GT1b-induced neurotoxicity is mediated by the Akt/GSK-3/tau signaling pathway but not caspase-3 in mesencephalic dopaminergic neurons

GT1b-induced neurotoxicity is mediated by the Akt/GSK-3/tau signaling pathway but not caspase-3 in mesencephalic dopaminergic neurons

<p>Abstract</p> <p>Background</p> <p>Gangliosides, sialic acid-containing glycosphingolipids exist in mammalian cell membranes particularly neuronal membranes. The trisialoganglioside (GT1b) is one of the major brain gangliosides and acts as an endogenous regulator in t...

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Bibliographic Details
Main Authors:	Sohn Sunghyang, Bok Eugene, Chung Eun S, Lee Young D, Baik Hyung H, Jin Byung K
Format:	Article
Language:	English
Published:	BMC 2010-06-01
Series:	BMC Neuroscience
Online Access:	http://www.biomedcentral.com/1471-2202/11/74

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