Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media
The stability constant of Efavirenz drug with alkaline earth metal ions Mg(II), Ca(II) and transition metal ions Fe(III), Cu(II) were investigate using pH metric titration technique in 20%(v/v) ethanol-water mixture at 27 °C temperature and at an ionic strength of 0.1M NaClO4.{Metal to ligand ratio...
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| Format: | Article |
| Language: | English |
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PURKH
2020-06-01
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| Series: | To Chemistry Journal |
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| Online Access: | https://purkh.com/index.php/tochem/article/view/769 |
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| author | Ramesh Ware D. B. Jirekar P. P. Ghumare Shailendrasingh Thakur |
| author_facet | Ramesh Ware D. B. Jirekar P. P. Ghumare Shailendrasingh Thakur |
| author_sort | Ramesh Ware |
| collection | DOAJ |
| description | The stability constant of Efavirenz drug with alkaline earth metal ions Mg(II), Ca(II) and transition metal ions Fe(III), Cu(II) were investigate using pH metric titration technique in 20%(v/v) ethanol-water mixture at 27 °C temperature and at an ionic strength of 0.1M NaClO4.{Metal to ligand ratio = 1:5 & 1:1}The method of Calvin and Bjerrum as adopted by Irving and Rossotti has been employed to determine proton ligand (pKa) and metal-ligand stability constants (log K) values. It is observed that alkaline earth metal & transition metal ion forms 1:1 and 1:2 complexes. The order of stability constants for these metal complexes was as: Fe3+ > Cu2+ > Mg2+ > Ca2+ |
| first_indexed | 2024-12-20T00:32:27Z |
| format | Article |
| id | doaj.art-20670ea5ec534e33a982a726ef9c5009 |
| institution | Directory Open Access Journal |
| issn | 2581-7507 |
| language | English |
| last_indexed | 2024-12-20T00:32:27Z |
| publishDate | 2020-06-01 |
| publisher | PURKH |
| record_format | Article |
| series | To Chemistry Journal |
| spelling | doaj.art-20670ea5ec534e33a982a726ef9c50092022-12-21T19:59:53ZengPURKHTo Chemistry Journal2581-75072020-06-016Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water MediaRamesh Ware0D. B. Jirekar1P. P. Ghumare2Shailendrasingh Thakur3Milliya College, Beed. (India)Anandrao Dhonde College, Kada, Dist. Beed. (India)Anandrao Dhonde College, Kada, Dist. Beed. (India)Milliya College, Beed. (India)The stability constant of Efavirenz drug with alkaline earth metal ions Mg(II), Ca(II) and transition metal ions Fe(III), Cu(II) were investigate using pH metric titration technique in 20%(v/v) ethanol-water mixture at 27 °C temperature and at an ionic strength of 0.1M NaClO4.{Metal to ligand ratio = 1:5 & 1:1}The method of Calvin and Bjerrum as adopted by Irving and Rossotti has been employed to determine proton ligand (pKa) and metal-ligand stability constants (log K) values. It is observed that alkaline earth metal & transition metal ion forms 1:1 and 1:2 complexes. The order of stability constants for these metal complexes was as: Fe3+ > Cu2+ > Mg2+ > Ca2+https://purkh.com/index.php/tochem/article/view/769pH metryEfavirenz transition metalalkaline earth metalStability Constant |
| spellingShingle | Ramesh Ware D. B. Jirekar P. P. Ghumare Shailendrasingh Thakur Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media To Chemistry Journal pH metry Efavirenz transition metal alkaline earth metal Stability Constant |
| title | Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media |
| title_full | Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media |
| title_fullStr | Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media |
| title_full_unstemmed | Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media |
| title_short | Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media |
| title_sort | formation of alkaline earth and transition metal complexes with efavirenz drug in ethanol water media |
| topic | pH metry Efavirenz transition metal alkaline earth metal Stability Constant |
| url | https://purkh.com/index.php/tochem/article/view/769 |
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