Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in rats
ABSTRACT Purpose To evaluate the efficacy of hypertonic glucose (10%), alone or in combination with the corticoid dexamethasone, to prevent peritoneal adhesion following hysterectomy in rats. Methods Forty-two adult rats underwent hysterectomy with peritoneal lavage: G1 – glucose (10%); G2 – gluco...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2021-06-01
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| Series: | Acta Cirúrgica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000500206&tlng=en |
| _version_ | 1819106270411489280 |
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| author | João Nogueira Neto Alexandra de Oliveira do Carmo Laura Sales Carvalho Lima Lyvia Maria Rodrigues de Sousa Gomes Ed Carlos Rey Moura Caio Marcio Barros de Oliveira Thiers Soares Raymundo George Castro Figueira de Melo Plinio da Cunha Leal |
| author_facet | João Nogueira Neto Alexandra de Oliveira do Carmo Laura Sales Carvalho Lima Lyvia Maria Rodrigues de Sousa Gomes Ed Carlos Rey Moura Caio Marcio Barros de Oliveira Thiers Soares Raymundo George Castro Figueira de Melo Plinio da Cunha Leal |
| author_sort | João Nogueira Neto |
| collection | DOAJ |
| description | ABSTRACT Purpose To evaluate the efficacy of hypertonic glucose (10%), alone or in combination with the corticoid dexamethasone, to prevent peritoneal adhesion following hysterectomy in rats. Methods Forty-two adult rats underwent hysterectomy with peritoneal lavage: G1 – glucose (10%); G2 – glucose (10%) and dexamethasone 3 mg·kg–1; and G3 – physiological saline (PS) 0.9%. Results In the macroscopic analysis after 14 days, G1 had a median score of 1, G2 of 1, and G3 of 2.5 (p < 0.0001), G3 compared to G1 and G2. There was no difference between groups after 28 days. In the microscopic analysis, the median vascular proliferation after 14 days was 2 for G1, 1 for G2, and 3 for G3 (p = 0.0037, G3 vs. G1 and G2). After 28 days, G1 showed a median vascular proliferation score of 2, G2 of 2.5, and G3 of 3 (p < 0.0001, G3 vs. G1 and G2). Regarding the inflammatory reaction after 14 days, G1 had a median score of 2, G2 of 1, and G3 of 3 (p = 0.7916). After 28 days, G1 had a median score of 0.5 (0–1.75), G2 of 1.5, and G3 of 2.5 (p < 0.0001, G3 vs. the others and G2 vs. G1). In the evaluation of fibrosis after 14 days, G1 had a median score of 1, G2 of 1, and G3 of 2.5 (p < 0.0001, G3 vs. G1and G2). After 28 days, G1 had a median fibrosis score of 1, G2: 2, and G3: 2.5 (p < 0.0001), G3 vs. the others andG2 vs. G1). Conclusions The use of hypertonic glucose (10%) solution seems to reduce macroscopic and microscopic pelvic adhesions. |
| first_indexed | 2024-12-22T02:35:28Z |
| format | Article |
| id | doaj.art-20687c73c76a4588a93e2523d97271be |
| institution | Directory Open Access Journal |
| issn | 0102-8650 |
| language | English |
| last_indexed | 2024-12-22T02:35:28Z |
| publishDate | 2021-06-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj.art-20687c73c76a4588a93e2523d97271be2022-12-21T18:41:47ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira0102-86502021-06-0136510.1590/acb360504Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in ratsJoão Nogueira Netohttps://orcid.org/0000-0002-9164-704XAlexandra de Oliveira do Carmohttps://orcid.org/0000-0003-2886-0742Laura Sales Carvalho Limahttps://orcid.org/0000-0002-8595-4262Lyvia Maria Rodrigues de Sousa Gomeshttps://orcid.org/0000-0002-4786-1110Ed Carlos Rey Mourahttps://orcid.org/0000-0002-7752-0683Caio Marcio Barros de Oliveirahttps://orcid.org/0000-0002-5068-9067Thiers Soares Raymundohttps://orcid.org/0000-0003-4411-4504George Castro Figueira de Melohttps://orcid.org/0000-0002-3276-6356Plinio da Cunha Lealhttps://orcid.org/0000-0003-1336-8528ABSTRACT Purpose To evaluate the efficacy of hypertonic glucose (10%), alone or in combination with the corticoid dexamethasone, to prevent peritoneal adhesion following hysterectomy in rats. Methods Forty-two adult rats underwent hysterectomy with peritoneal lavage: G1 – glucose (10%); G2 – glucose (10%) and dexamethasone 3 mg·kg–1; and G3 – physiological saline (PS) 0.9%. Results In the macroscopic analysis after 14 days, G1 had a median score of 1, G2 of 1, and G3 of 2.5 (p < 0.0001), G3 compared to G1 and G2. There was no difference between groups after 28 days. In the microscopic analysis, the median vascular proliferation after 14 days was 2 for G1, 1 for G2, and 3 for G3 (p = 0.0037, G3 vs. G1 and G2). After 28 days, G1 showed a median vascular proliferation score of 2, G2 of 2.5, and G3 of 3 (p < 0.0001, G3 vs. G1 and G2). Regarding the inflammatory reaction after 14 days, G1 had a median score of 2, G2 of 1, and G3 of 3 (p = 0.7916). After 28 days, G1 had a median score of 0.5 (0–1.75), G2 of 1.5, and G3 of 2.5 (p < 0.0001, G3 vs. the others and G2 vs. G1). In the evaluation of fibrosis after 14 days, G1 had a median score of 1, G2 of 1, and G3 of 2.5 (p < 0.0001, G3 vs. G1and G2). After 28 days, G1 had a median fibrosis score of 1, G2: 2, and G3: 2.5 (p < 0.0001), G3 vs. the others andG2 vs. G1). Conclusions The use of hypertonic glucose (10%) solution seems to reduce macroscopic and microscopic pelvic adhesions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000500206&tlng=enTissue AdhesionsGlucose SolutionHypertonicDexamethasone |
| spellingShingle | João Nogueira Neto Alexandra de Oliveira do Carmo Laura Sales Carvalho Lima Lyvia Maria Rodrigues de Sousa Gomes Ed Carlos Rey Moura Caio Marcio Barros de Oliveira Thiers Soares Raymundo George Castro Figueira de Melo Plinio da Cunha Leal Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in rats Acta Cirúrgica Brasileira Tissue Adhesions Glucose Solution Hypertonic Dexamethasone |
| title | Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in rats |
| title_full | Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in rats |
| title_fullStr | Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in rats |
| title_full_unstemmed | Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in rats |
| title_short | Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in rats |
| title_sort | use of hypertonic glucose 10 in the prevention of postoperative adhesions in rats |
| topic | Tissue Adhesions Glucose Solution Hypertonic Dexamethasone |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000500206&tlng=en |
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