Type 2 diabetes and inflammatory bowel disease: a bidirectional two-sample Mendelian randomization study
Abstract To investigate the association between T2DM and IBD by bidirectional two-sample Mendelian randomization (MR) to clarify the casual relationship. Independent genetic variants for T2DM and IBD were selected as instruments from published genome-wide association studies (GWAS), mainly in Europe...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-55869-x |
| _version_ | 1827327559225835520 |
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| author | Guangyi Xu Yanhong Xu Taohua Zheng Ting Liu |
| author_facet | Guangyi Xu Yanhong Xu Taohua Zheng Ting Liu |
| author_sort | Guangyi Xu |
| collection | DOAJ |
| description | Abstract To investigate the association between T2DM and IBD by bidirectional two-sample Mendelian randomization (MR) to clarify the casual relationship. Independent genetic variants for T2DM and IBD were selected as instruments from published genome-wide association studies (GWAS), mainly in European ancestry. Instrumental variables (IVs) associated with T2DM and IBD were extracted separately from the largest GWAS meta-analysis. MR analyses included inverse variance weighting, weighted median estimator, MR Egger regression, and sensitivity analyses with Steiger filtering and MR PRESSO. In the data samples for Ulcerative colitis (UC) (6968 cases, 20,464 controls) and Crohn's disease (CD) (5956 cases, 14,927 controls), there was a negative causal relationship between T2DM and UC [IVW, OR/95%CI: 0.882/(0.826,0.942), p < 0.001]. However, the causal relationships between T2DM and CD, UC and T2DM, CD and T2DM were not significant, and the p value measured by the IVW method was ≥ 0.05. All SNPs showed no significant horizontal pleiotropy (p > 0.05). The results of the bidirectional MR Study suggest that T2DM has a negative causal effect on UC, which provides implications for clinical treatment decisions in IBD patients with T2DM. The findings do not support a causal relationship between T2DM and CD, UC and T2DM, or CD and T2DM, and the impact of IBD on T2DM needs further investigation. |
| first_indexed | 2024-03-07T15:03:03Z |
| format | Article |
| id | doaj.art-2062b68eaa9e49199a0523bfb7c4fe14 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:03:03Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2062b68eaa9e49199a0523bfb7c4fe142024-03-05T19:00:29ZengNature PortfolioScientific Reports2045-23222024-03-011411910.1038/s41598-024-55869-xType 2 diabetes and inflammatory bowel disease: a bidirectional two-sample Mendelian randomization studyGuangyi Xu0Yanhong Xu1Taohua Zheng2Ting Liu3School of Nursing, Qingdao UniversityDepartment of Gastroenterology, The Affiliated Hospital of Qingdao UniversityDepartment of Gastroenterology, The Affiliated Hospital of Qingdao UniversitySchool of Nursing, Qingdao UniversityAbstract To investigate the association between T2DM and IBD by bidirectional two-sample Mendelian randomization (MR) to clarify the casual relationship. Independent genetic variants for T2DM and IBD were selected as instruments from published genome-wide association studies (GWAS), mainly in European ancestry. Instrumental variables (IVs) associated with T2DM and IBD were extracted separately from the largest GWAS meta-analysis. MR analyses included inverse variance weighting, weighted median estimator, MR Egger regression, and sensitivity analyses with Steiger filtering and MR PRESSO. In the data samples for Ulcerative colitis (UC) (6968 cases, 20,464 controls) and Crohn's disease (CD) (5956 cases, 14,927 controls), there was a negative causal relationship between T2DM and UC [IVW, OR/95%CI: 0.882/(0.826,0.942), p < 0.001]. However, the causal relationships between T2DM and CD, UC and T2DM, CD and T2DM were not significant, and the p value measured by the IVW method was ≥ 0.05. All SNPs showed no significant horizontal pleiotropy (p > 0.05). The results of the bidirectional MR Study suggest that T2DM has a negative causal effect on UC, which provides implications for clinical treatment decisions in IBD patients with T2DM. The findings do not support a causal relationship between T2DM and CD, UC and T2DM, or CD and T2DM, and the impact of IBD on T2DM needs further investigation.https://doi.org/10.1038/s41598-024-55869-xType 2 diabetes mellitusInflammatory bowel diseaseMendelian randomization |
| spellingShingle | Guangyi Xu Yanhong Xu Taohua Zheng Ting Liu Type 2 diabetes and inflammatory bowel disease: a bidirectional two-sample Mendelian randomization study Scientific Reports Type 2 diabetes mellitus Inflammatory bowel disease Mendelian randomization |
| title | Type 2 diabetes and inflammatory bowel disease: a bidirectional two-sample Mendelian randomization study |
| title_full | Type 2 diabetes and inflammatory bowel disease: a bidirectional two-sample Mendelian randomization study |
| title_fullStr | Type 2 diabetes and inflammatory bowel disease: a bidirectional two-sample Mendelian randomization study |
| title_full_unstemmed | Type 2 diabetes and inflammatory bowel disease: a bidirectional two-sample Mendelian randomization study |
| title_short | Type 2 diabetes and inflammatory bowel disease: a bidirectional two-sample Mendelian randomization study |
| title_sort | type 2 diabetes and inflammatory bowel disease a bidirectional two sample mendelian randomization study |
| topic | Type 2 diabetes mellitus Inflammatory bowel disease Mendelian randomization |
| url | https://doi.org/10.1038/s41598-024-55869-x |
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