Dosimetric validation of two different radiobiological models for parotid gland functionality of tongue cancer
Abstract Objective The aim of this study was to investigate the normal tissue complication probability (NTCP) for parotid gland of ca tongue patients from two different radiobiological models and to establish a dosimetric validity. Methods Lyman–Kutcher–Burman (LKB) model and linear quadratic (LQ) m...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-09-01
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| Series: | Precision Radiation Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/pro6.1130 |
| _version_ | 1831592618183622656 |
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| author | Srimanta Pramanik Soumen Bera Sanjoy Roy Amitabh Ray Sandip Sarkar Dipanjan Majumder |
| author_facet | Srimanta Pramanik Soumen Bera Sanjoy Roy Amitabh Ray Sandip Sarkar Dipanjan Majumder |
| author_sort | Srimanta Pramanik |
| collection | DOAJ |
| description | Abstract Objective The aim of this study was to investigate the normal tissue complication probability (NTCP) for parotid gland of ca tongue patients from two different radiobiological models and to establish a dosimetric validity. Methods Lyman–Kutcher–Burman (LKB) model and linear quadratic (LQ) model were considered for determination of NTCP and tolerance dose (TD5/5 and TD50/5) for the parotid gland of 67 number of ca tongue patients who were treated with the volumetric arc therapy (VMAT) technique. An in‐house developed software on Excel (VBA) was used for this study. Results The equivalent uniform dose (EUD) was linearly proportional to the effective volume (veff) for parotid glands and there was a strong correlation between EUD and veff. At EUD = 46 to 47 Gy, the NTCP of parotid was 0.5 for both the models. The tolerance doses, TD5/5 (veff) and TD50/5 (veff) were exponentially reduced with increase of veff for LKB model; whereas these parameters were volume‐independent in the LQ model. TD5/5 (veff) and TD50/5 (veff) were 31.98 Gy and 45.98 Gy respectively for all 67 patients in the LQ model. Below TD50/5, NTCP of LKB model was less than the NTCP , calculated from LQ model. Conclusion One may consider radiobiological LQ model for estimation of clinical tolerance dose for OARs. Due to lack of clinical data, there are inaccuracy in determination of NTCP from LQ model. If sufficient number of tolerance data for partial volumes are available, the prediction of NTCP would be more confident. |
| first_indexed | 2024-12-18T01:45:56Z |
| format | Article |
| id | doaj.art-206d5aaf1cbe4c36a0dffd8cf104e2a5 |
| institution | Directory Open Access Journal |
| issn | 2398-7324 |
| language | English |
| last_indexed | 2024-12-18T01:45:56Z |
| publishDate | 2021-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Precision Radiation Oncology |
| spelling | doaj.art-206d5aaf1cbe4c36a0dffd8cf104e2a52022-12-21T21:25:10ZengWileyPrecision Radiation Oncology2398-73242021-09-015318319010.1002/pro6.1130Dosimetric validation of two different radiobiological models for parotid gland functionality of tongue cancerSrimanta Pramanik0Soumen Bera1Sanjoy Roy2Amitabh Ray3Sandip Sarkar4Dipanjan Majumder5Department of Radiation Oncology Ruby General Hospital E.M. Bypass, Kasba, Golpark Kolkata West Bengal IndiaDepartment of Radiation Oncology Ruby General Hospital E.M. Bypass, Kasba, Golpark Kolkata West Bengal IndiaDepartment of Radiation Oncology Ruby General Hospital E.M. Bypass, Kasba, Golpark Kolkata West Bengal IndiaDepartment of Radiation Oncology Ruby General Hospital E.M. Bypass, Kasba, Golpark Kolkata West Bengal IndiaDepartment of Radiation Oncology Ruby General Hospital E.M. Bypass, Kasba, Golpark Kolkata West Bengal IndiaDepartment of Radiation Oncology Ruby General Hospital E.M. Bypass, Kasba, Golpark Kolkata West Bengal IndiaAbstract Objective The aim of this study was to investigate the normal tissue complication probability (NTCP) for parotid gland of ca tongue patients from two different radiobiological models and to establish a dosimetric validity. Methods Lyman–Kutcher–Burman (LKB) model and linear quadratic (LQ) model were considered for determination of NTCP and tolerance dose (TD5/5 and TD50/5) for the parotid gland of 67 number of ca tongue patients who were treated with the volumetric arc therapy (VMAT) technique. An in‐house developed software on Excel (VBA) was used for this study. Results The equivalent uniform dose (EUD) was linearly proportional to the effective volume (veff) for parotid glands and there was a strong correlation between EUD and veff. At EUD = 46 to 47 Gy, the NTCP of parotid was 0.5 for both the models. The tolerance doses, TD5/5 (veff) and TD50/5 (veff) were exponentially reduced with increase of veff for LKB model; whereas these parameters were volume‐independent in the LQ model. TD5/5 (veff) and TD50/5 (veff) were 31.98 Gy and 45.98 Gy respectively for all 67 patients in the LQ model. Below TD50/5, NTCP of LKB model was less than the NTCP , calculated from LQ model. Conclusion One may consider radiobiological LQ model for estimation of clinical tolerance dose for OARs. Due to lack of clinical data, there are inaccuracy in determination of NTCP from LQ model. If sufficient number of tolerance data for partial volumes are available, the prediction of NTCP would be more confident.https://doi.org/10.1002/pro6.1130effective volumeequivalent uniform doseLyman–Kutcher–Burman modelnormal tissue complication probabilityradiobiological model |
| spellingShingle | Srimanta Pramanik Soumen Bera Sanjoy Roy Amitabh Ray Sandip Sarkar Dipanjan Majumder Dosimetric validation of two different radiobiological models for parotid gland functionality of tongue cancer Precision Radiation Oncology effective volume equivalent uniform dose Lyman–Kutcher–Burman model normal tissue complication probability radiobiological model |
| title | Dosimetric validation of two different radiobiological models for parotid gland functionality of tongue cancer |
| title_full | Dosimetric validation of two different radiobiological models for parotid gland functionality of tongue cancer |
| title_fullStr | Dosimetric validation of two different radiobiological models for parotid gland functionality of tongue cancer |
| title_full_unstemmed | Dosimetric validation of two different radiobiological models for parotid gland functionality of tongue cancer |
| title_short | Dosimetric validation of two different radiobiological models for parotid gland functionality of tongue cancer |
| title_sort | dosimetric validation of two different radiobiological models for parotid gland functionality of tongue cancer |
| topic | effective volume equivalent uniform dose Lyman–Kutcher–Burman model normal tissue complication probability radiobiological model |
| url | https://doi.org/10.1002/pro6.1130 |
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