Case Report: Eighteen Month Relapse- Free Survival Following Radical Multidisciplinary Oncological Treatment in a 68-Year-Old Male Patient With Histiocytic Sarcoma
IntroductionHistiocytic Sarcoma (HS) is a rare and aggressive malignancy, and patients can present with rapid tumor growth and invasion. The optimal diagnostic and therapeutic management is unknown since only a few cases have been published. Here we report a patient with histiocytic sarcoma of the r...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.633215/full |
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| author | Stefan Wehrmann Hagen Rudolph Dominikus Ernst Timo Siepmann Dorothea Kaltofen Mathias Hänel Lutz Mirow |
| author_facet | Stefan Wehrmann Hagen Rudolph Dominikus Ernst Timo Siepmann Dorothea Kaltofen Mathias Hänel Lutz Mirow |
| author_sort | Stefan Wehrmann |
| collection | DOAJ |
| description | IntroductionHistiocytic Sarcoma (HS) is a rare and aggressive malignancy, and patients can present with rapid tumor growth and invasion. The optimal diagnostic and therapeutic management is unknown since only a few cases have been published. Here we report a patient with histiocytic sarcoma of the right groin.CaseA 68 year-old male patient presented to our hospital with suspicion of a superinfected atheroma of the right groin. Computed tomography showed an abdominal tumor of unknown entity. Detailed assessment including immunohistochemically evaluation of biopsy material confirmed HS. The patient underwent radical tumor resection including compartment-resection of the right thigh. During five additional cycles of chemotherapy over a period of 1.5 years he remained relapse-free.SummaryDiagnostic work up and treatment of HS is challenging, as there is a paucity of clinical reports and lack of standard guidelines for care. In the present case report, aggressive multidisciplinary treatment resulted in good clinical outcome, however, further studies evaluating this approach in similar patients are needed. |
| first_indexed | 2024-12-21T01:26:59Z |
| format | Article |
| id | doaj.art-20655ac937344c82ac88b9e691fce7b1 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T01:26:59Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-20655ac937344c82ac88b9e691fce7b12022-12-21T19:20:28ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-06-011110.3389/fonc.2021.633215633215Case Report: Eighteen Month Relapse- Free Survival Following Radical Multidisciplinary Oncological Treatment in a 68-Year-Old Male Patient With Histiocytic SarcomaStefan Wehrmann0Hagen Rudolph1Dominikus Ernst2Timo Siepmann3Dorothea Kaltofen4Mathias Hänel5Lutz Mirow6Department of General and Visceral Surgery, Klinikum Chemnitz gemeinnützige Gesellschaft mit beschränkter Haftung (gGmbH), Chemnitz, GermanyDepartment of General and Visceral Surgery, Klinikum Chemnitz gemeinnützige Gesellschaft mit beschränkter Haftung (gGmbH), Chemnitz, GermanyDepartment of General and Visceral Surgery, Klinikum Chemnitz gemeinnützige Gesellschaft mit beschränkter Haftung (gGmbH), Chemnitz, GermanyDepartment of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, GermanyDepartment of General and Visceral Surgery, Klinikum Chemnitz gemeinnützige Gesellschaft mit beschränkter Haftung (gGmbH), Chemnitz, GermanyDepartment of Medical Oncology, Klinikum Chemnitz gemeinnützige Gesellschaft mit beschränkter Haftung (gGmbH), Chemnitz, GermanyDepartment of General and Visceral Surgery, Klinikum Chemnitz gemeinnützige Gesellschaft mit beschränkter Haftung (gGmbH), Chemnitz, GermanyIntroductionHistiocytic Sarcoma (HS) is a rare and aggressive malignancy, and patients can present with rapid tumor growth and invasion. The optimal diagnostic and therapeutic management is unknown since only a few cases have been published. Here we report a patient with histiocytic sarcoma of the right groin.CaseA 68 year-old male patient presented to our hospital with suspicion of a superinfected atheroma of the right groin. Computed tomography showed an abdominal tumor of unknown entity. Detailed assessment including immunohistochemically evaluation of biopsy material confirmed HS. The patient underwent radical tumor resection including compartment-resection of the right thigh. During five additional cycles of chemotherapy over a period of 1.5 years he remained relapse-free.SummaryDiagnostic work up and treatment of HS is challenging, as there is a paucity of clinical reports and lack of standard guidelines for care. In the present case report, aggressive multidisciplinary treatment resulted in good clinical outcome, however, further studies evaluating this approach in similar patients are needed.https://www.frontiersin.org/articles/10.3389/fonc.2021.633215/fullhistiocytic sarcoma (HS)surgical oncologic managementmultidisciplinary approachhistiocytic and dendritic cell neoplasmssarcoma – diagnosticspathology |
| spellingShingle | Stefan Wehrmann Hagen Rudolph Dominikus Ernst Timo Siepmann Dorothea Kaltofen Mathias Hänel Lutz Mirow Case Report: Eighteen Month Relapse- Free Survival Following Radical Multidisciplinary Oncological Treatment in a 68-Year-Old Male Patient With Histiocytic Sarcoma Frontiers in Oncology histiocytic sarcoma (HS) surgical oncologic management multidisciplinary approach histiocytic and dendritic cell neoplasms sarcoma – diagnostics pathology |
| title | Case Report: Eighteen Month Relapse- Free Survival Following Radical Multidisciplinary Oncological Treatment in a 68-Year-Old Male Patient With Histiocytic Sarcoma |
| title_full | Case Report: Eighteen Month Relapse- Free Survival Following Radical Multidisciplinary Oncological Treatment in a 68-Year-Old Male Patient With Histiocytic Sarcoma |
| title_fullStr | Case Report: Eighteen Month Relapse- Free Survival Following Radical Multidisciplinary Oncological Treatment in a 68-Year-Old Male Patient With Histiocytic Sarcoma |
| title_full_unstemmed | Case Report: Eighteen Month Relapse- Free Survival Following Radical Multidisciplinary Oncological Treatment in a 68-Year-Old Male Patient With Histiocytic Sarcoma |
| title_short | Case Report: Eighteen Month Relapse- Free Survival Following Radical Multidisciplinary Oncological Treatment in a 68-Year-Old Male Patient With Histiocytic Sarcoma |
| title_sort | case report eighteen month relapse free survival following radical multidisciplinary oncological treatment in a 68 year old male patient with histiocytic sarcoma |
| topic | histiocytic sarcoma (HS) surgical oncologic management multidisciplinary approach histiocytic and dendritic cell neoplasms sarcoma – diagnostics pathology |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.633215/full |
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