Myelomatous pleural effusion in a cat diagnosed with multiple myeloma
Case summary A 10-year-old male castrated domestic shorthair cat was presented with a 3-day history of dyspnoea, chronic lethargy and inappetence. A bilateral pleural effusion was identified by thoracic ultrasound, and cytological examination revealed numerous atypical plasma cells. Biochemistry and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-02-01
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| Series: | Journal of Feline Medicine and Surgery Open Reports |
| Online Access: | https://doi.org/10.1177/20551169221134094 |
| _version_ | 1797934945849573376 |
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| author | Tancrède Amalbert Aude Morgane Canonne Jérémy Béguin |
| author_facet | Tancrède Amalbert Aude Morgane Canonne Jérémy Béguin |
| author_sort | Tancrède Amalbert |
| collection | DOAJ |
| description | Case summary A 10-year-old male castrated domestic shorthair cat was presented with a 3-day history of dyspnoea, chronic lethargy and inappetence. A bilateral pleural effusion was identified by thoracic ultrasound, and cytological examination revealed numerous atypical plasma cells. Biochemistry and serum protein electrophoresis revealed a severe hyperglobulinaemia associated with a monoclonal gammopathy. A moderate non-regenerative anaemia was also noted. Multiple bone lytic lesions were detected, and marked plasmacytosis was observed on bone marrow aspirates. Chemotherapy with cyclophosphamide and prednisolone was initiated but did not result in any clinical or biological response, and pleural effusion recurred. Lack of therapeutic response led to euthanasia 2 months after diagnosis. Relevance and novel information This is the first description of a myelomatous pleural effusion in a cat diagnosed with multiple myeloma and should be considered as one of the possible differential diagnoses for cats presented with pleural effusion and hyperglobulinaemia. The diagnostic, therapeutic and prognostic aspects of this manifestation are discussed. |
| first_indexed | 2024-04-10T18:06:50Z |
| format | Article |
| id | doaj.art-2069c521629e4421995678229b9845b3 |
| institution | Directory Open Access Journal |
| issn | 2055-1169 |
| language | English |
| last_indexed | 2024-04-10T18:06:50Z |
| publishDate | 2023-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Feline Medicine and Surgery Open Reports |
| spelling | doaj.art-2069c521629e4421995678229b9845b32023-02-02T12:33:34ZengSAGE PublishingJournal of Feline Medicine and Surgery Open Reports2055-11692023-02-01910.1177/20551169221134094Myelomatous pleural effusion in a cat diagnosed with multiple myelomaTancrède Amalbert0Aude Morgane Canonne1Jérémy Béguin2National Veterinary School of Alfort, Paris-Est University, Maisons-Alfort, FranceDepartment of Internal Medicine, National Veterinary School of Alfort, Paris-Est University, Maisons-Alfort, FranceDepartment of Internal Medicine, National Veterinary School of Alfort, Paris-Est University, Maisons-Alfort, FranceCase summary A 10-year-old male castrated domestic shorthair cat was presented with a 3-day history of dyspnoea, chronic lethargy and inappetence. A bilateral pleural effusion was identified by thoracic ultrasound, and cytological examination revealed numerous atypical plasma cells. Biochemistry and serum protein electrophoresis revealed a severe hyperglobulinaemia associated with a monoclonal gammopathy. A moderate non-regenerative anaemia was also noted. Multiple bone lytic lesions were detected, and marked plasmacytosis was observed on bone marrow aspirates. Chemotherapy with cyclophosphamide and prednisolone was initiated but did not result in any clinical or biological response, and pleural effusion recurred. Lack of therapeutic response led to euthanasia 2 months after diagnosis. Relevance and novel information This is the first description of a myelomatous pleural effusion in a cat diagnosed with multiple myeloma and should be considered as one of the possible differential diagnoses for cats presented with pleural effusion and hyperglobulinaemia. The diagnostic, therapeutic and prognostic aspects of this manifestation are discussed.https://doi.org/10.1177/20551169221134094 |
| spellingShingle | Tancrède Amalbert Aude Morgane Canonne Jérémy Béguin Myelomatous pleural effusion in a cat diagnosed with multiple myeloma Journal of Feline Medicine and Surgery Open Reports |
| title | Myelomatous pleural effusion in a cat diagnosed with multiple myeloma |
| title_full | Myelomatous pleural effusion in a cat diagnosed with multiple myeloma |
| title_fullStr | Myelomatous pleural effusion in a cat diagnosed with multiple myeloma |
| title_full_unstemmed | Myelomatous pleural effusion in a cat diagnosed with multiple myeloma |
| title_short | Myelomatous pleural effusion in a cat diagnosed with multiple myeloma |
| title_sort | myelomatous pleural effusion in a cat diagnosed with multiple myeloma |
| url | https://doi.org/10.1177/20551169221134094 |
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