N,N’ bis-(2-mercaptoethyl) isophthalamide induces developmental delay in Caenorhabditis elegans by promoting DAF-16 nuclear localization

N,N’ bis-(2-mercaptoethyl) isophthalamide induces developmental delay in Caenorhabditis elegans by promoting DAF-16 nuclear localization

N,N’ bis-(2-mercaptoethyl) isophthalamide (NBMI) is a lipophilic thiol-containing agent that has high affinity for toxic metal ions, such as Hg2+, Pb2+, and Cd2+. Studies have shown that NBMI is a potent chelator of heavy metals, yet its potential toxicity in animals has yet to be determined. Using...

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Bibliographic Details
Main Authors: Tao Ke, Félix Alexandre Antunes Soares, Abel Santamaría, Aaron B. Bowman, Anatoly V. Skalny, Michael Aschner
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Toxicology Reports
Subjects:
Chelation
Developmental delay
Methylmercury
C. elegans
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750020303577

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