Impact of the Olig Family on Neurodevelopmental Disorders
The Olig genes encode members of the basic helix-loop-helix (bHLH) family of transcription factors. Olig1, Olig2, and Olig3 are expressed in both the developing and mature central nervous system (CNS) and strictly regulate cellular specification and differentiation. Extensive studies have establishe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.659601/full |
| _version_ | 1818616879638380544 |
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| author | Jenny Szu Alexandre Wojcinski Peng Jiang Santosh Kesari Santosh Kesari |
| author_facet | Jenny Szu Alexandre Wojcinski Peng Jiang Santosh Kesari Santosh Kesari |
| author_sort | Jenny Szu |
| collection | DOAJ |
| description | The Olig genes encode members of the basic helix-loop-helix (bHLH) family of transcription factors. Olig1, Olig2, and Olig3 are expressed in both the developing and mature central nervous system (CNS) and strictly regulate cellular specification and differentiation. Extensive studies have established functional roles of Olig1 and Olig2 in directing neuronal and glial formation during different stages in development. Recently, Olig2 overexpression was implicated in neurodevelopmental disorders down syndrome (DS) and autism spectrum disorder (ASD) but its influence on cognitive and intellectual defects remains unknown. In this review, we summarize the biological functions of the Olig family and how it uniquely promotes cellular diversity in the CNS. This is followed up with a discussion on how abnormal Olig2 expression impacts brain development and function in DS and ASD. Collectively, the studies described here emphasize vital features of the Olig members and their distinctive potential roles in neurodevelopmental disease states. |
| first_indexed | 2024-12-16T16:56:49Z |
| format | Article |
| id | doaj.art-206496cca6874c26acb34929ab77cf67 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-16T16:56:49Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-206496cca6874c26acb34929ab77cf672022-12-21T22:23:52ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-03-011510.3389/fnins.2021.659601659601Impact of the Olig Family on Neurodevelopmental DisordersJenny Szu0Alexandre Wojcinski1Peng Jiang2Santosh Kesari3Santosh Kesari4Department of Translational Neurosciences and Neurotherapeutics, Saint John’s Cancer Institute, Providence Saint John’s Health Center, Santa Monica, CA, United StatesDepartment of Translational Neurosciences and Neurotherapeutics, Saint John’s Cancer Institute, Providence Saint John’s Health Center, Santa Monica, CA, United StatesDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, United StatesDepartment of Translational Neurosciences and Neurotherapeutics, Saint John’s Cancer Institute, Providence Saint John’s Health Center, Santa Monica, CA, United StatesPacific Neuroscience Institute, Providence Saint John’s Health Center, Santa Monica, CA, United StatesThe Olig genes encode members of the basic helix-loop-helix (bHLH) family of transcription factors. Olig1, Olig2, and Olig3 are expressed in both the developing and mature central nervous system (CNS) and strictly regulate cellular specification and differentiation. Extensive studies have established functional roles of Olig1 and Olig2 in directing neuronal and glial formation during different stages in development. Recently, Olig2 overexpression was implicated in neurodevelopmental disorders down syndrome (DS) and autism spectrum disorder (ASD) but its influence on cognitive and intellectual defects remains unknown. In this review, we summarize the biological functions of the Olig family and how it uniquely promotes cellular diversity in the CNS. This is followed up with a discussion on how abnormal Olig2 expression impacts brain development and function in DS and ASD. Collectively, the studies described here emphasize vital features of the Olig members and their distinctive potential roles in neurodevelopmental disease states.https://www.frontiersin.org/articles/10.3389/fnins.2021.659601/fullOligtranscription factorneurodevelopmentdown syndromeautism spectrum disorder |
| spellingShingle | Jenny Szu Alexandre Wojcinski Peng Jiang Santosh Kesari Santosh Kesari Impact of the Olig Family on Neurodevelopmental Disorders Frontiers in Neuroscience Olig transcription factor neurodevelopment down syndrome autism spectrum disorder |
| title | Impact of the Olig Family on Neurodevelopmental Disorders |
| title_full | Impact of the Olig Family on Neurodevelopmental Disorders |
| title_fullStr | Impact of the Olig Family on Neurodevelopmental Disorders |
| title_full_unstemmed | Impact of the Olig Family on Neurodevelopmental Disorders |
| title_short | Impact of the Olig Family on Neurodevelopmental Disorders |
| title_sort | impact of the olig family on neurodevelopmental disorders |
| topic | Olig transcription factor neurodevelopment down syndrome autism spectrum disorder |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.659601/full |
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