Custodiol versus Blood Cardioplegia: Comparison of Myocardial Immunohistochemical Analysis and Clinical Outcomes
ABSTRACT Introduction: Custodiol (histidine-tryptophan-ketoglutarate) and repetitive blood cardioplegia are the solutions for myocardial protection and cardiac arrest. In this study, we aimed to compare immunohistochemical analysis, clinical outcomes, and cardiac enzyme values of Custodiol and bloo...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Cirurgia Cardiovascular
2022-11-01
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| Series: | Brazilian Journal of Cardiovascular Surgery |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382022000500680&lng=en&tlng=en |
| _version_ | 1811220506173505536 |
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| author | Onur Sen Unal Aydin Ersin Kadirogullari Salih Güler Süheyla Gonca Seyhun Solakoğlu Mehmet Karaçalılar Barış Timur Burak Onan |
| author_facet | Onur Sen Unal Aydin Ersin Kadirogullari Salih Güler Süheyla Gonca Seyhun Solakoğlu Mehmet Karaçalılar Barış Timur Burak Onan |
| author_sort | Onur Sen |
| collection | DOAJ |
| description | ABSTRACT Introduction: Custodiol (histidine-tryptophan-ketoglutarate) and repetitive blood cardioplegia are the solutions for myocardial protection and cardiac arrest. In this study, we aimed to compare immunohistochemical analysis, clinical outcomes, and cardiac enzyme values of Custodiol and blood cardioplegia groups. Methods: This was a randomized prospective study consisting of 2 groups and 20 patients, 10 patients for each group, who underwent mitral and mitral/tricuspid valve surgery. Group 1 was formed for Custodiol cardioplegia and group 2 for blood cardioplegia. Perioperative and postoperative cardiac events were recorded, cardiac enzymes were analyzed with intervals, and myocardial samples were taken for immunohistochemical analysis. Recorded data were statistically evaluated. Results: There was no significant difference for the Custodiol and blood cardioplegia groups in perioperative and postoperative cardiac performance and adverse events. Cardiac enzyme analysis showed no significant difference between groups. However, two parameters (eNOS, Bcl-2) were in favor of the Custodiol group in immunohistochemical studies. Custodiol performed better in cellular oxidative stress resistance and cellular viability. Conclusion: Clinical outcomes and cardiac enzyme analysis results were similar regarding myocardial protection. However, Custodiol performed better in the immunohistochemical analysis. |
| first_indexed | 2024-04-12T07:44:15Z |
| format | Article |
| id | doaj.art-20651dd88dc54229b1bd86bd1d3e9054 |
| institution | Directory Open Access Journal |
| issn | 1678-9741 |
| language | English |
| last_indexed | 2024-04-12T07:44:15Z |
| publishDate | 2022-11-01 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| record_format | Article |
| series | Brazilian Journal of Cardiovascular Surgery |
| spelling | doaj.art-20651dd88dc54229b1bd86bd1d3e90542022-12-22T03:41:45ZengSociedade Brasileira de Cirurgia CardiovascularBrazilian Journal of Cardiovascular Surgery1678-97412022-11-0137568068710.21470/1678-9741-2020-0662Custodiol versus Blood Cardioplegia: Comparison of Myocardial Immunohistochemical Analysis and Clinical OutcomesOnur Senhttps://orcid.org/0000-0001-6635-108XUnal AydinErsin KadirogullariSalih GülerSüheyla GoncaSeyhun SolakoğluMehmet KaraçalılarBarış TimurBurak OnanABSTRACT Introduction: Custodiol (histidine-tryptophan-ketoglutarate) and repetitive blood cardioplegia are the solutions for myocardial protection and cardiac arrest. In this study, we aimed to compare immunohistochemical analysis, clinical outcomes, and cardiac enzyme values of Custodiol and blood cardioplegia groups. Methods: This was a randomized prospective study consisting of 2 groups and 20 patients, 10 patients for each group, who underwent mitral and mitral/tricuspid valve surgery. Group 1 was formed for Custodiol cardioplegia and group 2 for blood cardioplegia. Perioperative and postoperative cardiac events were recorded, cardiac enzymes were analyzed with intervals, and myocardial samples were taken for immunohistochemical analysis. Recorded data were statistically evaluated. Results: There was no significant difference for the Custodiol and blood cardioplegia groups in perioperative and postoperative cardiac performance and adverse events. Cardiac enzyme analysis showed no significant difference between groups. However, two parameters (eNOS, Bcl-2) were in favor of the Custodiol group in immunohistochemical studies. Custodiol performed better in cellular oxidative stress resistance and cellular viability. Conclusion: Clinical outcomes and cardiac enzyme analysis results were similar regarding myocardial protection. However, Custodiol performed better in the immunohistochemical analysis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382022000500680&lng=en&tlng=enCustodiol-N solutionsCardioplegic SolutionsOxidative StressCardiac Surgical ProceduresHeart ArrestInducedImmunohistochemistry |
| spellingShingle | Onur Sen Unal Aydin Ersin Kadirogullari Salih Güler Süheyla Gonca Seyhun Solakoğlu Mehmet Karaçalılar Barış Timur Burak Onan Custodiol versus Blood Cardioplegia: Comparison of Myocardial Immunohistochemical Analysis and Clinical Outcomes Brazilian Journal of Cardiovascular Surgery Custodiol-N solutions Cardioplegic Solutions Oxidative Stress Cardiac Surgical Procedures Heart Arrest Induced Immunohistochemistry |
| title | Custodiol versus Blood Cardioplegia: Comparison of Myocardial Immunohistochemical Analysis and Clinical Outcomes |
| title_full | Custodiol versus Blood Cardioplegia: Comparison of Myocardial Immunohistochemical Analysis and Clinical Outcomes |
| title_fullStr | Custodiol versus Blood Cardioplegia: Comparison of Myocardial Immunohistochemical Analysis and Clinical Outcomes |
| title_full_unstemmed | Custodiol versus Blood Cardioplegia: Comparison of Myocardial Immunohistochemical Analysis and Clinical Outcomes |
| title_short | Custodiol versus Blood Cardioplegia: Comparison of Myocardial Immunohistochemical Analysis and Clinical Outcomes |
| title_sort | custodiol versus blood cardioplegia comparison of myocardial immunohistochemical analysis and clinical outcomes |
| topic | Custodiol-N solutions Cardioplegic Solutions Oxidative Stress Cardiac Surgical Procedures Heart Arrest Induced Immunohistochemistry |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382022000500680&lng=en&tlng=en |
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