Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study)
OBJECTIVES: The etiology of testicular germ cell tumors (TGCT) is suspected to be related to prenatal environmental risk factors. Some solvents have potential endocrine disrupting or carcinogenic properties and may disrupt male genital development in utero. The aim of this study was to examine the a...
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| Format: | Article |
| Language: | English |
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Nordic Association of Occupational Safety and Health (NOROSH)
2023-09-01
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| Series: | Scandinavian Journal of Work, Environment & Health |
| Subjects: | |
| Online Access: |
https://www.sjweh.fi/article/4102
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| _version_ | 1797730932197687296 |
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| author | Margot Guth Marie Lefevre Corinne Pilorget Astrid Coste Shukrullah Ahmadi Aurélie Danjou Brigitte Dananché Delphine Praud Isabelle Koscinski Aline Papaxanthos Oxana Blagosklonov Patricia Fauque Olivia Pérol Joachim Schüz Louis Bujan Ann Olsson Béatrice Fervers Barbara Charbotel The TESTIS study group |
| author_facet | Margot Guth Marie Lefevre Corinne Pilorget Astrid Coste Shukrullah Ahmadi Aurélie Danjou Brigitte Dananché Delphine Praud Isabelle Koscinski Aline Papaxanthos Oxana Blagosklonov Patricia Fauque Olivia Pérol Joachim Schüz Louis Bujan Ann Olsson Béatrice Fervers Barbara Charbotel The TESTIS study group |
| author_sort | Margot Guth |
| collection | DOAJ |
| description | OBJECTIVES: The etiology of testicular germ cell tumors (TGCT) is suspected to be related to prenatal environmental risk factors. Some solvents have potential endocrine disrupting or carcinogenic properties and may disrupt male genital development in utero. The aim of this study was to examine the association between parental occupational exposure to solvents and TGCT risk among their offspring. METHODS: A French nationwide case–control study, TESTIS included 454 TGCT cases and 670 controls frequency-matched on region and 5-year age strata. Participants were interviewed via telephone and provided information on parental occupations at birth. Job-exposure matrices (JEM) developed in the French Matgéné program were used to assign exposure to five petroleum-based solvents, five solvents or groups of oxygenated solvents, and five chlorinated solvents. Odds ratios (OR) for TGCT and 95% confidence intervals (CI) were estimated using conditional logistic regression, adjusting for TGCT risk factors. RESULTS: Occupational exposure to at least one solvent during the year of their son’s birth was 41% among fathers and 21% among mothers. Paternal exposure to at least one solvent showed OR 0.89 (95% CI 0.68–1.15). Exposure to perchloroethylene (OR 1.41, 95% CI 0.55–3.61), methylene chloride (OR 1.13, 95% CI 0.54–2.34) and diesel/kerosene/fuel oil (OR 1.17, 95% CI 0.80–1.73) disclosed OR >1 but with low precision. Our results suggest a possible modest increase in non-seminoma risk for sons whose fathers were highly exposed to trichloroethylene (OR 1.44, 95% CI 0.79–2.63). Maternal exposure to at least one solvent showed OR 0.90 (95% CI 0.65–1.24). When stratifying by birth year, men born in the 1970s experienced an increased TGCT risk following maternal exposure to fuels and petroleum-based solvents (OR 2.74, 95% CI 1.11–6.76). CONCLUSION: Overall, no solid association was found between parental occupational exposure to solvents and TGCT risk. The association found with maternal occupational exposure to fuels and petroleum solvents among older men needs further investigation. |
| first_indexed | 2024-03-12T11:52:13Z |
| format | Article |
| id | doaj.art-206be3fd2d234352b8ea18fb59237882 |
| institution | Directory Open Access Journal |
| issn | 0355-3140 1795-990X |
| language | English |
| last_indexed | 2024-03-12T11:52:13Z |
| publishDate | 2023-09-01 |
| publisher | Nordic Association of Occupational Safety and Health (NOROSH) |
| record_format | Article |
| series | Scandinavian Journal of Work, Environment & Health |
| spelling | doaj.art-206be3fd2d234352b8ea18fb592378822023-08-31T06:18:04ZengNordic Association of Occupational Safety and Health (NOROSH)Scandinavian Journal of Work, Environment & Health0355-31401795-990X2023-09-0149640541810.5271/sjweh.41024102Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study)Margot GuthMarie LefevreCorinne PilorgetAstrid CosteShukrullah AhmadiAurélie DanjouBrigitte DananchéDelphine PraudIsabelle KoscinskiAline PapaxanthosOxana BlagosklonovPatricia FauqueOlivia PérolJoachim SchüzLouis BujanAnn OlssonBéatrice Fervers0Barbara CharbotelThe TESTIS study groupPrevention Cancer Environnement Departement, Centre Léon Bérard, Lyon, France.OBJECTIVES: The etiology of testicular germ cell tumors (TGCT) is suspected to be related to prenatal environmental risk factors. Some solvents have potential endocrine disrupting or carcinogenic properties and may disrupt male genital development in utero. The aim of this study was to examine the association between parental occupational exposure to solvents and TGCT risk among their offspring. METHODS: A French nationwide case–control study, TESTIS included 454 TGCT cases and 670 controls frequency-matched on region and 5-year age strata. Participants were interviewed via telephone and provided information on parental occupations at birth. Job-exposure matrices (JEM) developed in the French Matgéné program were used to assign exposure to five petroleum-based solvents, five solvents or groups of oxygenated solvents, and five chlorinated solvents. Odds ratios (OR) for TGCT and 95% confidence intervals (CI) were estimated using conditional logistic regression, adjusting for TGCT risk factors. RESULTS: Occupational exposure to at least one solvent during the year of their son’s birth was 41% among fathers and 21% among mothers. Paternal exposure to at least one solvent showed OR 0.89 (95% CI 0.68–1.15). Exposure to perchloroethylene (OR 1.41, 95% CI 0.55–3.61), methylene chloride (OR 1.13, 95% CI 0.54–2.34) and diesel/kerosene/fuel oil (OR 1.17, 95% CI 0.80–1.73) disclosed OR >1 but with low precision. Our results suggest a possible modest increase in non-seminoma risk for sons whose fathers were highly exposed to trichloroethylene (OR 1.44, 95% CI 0.79–2.63). Maternal exposure to at least one solvent showed OR 0.90 (95% CI 0.65–1.24). When stratifying by birth year, men born in the 1970s experienced an increased TGCT risk following maternal exposure to fuels and petroleum-based solvents (OR 2.74, 95% CI 1.11–6.76). CONCLUSION: Overall, no solid association was found between parental occupational exposure to solvents and TGCT risk. The association found with maternal occupational exposure to fuels and petroleum solvents among older men needs further investigation. https://www.sjweh.fi/article/4102 epidemiologyoccupational exposuresolventorganic solventcancerjob-exposure matrixparental exposureparental occupational exposurejemprenatal exposuretesticular germ cell tumortestis studytesticular cancer |
| spellingShingle | Margot Guth Marie Lefevre Corinne Pilorget Astrid Coste Shukrullah Ahmadi Aurélie Danjou Brigitte Dananché Delphine Praud Isabelle Koscinski Aline Papaxanthos Oxana Blagosklonov Patricia Fauque Olivia Pérol Joachim Schüz Louis Bujan Ann Olsson Béatrice Fervers Barbara Charbotel The TESTIS study group Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study) Scandinavian Journal of Work, Environment & Health epidemiology occupational exposure solvent organic solvent cancer job-exposure matrix parental exposure parental occupational exposure jem prenatal exposure testicular germ cell tumor testis study testicular cancer |
| title | Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study) |
| title_full | Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study) |
| title_fullStr | Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study) |
| title_full_unstemmed | Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study) |
| title_short | Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study) |
| title_sort | parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons a french nationwide case control study testis study |
| topic | epidemiology occupational exposure solvent organic solvent cancer job-exposure matrix parental exposure parental occupational exposure jem prenatal exposure testicular germ cell tumor testis study testicular cancer |
| url |
https://www.sjweh.fi/article/4102
|
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