SOCS1 gene mutations in patients with diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of diseases, which accounts for 30% of all non-Hodgkin lymphomas. Current molecular studies have confirmed that there are several DLBCL subtypes characterized by different cellular origin, cytogenetic profile, molecular genetic disorders...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2015-07-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31812 |
| _version_ | 1818408836034199552 |
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| author | O A Gavrilina E E Zvonkov B V Biderman N A Severina E N Parovichnikova |
| author_facet | O A Gavrilina E E Zvonkov B V Biderman N A Severina E N Parovichnikova |
| author_sort | O A Gavrilina |
| collection | DOAJ |
| description | Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of diseases, which accounts for 30% of all non-Hodgkin lymphomas. Current molecular studies have confirmed that there are several DLBCL subtypes characterized by different cellular origin, cytogenetic profile, molecular genetic disorders, and different pathogenesis. Impaired JAK-STAT signaling is a part of the pathogenesis of various cancers, including DLBCL. The review deals with the molecular genetic aspects of the occurrence of DLBCL and the function of the SOCS1 gene that has been proven to be responsible for the development of several cancers. Mutations of this gene result from spontaneously impaired B-cell somatic hypermutation and they are frequently inactivating. The presence of point mutations in the functionally significant region of this gene in DLBCL could identify a group of patients with poor prognosis during standard chemotherapy. |
| first_indexed | 2024-12-14T09:50:03Z |
| format | Article |
| id | doaj.art-206b600d3535452e9856f93fc73aa8cd |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-14T09:50:03Z |
| publishDate | 2015-07-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-206b600d3535452e9856f93fc73aa8cd2022-12-21T23:07:33Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422015-07-0187710511128827SOCS1 gene mutations in patients with diffuse large B-cell lymphomaO A GavrilinaE E ZvonkovB V BidermanN A SeverinaE N ParovichnikovaDiffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of diseases, which accounts for 30% of all non-Hodgkin lymphomas. Current molecular studies have confirmed that there are several DLBCL subtypes characterized by different cellular origin, cytogenetic profile, molecular genetic disorders, and different pathogenesis. Impaired JAK-STAT signaling is a part of the pathogenesis of various cancers, including DLBCL. The review deals with the molecular genetic aspects of the occurrence of DLBCL and the function of the SOCS1 gene that has been proven to be responsible for the development of several cancers. Mutations of this gene result from spontaneously impaired B-cell somatic hypermutation and they are frequently inactivating. The presence of point mutations in the functionally significant region of this gene in DLBCL could identify a group of patients with poor prognosis during standard chemotherapy.https://ter-arkhiv.ru/0040-3660/article/view/31812diffuse large b-cell lymphomasocs1 genechemotherapypoor predictors |
| spellingShingle | O A Gavrilina E E Zvonkov B V Biderman N A Severina E N Parovichnikova SOCS1 gene mutations in patients with diffuse large B-cell lymphoma Терапевтический архив diffuse large b-cell lymphoma socs1 gene chemotherapy poor predictors |
| title | SOCS1 gene mutations in patients with diffuse large B-cell lymphoma |
| title_full | SOCS1 gene mutations in patients with diffuse large B-cell lymphoma |
| title_fullStr | SOCS1 gene mutations in patients with diffuse large B-cell lymphoma |
| title_full_unstemmed | SOCS1 gene mutations in patients with diffuse large B-cell lymphoma |
| title_short | SOCS1 gene mutations in patients with diffuse large B-cell lymphoma |
| title_sort | socs1 gene mutations in patients with diffuse large b cell lymphoma |
| topic | diffuse large b-cell lymphoma socs1 gene chemotherapy poor predictors |
| url | https://ter-arkhiv.ru/0040-3660/article/view/31812 |
| work_keys_str_mv | AT oagavrilina socs1genemutationsinpatientswithdiffuselargebcelllymphoma AT eezvonkov socs1genemutationsinpatientswithdiffuselargebcelllymphoma AT bvbiderman socs1genemutationsinpatientswithdiffuselargebcelllymphoma AT naseverina socs1genemutationsinpatientswithdiffuselargebcelllymphoma AT enparovichnikova socs1genemutationsinpatientswithdiffuselargebcelllymphoma |