Dual Role for Astroglial Copper-Assisted Polyamine Metabolism during Intense Network Activity

Dual Role for Astroglial Copper-Assisted Polyamine Metabolism during Intense Network Activity

Astrocytes serve essential roles in human brain function and diseases. Growing evidence indicates that astrocytes are central players of the feedback modulation of excitatory Glu signalling during epileptiform activity via Glu-GABA exchange. The underlying mechanism results in the increase of tonic...

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Bibliographic Details
Main Authors:	Zsolt Szabó, Márton Péter, László Héja, Julianna Kardos
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Biomolecules
Subjects:	astroglial tonic inhibitory feedback astroglial GABA transporter copper transporter CTR1 putrescine catabolism copper amino oxidase Cx43 gap junction channel
Online Access:	https://www.mdpi.com/2218-273X/11/4/604

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