The Economic, Medical and Psychosocial Consequences of Whole Genome Sequencing for the Genetic Diagnosis of Patients With Intellectual Disability: The DEFIDIAG Study Protocol
Introduction: Like other countries, France has invested in a national medical genomics program. Among the four pilot research studies, the DEFIDIAG project focuses on the use of whole genome sequencing (WGS) for patients with intellectual disability (ID), a neurodevelopmental condition affecting 1–3...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.852472/full |
| _version_ | 1811284709462769664 |
|---|---|
| author | Catherine Lejeune Catherine Lejeune Charley Robert-Viard Charley Robert-Viard Nicolas Meunier-Beillard Nicolas Meunier-Beillard Myriam Alice Borel Léna Gourvès Stéphanie Staraci Anne-Laure Soilly Francis Guillemin Valerie Seror Hamza Achit Marion Bouctot Marie-Laure Asensio Anne-Sophie Briffaut Christelle Delmas Ange-Line Bruel Alexia Benoit Alban Simon Bénédicte Gerard Hamza Hadj Abdallah Hamza Hadj Abdallah Stanislas Lyonnet Stanislas Lyonnet Laurence Faivre Christel Thauvin-Robinet Sylvie Odent Delphine Heron Damien Sanlaville Thierry Frebourg Thierry Frebourg Jean Muller Jean Muller Jean Muller Yannis Duffourd Anne Boland Jean-François Deleuze Hélène Espérou Christine Binquet Hélène Dollfus |
| author_facet | Catherine Lejeune Catherine Lejeune Charley Robert-Viard Charley Robert-Viard Nicolas Meunier-Beillard Nicolas Meunier-Beillard Myriam Alice Borel Léna Gourvès Stéphanie Staraci Anne-Laure Soilly Francis Guillemin Valerie Seror Hamza Achit Marion Bouctot Marie-Laure Asensio Anne-Sophie Briffaut Christelle Delmas Ange-Line Bruel Alexia Benoit Alban Simon Bénédicte Gerard Hamza Hadj Abdallah Hamza Hadj Abdallah Stanislas Lyonnet Stanislas Lyonnet Laurence Faivre Christel Thauvin-Robinet Sylvie Odent Delphine Heron Damien Sanlaville Thierry Frebourg Thierry Frebourg Jean Muller Jean Muller Jean Muller Yannis Duffourd Anne Boland Jean-François Deleuze Hélène Espérou Christine Binquet Hélène Dollfus |
| author_sort | Catherine Lejeune |
| collection | DOAJ |
| description | Introduction: Like other countries, France has invested in a national medical genomics program. Among the four pilot research studies, the DEFIDIAG project focuses on the use of whole genome sequencing (WGS) for patients with intellectual disability (ID), a neurodevelopmental condition affecting 1–3% of the general population but due to a plethora of genes. However, the access to genomic analyses has many potential individual and societal issues in addition to the technical challenges. In order to help decision-makers optimally introduce genomic testing in France, there is a need to identify the socio-economic obstacles and leverages associated with the implementation of WGS.Methods and Analysis: This humanities and social sciences analysis is part of the DEFIDIAG study. The main goal of DEFIDIAG is to compare the percentage of causal genetic diagnoses obtained by trio WGS (including the patient and both parents) (WGST) to the percentage obtained using the minimal reference strategy currently used in France (Fragile-X testing, chromosomal microarray analysis, and gene panel strategy including 44 ID genes) for patients with ID having their first clinical genetics consultation. Additionally, four complementary studies will be conducted. First, a cost-effectiveness analysis will be undertaken in a subsample of 196 patients consulting for the first time for a genetic evaluation; in a blinded fashion, WGST and solo (index case, only) genomic analysis (WGSS) will be compared to the reference strategy. In addition, quantitative studies will be conducted: the first will estimate the cost of the diagnostic odyssey that could potentially be avoidable with first-line WGST in all patients previously investigated in the DEFIDIAG study; the second will estimate changes in follow-up of the patients in the year after the return of the WGST analysis compared to the period before inclusion. Finally, through semi-directive interviews, we will explore the expectations of 60 parents regarding genomic analyses.Discussion: Humanities and social sciences studies can be used to demonstrate the efficiency of WGS and assess the value that families associate with sequencing. These studies are thus expected to clarify trade-offs and to help optimize the implementation of genomic sequencing in France.Ethics Statement: The protocol was approved by the Ethics Committee Sud Méditerranée I (June 2019)—identification number: 2018-A00680-55 and the French data privacy commission (CNIL, authorization 919361).Clinical Trial Registration: (ClinicalTrials.gov), identifier (NCT04154891). |
| first_indexed | 2024-04-13T02:33:41Z |
| format | Article |
| id | doaj.art-20632c85104a48d79a40c08ac9c4621f |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-13T02:33:41Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-20632c85104a48d79a40c08ac9c4621f2022-12-22T03:06:28ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-04-011310.3389/fgene.2022.852472852472The Economic, Medical and Psychosocial Consequences of Whole Genome Sequencing for the Genetic Diagnosis of Patients With Intellectual Disability: The DEFIDIAG Study ProtocolCatherine Lejeune0Catherine Lejeune1Charley Robert-Viard2Charley Robert-Viard3Nicolas Meunier-Beillard4Nicolas Meunier-Beillard5Myriam Alice Borel6Léna Gourvès7Stéphanie Staraci8Anne-Laure Soilly9Francis Guillemin10Valerie Seror11Hamza Achit12Marion Bouctot13Marie-Laure Asensio14Anne-Sophie Briffaut15Christelle Delmas16Ange-Line Bruel17Alexia Benoit18Alban Simon19Bénédicte Gerard20Hamza Hadj Abdallah21Hamza Hadj Abdallah22Stanislas Lyonnet23Stanislas Lyonnet24Laurence Faivre25Christel Thauvin-Robinet26Sylvie Odent27Delphine Heron28Damien Sanlaville29Thierry Frebourg30Thierry Frebourg31Jean Muller32Jean Muller33Jean Muller34Yannis Duffourd35Anne Boland36Jean-François Deleuze37Hélène Espérou38Christine Binquet39Hélène Dollfus40CHU Dijon Bourgogne, Inserm, Université de Bourgogne, CIC 1432, Module Épidémiologie Clinique, Dijon, FranceInserm, Université Bourgogne-Franche-Comté, UMR 1231, EPICAD, Dijon, FranceCHU Dijon Bourgogne, Inserm, Université de Bourgogne, CIC 1432, Module Épidémiologie Clinique, Dijon, FranceCHU Dijon Bourgogne, Délégation à la Recherche Clinique et à l’Innovation, USMR, Dijon, FranceCHU Dijon Bourgogne, Inserm, Université de Bourgogne, CIC 1432, Module Épidémiologie Clinique, Dijon, FranceCHU Dijon Bourgogne, Délégation à la Recherche Clinique et à l’Innovation, USMR, Dijon, FranceObservatoire Régional de Santé Bourgogne Franche-Comté, Dijon, FranceCHU Dijon Bourgogne, Direction de la Recherche Clinique, Dijon, FranceUnité Fonctionnelle de Génétique Médicale et Centre de Référence « Déficiences Intellectuelles de Causes Rares », APHP Sorbonne Université, Groupe Hospitalier Pitié-Salpêtrière et Hôpital Trousseau, Paris, FranceCHU Dijon Bourgogne, Délégation à la Recherche Clinique et à l’Innovation, USMR, Dijon, FranceCIC1433-Epidémiologie Clinique, Centre Hospitalier Régional et Universitaire, Inserm, Université de Lorraine, Nancy, FranceAix Marseille Univ, IRD, APHM, SSA, VITROME, IHU-Méditerranée Infection, Marseille, FranceCIC1433-Epidémiologie Clinique, Centre Hospitalier Régional et Universitaire, Inserm, Université de Lorraine, Nancy, FranceCHU Dijon Bourgogne, Inserm, Université de Bourgogne, CIC 1432, Module Épidémiologie Clinique, Dijon, FranceCHU Dijon Bourgogne, Inserm, Université de Bourgogne, CIC 1432, Module Épidémiologie Clinique, Dijon, FranceCHU Dijon Bourgogne, Inserm, Université de Bourgogne, CIC 1432, Module Épidémiologie Clinique, Dijon, FranceInserm, Pôle de Recherche Clinique, Paris, France0CHU Dijon Bourgogne, Fédération Hospitalo-Universitaire Médecine Translationnelle et Anomalies du Dévelopment (TRANSLAD), Inserm, Université Bourgogne-Franche-Comté, UMR1231, Équipe GAD, Dijon, France1Laboratoires de Diagnostic Génétique, Institut de Génétique Médicale d’Alsace (IGMA), Hôpitaux Universitaires de Strasbourg, Strasbourg, France2Inserm UMRS_1112, Institut de Génétique Médicale d’Alsace, Université de Strasbourg, France et Service de Génétique Médicale Hôpitaux Universitaires de Strasbourg, Strasbourg, France1Laboratoires de Diagnostic Génétique, Institut de Génétique Médicale d’Alsace (IGMA), Hôpitaux Universitaires de Strasbourg, Strasbourg, France3Inserm, IHU Imagine—Institut des Maladies Génétiques, Université Paris Cité, Paris, France4Fédération de Génétique et Médecine Génomique, Hôpital Necker-Enfants Malades, GHU APHP. Centre-Université Paris Cité, Paris, France3Inserm, IHU Imagine—Institut des Maladies Génétiques, Université Paris Cité, Paris, France4Fédération de Génétique et Médecine Génomique, Hôpital Necker-Enfants Malades, GHU APHP. Centre-Université Paris Cité, Paris, France0CHU Dijon Bourgogne, Fédération Hospitalo-Universitaire Médecine Translationnelle et Anomalies du Dévelopment (TRANSLAD), Inserm, Université Bourgogne-Franche-Comté, UMR1231, Équipe GAD, Dijon, France0CHU Dijon Bourgogne, Fédération Hospitalo-Universitaire Médecine Translationnelle et Anomalies du Dévelopment (TRANSLAD), Inserm, Université Bourgogne-Franche-Comté, UMR1231, Équipe GAD, Dijon, France5Service de Génétique Clinique, Centre de Référence Anomalies du Dévelopment CLAD- Ouest, CNRS, IGDR UMR6290 (Institut de Génétique et Dévelopment de Rennes), ERN ITHACA, Université de Rennes, Rennes, FranceUnité Fonctionnelle de Génétique Médicale et Centre de Référence « Déficiences Intellectuelles de Causes Rares », APHP Sorbonne Université, Groupe Hospitalier Pitié-Salpêtrière et Hôpital Trousseau, Paris, France6Hospices Civils de Lyon, GHE, Service de Génétique, Université Claude Bernard Lyon 1, Lyon, France7CHU de Rouen, Service de Génétique, Rouen, France8Inserm, UMR1245, Centre de Génomique et de Médecine Personnalisée, Université de Normandie, Rouen, France1Laboratoires de Diagnostic Génétique, Institut de Génétique Médicale d’Alsace (IGMA), Hôpitaux Universitaires de Strasbourg, Strasbourg, France2Inserm UMRS_1112, Institut de Génétique Médicale d’Alsace, Université de Strasbourg, France et Service de Génétique Médicale Hôpitaux Universitaires de Strasbourg, Strasbourg, France9Unité Fonctionnelle de Bioinformatique Médicale Appliquée au Diagnostic (UF7363), Hôpitaux Universitaires de Strasbourg, Strasbourg, France0CHU Dijon Bourgogne, Fédération Hospitalo-Universitaire Médecine Translationnelle et Anomalies du Dévelopment (TRANSLAD), Inserm, Université Bourgogne-Franche-Comté, UMR1231, Équipe GAD, Dijon, France0CEA, Centre National de Recherche en Génomique Humaine (CNRGH), Université Paris-Saclay, Evry, France0CEA, Centre National de Recherche en Génomique Humaine (CNRGH), Université Paris-Saclay, Evry, FranceInserm, Pôle de Recherche Clinique, Paris, FranceCHU Dijon Bourgogne, Inserm, Université de Bourgogne, CIC 1432, Module Épidémiologie Clinique, Dijon, France2Inserm UMRS_1112, Institut de Génétique Médicale d’Alsace, Université de Strasbourg, France et Service de Génétique Médicale Hôpitaux Universitaires de Strasbourg, Strasbourg, FranceIntroduction: Like other countries, France has invested in a national medical genomics program. Among the four pilot research studies, the DEFIDIAG project focuses on the use of whole genome sequencing (WGS) for patients with intellectual disability (ID), a neurodevelopmental condition affecting 1–3% of the general population but due to a plethora of genes. However, the access to genomic analyses has many potential individual and societal issues in addition to the technical challenges. In order to help decision-makers optimally introduce genomic testing in France, there is a need to identify the socio-economic obstacles and leverages associated with the implementation of WGS.Methods and Analysis: This humanities and social sciences analysis is part of the DEFIDIAG study. The main goal of DEFIDIAG is to compare the percentage of causal genetic diagnoses obtained by trio WGS (including the patient and both parents) (WGST) to the percentage obtained using the minimal reference strategy currently used in France (Fragile-X testing, chromosomal microarray analysis, and gene panel strategy including 44 ID genes) for patients with ID having their first clinical genetics consultation. Additionally, four complementary studies will be conducted. First, a cost-effectiveness analysis will be undertaken in a subsample of 196 patients consulting for the first time for a genetic evaluation; in a blinded fashion, WGST and solo (index case, only) genomic analysis (WGSS) will be compared to the reference strategy. In addition, quantitative studies will be conducted: the first will estimate the cost of the diagnostic odyssey that could potentially be avoidable with first-line WGST in all patients previously investigated in the DEFIDIAG study; the second will estimate changes in follow-up of the patients in the year after the return of the WGST analysis compared to the period before inclusion. Finally, through semi-directive interviews, we will explore the expectations of 60 parents regarding genomic analyses.Discussion: Humanities and social sciences studies can be used to demonstrate the efficiency of WGS and assess the value that families associate with sequencing. These studies are thus expected to clarify trade-offs and to help optimize the implementation of genomic sequencing in France.Ethics Statement: The protocol was approved by the Ethics Committee Sud Méditerranée I (June 2019)—identification number: 2018-A00680-55 and the French data privacy commission (CNIL, authorization 919361).Clinical Trial Registration: (ClinicalTrials.gov), identifier (NCT04154891).https://www.frontiersin.org/articles/10.3389/fgene.2022.852472/fullintellectual disabilitygenome sequencingcost-effectivenessqualitative studymicro-costing |
| spellingShingle | Catherine Lejeune Catherine Lejeune Charley Robert-Viard Charley Robert-Viard Nicolas Meunier-Beillard Nicolas Meunier-Beillard Myriam Alice Borel Léna Gourvès Stéphanie Staraci Anne-Laure Soilly Francis Guillemin Valerie Seror Hamza Achit Marion Bouctot Marie-Laure Asensio Anne-Sophie Briffaut Christelle Delmas Ange-Line Bruel Alexia Benoit Alban Simon Bénédicte Gerard Hamza Hadj Abdallah Hamza Hadj Abdallah Stanislas Lyonnet Stanislas Lyonnet Laurence Faivre Christel Thauvin-Robinet Sylvie Odent Delphine Heron Damien Sanlaville Thierry Frebourg Thierry Frebourg Jean Muller Jean Muller Jean Muller Yannis Duffourd Anne Boland Jean-François Deleuze Hélène Espérou Christine Binquet Hélène Dollfus The Economic, Medical and Psychosocial Consequences of Whole Genome Sequencing for the Genetic Diagnosis of Patients With Intellectual Disability: The DEFIDIAG Study Protocol Frontiers in Genetics intellectual disability genome sequencing cost-effectiveness qualitative study micro-costing |
| title | The Economic, Medical and Psychosocial Consequences of Whole Genome Sequencing for the Genetic Diagnosis of Patients With Intellectual Disability: The DEFIDIAG Study Protocol |
| title_full | The Economic, Medical and Psychosocial Consequences of Whole Genome Sequencing for the Genetic Diagnosis of Patients With Intellectual Disability: The DEFIDIAG Study Protocol |
| title_fullStr | The Economic, Medical and Psychosocial Consequences of Whole Genome Sequencing for the Genetic Diagnosis of Patients With Intellectual Disability: The DEFIDIAG Study Protocol |
| title_full_unstemmed | The Economic, Medical and Psychosocial Consequences of Whole Genome Sequencing for the Genetic Diagnosis of Patients With Intellectual Disability: The DEFIDIAG Study Protocol |
| title_short | The Economic, Medical and Psychosocial Consequences of Whole Genome Sequencing for the Genetic Diagnosis of Patients With Intellectual Disability: The DEFIDIAG Study Protocol |
| title_sort | economic medical and psychosocial consequences of whole genome sequencing for the genetic diagnosis of patients with intellectual disability the defidiag study protocol |
| topic | intellectual disability genome sequencing cost-effectiveness qualitative study micro-costing |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.852472/full |
| work_keys_str_mv | AT catherinelejeune theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT catherinelejeune theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT charleyrobertviard theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT charleyrobertviard theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT nicolasmeunierbeillard theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT nicolasmeunierbeillard theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT myriamaliceborel theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT lenagourves theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT stephaniestaraci theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT annelauresoilly theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT francisguillemin theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT valerieseror theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT hamzaachit theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT marionbouctot theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT marielaureasensio theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT annesophiebriffaut theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT christelledelmas theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT angelinebruel theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT alexiabenoit theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT albansimon theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT benedictegerard theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT hamzahadjabdallah theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT hamzahadjabdallah theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT stanislaslyonnet theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT stanislaslyonnet theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT laurencefaivre theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT christelthauvinrobinet theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT sylvieodent theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT delphineheron theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT damiensanlaville theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT thierryfrebourg theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT thierryfrebourg theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT jeanmuller theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT jeanmuller theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT jeanmuller theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT yannisduffourd theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT anneboland theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT jeanfrancoisdeleuze theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT heleneesperou theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT christinebinquet theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT helenedollfus theeconomicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT catherinelejeune economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT catherinelejeune economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT charleyrobertviard economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT charleyrobertviard economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT nicolasmeunierbeillard economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT nicolasmeunierbeillard economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT myriamaliceborel economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT lenagourves economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT stephaniestaraci economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT annelauresoilly economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT francisguillemin economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT valerieseror economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT hamzaachit economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT marionbouctot economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT marielaureasensio economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT annesophiebriffaut economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT christelledelmas economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT angelinebruel economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT alexiabenoit economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT albansimon economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT benedictegerard economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT hamzahadjabdallah economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT hamzahadjabdallah economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT stanislaslyonnet economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT stanislaslyonnet economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT laurencefaivre economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT christelthauvinrobinet economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT sylvieodent economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT delphineheron economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT damiensanlaville economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT thierryfrebourg economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT thierryfrebourg economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT jeanmuller economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT jeanmuller economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT jeanmuller economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT yannisduffourd economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT anneboland economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT jeanfrancoisdeleuze economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT heleneesperou economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT christinebinquet economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol AT helenedollfus economicmedicalandpsychosocialconsequencesofwholegenomesequencingforthegeneticdiagnosisofpatientswithintellectualdisabilitythedefidiagstudyprotocol |