Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol
Abstract Background Nigeria contributes significantly to the global burden of HIV, Hepatitis B and C infections, either singly or in combinations, despite progress in HIV care regionally and globally. Although some limited data on mono infection of HIV, Hepatitis B and C virus infections do exists,...
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| Format: | Article |
| Language: | English |
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BMC
2020-09-01
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| Series: | Reproductive Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12978-020-00995-8 |
| _version_ | 1818289064511537152 |
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| author | George Uchenna Eleje Ikechukwu Innocent Mbachu Uchenna Chukwunonso Ogwaluonye Stephen Okoroafor Kalu Chinyere Ukamaka Onubogu Sussan Ifeyinwa Nweje Chinwe Elizabeth Uzochukwu Chike Henry Nwankwo Preye Owen Fiebai Olabisi Morebise Loto Godwin Otuodichinma Akaba Hadiza Abdullahi Usman Ayyuba Rabiu Richard Obinwanne Egeonu Odion Emmanuel Igue Bukola Abimbola Adesoji Chiamaka Henrietta Jibuaku Prince Ogbonnia Aja Chiamaka Perpetua Chidozie Hadiza Sani Ibrahim Fatima Ele Aliyu Aisha Ismaila Numan Ogbonna Dennis Okoro Solace Amechi Omoruyi Ijeoma Chioma Oppah Ubong Inyang Anyang Aishat Ahmed Shirley Nneka Chukwurah Osita Samuel Umeononihu Rebecca Chinyelu Chukwuanukwu Eric Okechukwu Umeh Ekene Agatha Emeka Chukwuanugo Nkemakonam Ogbuagu Ibrahim Adamu Yakasai Oliver Chukwujekwu Ezechi Joseph Ifeanyichukwu Ikechebelu Triplex infection in pregnancy collaboration group |
| author_facet | George Uchenna Eleje Ikechukwu Innocent Mbachu Uchenna Chukwunonso Ogwaluonye Stephen Okoroafor Kalu Chinyere Ukamaka Onubogu Sussan Ifeyinwa Nweje Chinwe Elizabeth Uzochukwu Chike Henry Nwankwo Preye Owen Fiebai Olabisi Morebise Loto Godwin Otuodichinma Akaba Hadiza Abdullahi Usman Ayyuba Rabiu Richard Obinwanne Egeonu Odion Emmanuel Igue Bukola Abimbola Adesoji Chiamaka Henrietta Jibuaku Prince Ogbonnia Aja Chiamaka Perpetua Chidozie Hadiza Sani Ibrahim Fatima Ele Aliyu Aisha Ismaila Numan Ogbonna Dennis Okoro Solace Amechi Omoruyi Ijeoma Chioma Oppah Ubong Inyang Anyang Aishat Ahmed Shirley Nneka Chukwurah Osita Samuel Umeononihu Rebecca Chinyelu Chukwuanukwu Eric Okechukwu Umeh Ekene Agatha Emeka Chukwuanugo Nkemakonam Ogbuagu Ibrahim Adamu Yakasai Oliver Chukwujekwu Ezechi Joseph Ifeanyichukwu Ikechebelu Triplex infection in pregnancy collaboration group |
| author_sort | George Uchenna Eleje |
| collection | DOAJ |
| description | Abstract Background Nigeria contributes significantly to the global burden of HIV, Hepatitis B and C infections, either singly or in combinations, despite progress in HIV care regionally and globally. Although some limited data on mono infection of HIV, Hepatitis B and C virus infections do exists, that of dual and triplex infections, including seroconversion and mother-to-child transmission (MTCT) rates necessary for planning to address the scourge of infections in pregnancy are not available. Objectives To determine the seroprevalence, rate of new infections, MTCT of dual and triple infections of HIV, Hepatitis B and C viruses and associated factors, among pregnant women in Nigeria. Method A multicenter prospective cohort study will be conducted in six tertiary health facilities randomly selected from the six geopolitical zones of Nigeria. All eligible pregnant women are to be tested at enrollment after informed consent for HIV, Hepatitis B and C virus infections. While those positive for at least two of the infections in any combination will be enrolled into the study and followed up to 6 weeks post-delivery, those negative for the three infections or positive for only one of the infections at enrolment will be retested at delivery using a rapid diagnostic test. On enrolment into the study relevant information, will be obtained, and laboratory test of CD4 count, liver function test and full blood counts, and prenatal ultrasonography will also be obtained/performed. Management of mother-newborns pairs will be according to appropriate national guidelines. All exposed newborns will be tested for HIV, HBV or HCV infection at birth and 6 weeks using PCR technique. The study data will be documented on the study case record forms. Data will be managed with SPSS for windows version 23. Ethical approval was obtained from National Health Research Ethics Committee (NHREC) (NHREC/01/01/2007–23/01/2020). Conclusion Pregnant women with multiple of HIV, HBV and HCV infections are at increased risk of hepatotoxicity, maternal and perinatal morbidity and mortality. Additionally, infected pregnant women transmit the virus to their unborn baby even when asymptomatic. Children born with any of the infection have significantly poorer quality of life and lower five-year survival rate. Unfortunately, the seroconversion and MTCT rates of dual or triplex infections among pregnant women in Nigeria have not been studied making planning for prevention and subsequent elimination of the viruses difficult. The study is expected to fill this knowledge gaps. Nigeria joining the rest of the world to eliminate the triple infection among children rest on the availability of adequate and reliable data generated from appropriately designed, and powered study using representative population sample. The establishment of the three-in-one study of prevalence, rate of new infection, rate and risk factor for MTCT of dual and triple infection of HIV, Hepatitis B and C viruses among pregnant women in Nigeria is urgently needed for policy development and planning for the improvement of the quality of life of mothers and the elimination of childhood triplex infection. |
| first_indexed | 2024-12-13T02:06:20Z |
| format | Article |
| id | doaj.art-2064669db65845a2bcf4a4aa8a37bb00 |
| institution | Directory Open Access Journal |
| issn | 1742-4755 |
| language | English |
| last_indexed | 2024-12-13T02:06:20Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Health |
| spelling | doaj.art-2064669db65845a2bcf4a4aa8a37bb002022-12-22T00:03:07ZengBMCReproductive Health1742-47552020-09-011711910.1186/s12978-020-00995-8Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocolGeorge Uchenna Eleje0Ikechukwu Innocent Mbachu1Uchenna Chukwunonso Ogwaluonye2Stephen Okoroafor Kalu3Chinyere Ukamaka Onubogu4Sussan Ifeyinwa Nweje5Chinwe Elizabeth Uzochukwu6Chike Henry Nwankwo7Preye Owen Fiebai8Olabisi Morebise Loto9Godwin Otuodichinma Akaba10Hadiza Abdullahi Usman11Ayyuba Rabiu12Richard Obinwanne Egeonu13Odion Emmanuel Igue14Bukola Abimbola Adesoji15Chiamaka Henrietta Jibuaku16Prince Ogbonnia Aja17Chiamaka Perpetua Chidozie18Hadiza Sani Ibrahim19Fatima Ele Aliyu20Aisha Ismaila Numan21Ogbonna Dennis Okoro22Solace Amechi Omoruyi23Ijeoma Chioma Oppah24Ubong Inyang Anyang25Aishat Ahmed26Shirley Nneka Chukwurah27Osita Samuel Umeononihu28Rebecca Chinyelu Chukwuanukwu29Eric Okechukwu Umeh30Ekene Agatha Emeka31Chukwuanugo Nkemakonam Ogbuagu32Ibrahim Adamu Yakasai33Oliver Chukwujekwu Ezechi34Joseph Ifeanyichukwu Ikechebelu35Triplex infection in pregnancy collaboration groupDepartment of Obstetrics and Gynecology, Nnamdi Azikiwe UniversityDepartment of Obstetrics and Gynecology, Nnamdi Azikiwe UniversityDepartment of Pharmaceutical Sciences, Nnamdi Azikiwe UniversityHIV Care Laboratory/HIV Care Department, Nnamdi Azikiwe University Teaching HospitalDepartment of Paediatrics, Nnamdi Azikiwe UniversityDepartment of Nursing, Nnamdi Azikiwe University Teaching HospitalDepartment of Mass Communication, Nnamdi Azikiwe UniversityDepartment of Statistics, Nnamdi Azikiwe UniversityDepartment of Obstetrics and Gynecology, University of Port HarcourtDepartment of Obstetrics and Gynecology, Obafemi Awolowo UniversityDepartment of Obstetrics and Gynecology, University of AbujaDepartment of Obstetrics and Gynecology, University of MaiduguriDepartment of Obstetrics and Gynecology, Bayero UniversityDepartment of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching HospitalDepartment of Physiological Sciences, Obafemi Awolowo UniversityDepartment of Nursing, Obafemi Awolowo University Teaching Hospital ComplexDepartment of Pharmaceutical Sciences, Nnamdi Azikiwe UniversityImmunology Unit, Department of Medical Laboratory Science, Nnamdi Azikiwe UniversityImmunology Unit, Department of Medical Laboratory Science, Nnamdi Azikiwe UniversityDepartment of Obstetrics and Gynecology, Aminu Kano Teaching HospitalDepartment of Obstetrics and Gynecology, Aminu Kano Teaching HospitalDepartment of Obstetrics and Gynecology, University of Maiduguri Teaching HospitalDepartment of Parasitology & Entomology, Faculty of Veterinary Medicine, University of Maiduguri Borno StateDepartment of Obstetrics and Gynecology, University of Port Harcourt Teaching HospitalDepartment of Obstetrics and Gynecology, University of Port Harcourt Teaching HospitalDepartment of Obstetrics and Gynecology, University of Abuja Teaching HospitalDepartment of Obstetrics and Gynecology, University of Abuja Teaching HospitalDepartment of Medicine, Faculty of Medicine, Nnamdi Azikiwe UniversityDepartment of Obstetrics and Gynecology, Nnamdi Azikiwe UniversityImmunology Unit, Department of Medical Laboratory Science, Nnamdi Azikiwe UniversityDepartment of Radiology, Faculty of Medicine, Nnamdi Azikiwe UniversityDepartment of Family Medicine, Faculty of Medicine, Nnamdi Azikiwe UniversityDepartment of Medical Microbiology and Parasitology, Faculty of Medicine, Nnamdi Azikiwe UniversityDepartment of Obstetrics and Gynecology, Bayero UniversityNigerian Institute of Medical ResearchDepartment of Obstetrics and Gynecology, Nnamdi Azikiwe UniversityAbstract Background Nigeria contributes significantly to the global burden of HIV, Hepatitis B and C infections, either singly or in combinations, despite progress in HIV care regionally and globally. Although some limited data on mono infection of HIV, Hepatitis B and C virus infections do exists, that of dual and triplex infections, including seroconversion and mother-to-child transmission (MTCT) rates necessary for planning to address the scourge of infections in pregnancy are not available. Objectives To determine the seroprevalence, rate of new infections, MTCT of dual and triple infections of HIV, Hepatitis B and C viruses and associated factors, among pregnant women in Nigeria. Method A multicenter prospective cohort study will be conducted in six tertiary health facilities randomly selected from the six geopolitical zones of Nigeria. All eligible pregnant women are to be tested at enrollment after informed consent for HIV, Hepatitis B and C virus infections. While those positive for at least two of the infections in any combination will be enrolled into the study and followed up to 6 weeks post-delivery, those negative for the three infections or positive for only one of the infections at enrolment will be retested at delivery using a rapid diagnostic test. On enrolment into the study relevant information, will be obtained, and laboratory test of CD4 count, liver function test and full blood counts, and prenatal ultrasonography will also be obtained/performed. Management of mother-newborns pairs will be according to appropriate national guidelines. All exposed newborns will be tested for HIV, HBV or HCV infection at birth and 6 weeks using PCR technique. The study data will be documented on the study case record forms. Data will be managed with SPSS for windows version 23. Ethical approval was obtained from National Health Research Ethics Committee (NHREC) (NHREC/01/01/2007–23/01/2020). Conclusion Pregnant women with multiple of HIV, HBV and HCV infections are at increased risk of hepatotoxicity, maternal and perinatal morbidity and mortality. Additionally, infected pregnant women transmit the virus to their unborn baby even when asymptomatic. Children born with any of the infection have significantly poorer quality of life and lower five-year survival rate. Unfortunately, the seroconversion and MTCT rates of dual or triplex infections among pregnant women in Nigeria have not been studied making planning for prevention and subsequent elimination of the viruses difficult. The study is expected to fill this knowledge gaps. Nigeria joining the rest of the world to eliminate the triple infection among children rest on the availability of adequate and reliable data generated from appropriately designed, and powered study using representative population sample. The establishment of the three-in-one study of prevalence, rate of new infection, rate and risk factor for MTCT of dual and triple infection of HIV, Hepatitis B and C viruses among pregnant women in Nigeria is urgently needed for policy development and planning for the improvement of the quality of life of mothers and the elimination of childhood triplex infection.http://link.springer.com/article/10.1186/s12978-020-00995-8Dual infectionHBVHCVHIVMultiple infectionNigeria |
| spellingShingle | George Uchenna Eleje Ikechukwu Innocent Mbachu Uchenna Chukwunonso Ogwaluonye Stephen Okoroafor Kalu Chinyere Ukamaka Onubogu Sussan Ifeyinwa Nweje Chinwe Elizabeth Uzochukwu Chike Henry Nwankwo Preye Owen Fiebai Olabisi Morebise Loto Godwin Otuodichinma Akaba Hadiza Abdullahi Usman Ayyuba Rabiu Richard Obinwanne Egeonu Odion Emmanuel Igue Bukola Abimbola Adesoji Chiamaka Henrietta Jibuaku Prince Ogbonnia Aja Chiamaka Perpetua Chidozie Hadiza Sani Ibrahim Fatima Ele Aliyu Aisha Ismaila Numan Ogbonna Dennis Okoro Solace Amechi Omoruyi Ijeoma Chioma Oppah Ubong Inyang Anyang Aishat Ahmed Shirley Nneka Chukwurah Osita Samuel Umeononihu Rebecca Chinyelu Chukwuanukwu Eric Okechukwu Umeh Ekene Agatha Emeka Chukwuanugo Nkemakonam Ogbuagu Ibrahim Adamu Yakasai Oliver Chukwujekwu Ezechi Joseph Ifeanyichukwu Ikechebelu Triplex infection in pregnancy collaboration group Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol Reproductive Health Dual infection HBV HCV HIV Multiple infection Nigeria |
| title | Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol |
| title_full | Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol |
| title_fullStr | Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol |
| title_full_unstemmed | Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol |
| title_short | Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol |
| title_sort | prevalence seroconversion and mother to child transmission of dual and triplex infections of hiv hepatitis b and c viruses among pregnant women in nigeria study protocol |
| topic | Dual infection HBV HCV HIV Multiple infection Nigeria |
| url | http://link.springer.com/article/10.1186/s12978-020-00995-8 |
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