to neurodegenerative disorders |
| title_sort | critically appraised topic on rapid eye movement behavior disorder from protein misfolding processes to clinical pathophysiology and conversion to neurodegenerative disorders |
| topic | rem behavior disorder rem parasomnias rem without atonia (rwa) alpha-synuclein parkinsonism neurodegenerative disorders prodromal parkinson's disease protein misfolding |
| url | https://www.aimspress.com/article/doi/10.3934/molsci.2023010?viewType=HTML |
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