The Role of Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration: Phagocytosis and Autophagy
Age-related macular degeneration (AMD) causes vision loss in the elderly population. Dry AMD leads to the formation of Drusen, while wet AMD is characterized by cell proliferation and choroidal angiogenesis. The retinal pigment epithelium (RPE) plays a key role in AMD pathogenesis. In particular, he...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/6/901 |
| _version_ | 1797595795024773120 |
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| author | Zhibo Si Yajuan Zheng Jing Zhao |
| author_facet | Zhibo Si Yajuan Zheng Jing Zhao |
| author_sort | Zhibo Si |
| collection | DOAJ |
| description | Age-related macular degeneration (AMD) causes vision loss in the elderly population. Dry AMD leads to the formation of Drusen, while wet AMD is characterized by cell proliferation and choroidal angiogenesis. The retinal pigment epithelium (RPE) plays a key role in AMD pathogenesis. In particular, helioreceptor renewal depends on outer segment phagocytosis of RPE cells, while RPE autophagy can protect cells from oxidative stress damage. However, when the oxidative stress burden is too high and homeostasis is disturbed, the phagocytosis and autophagy functions of RPE become damaged, leading to AMD development and progression. Hence, characterizing the roles of RPE cell phagocytosis and autophagy in the pathogenesis of AMD can inform the development of potential therapeutic targets to prevent irreversible RPE and photoreceptor cell death, thus protecting against AMD. |
| first_indexed | 2024-03-11T02:42:30Z |
| format | Article |
| id | doaj.art-205a5bcca30a43a0884854680c706860 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T02:42:30Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-205a5bcca30a43a0884854680c7068602023-11-18T09:30:25ZengMDPI AGBiomolecules2218-273X2023-05-0113690110.3390/biom13060901The Role of Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration: Phagocytosis and AutophagyZhibo Si0Yajuan Zheng1Jing Zhao2Department of Ophthalmology, The Second Hospital of Jilin University, Changchun 130000, ChinaDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun 130000, ChinaDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun 130000, ChinaAge-related macular degeneration (AMD) causes vision loss in the elderly population. Dry AMD leads to the formation of Drusen, while wet AMD is characterized by cell proliferation and choroidal angiogenesis. The retinal pigment epithelium (RPE) plays a key role in AMD pathogenesis. In particular, helioreceptor renewal depends on outer segment phagocytosis of RPE cells, while RPE autophagy can protect cells from oxidative stress damage. However, when the oxidative stress burden is too high and homeostasis is disturbed, the phagocytosis and autophagy functions of RPE become damaged, leading to AMD development and progression. Hence, characterizing the roles of RPE cell phagocytosis and autophagy in the pathogenesis of AMD can inform the development of potential therapeutic targets to prevent irreversible RPE and photoreceptor cell death, thus protecting against AMD.https://www.mdpi.com/2218-273X/13/6/901age-related macular degenerationautophagyoxidative stressphagocytosisretinal pigment epithelial cell |
| spellingShingle | Zhibo Si Yajuan Zheng Jing Zhao The Role of Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration: Phagocytosis and Autophagy Biomolecules age-related macular degeneration autophagy oxidative stress phagocytosis retinal pigment epithelial cell |
| title | The Role of Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration: Phagocytosis and Autophagy |
| title_full | The Role of Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration: Phagocytosis and Autophagy |
| title_fullStr | The Role of Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration: Phagocytosis and Autophagy |
| title_full_unstemmed | The Role of Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration: Phagocytosis and Autophagy |
| title_short | The Role of Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration: Phagocytosis and Autophagy |
| title_sort | role of retinal pigment epithelial cells in age related macular degeneration phagocytosis and autophagy |
| topic | age-related macular degeneration autophagy oxidative stress phagocytosis retinal pigment epithelial cell |
| url | https://www.mdpi.com/2218-273X/13/6/901 |
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