The different roles of innate immune receptors in inflammation and carcinogenesis between races
Abstract Innate immune factors exert widespread effects on cytokine secretion, cell survival, autophagy, and apoptosis. Nucleotide-binding and oligomerization domain-like receptors (NLRs) are members of the innate immune system in the cytosol that sense pathogens, endogenous danger molecules such as...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Komiyama Printing Co. Ltd
2017-10-01
|
| Series: | Environmental Health and Preventive Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12199-017-0678-8 |
| _version_ | 1818175689311911936 |
|---|---|
| author | Natsu Yamaguchi Yoshimi Suzuki M. H. Mahbub Hidekazu Takahashi Ryosuke Hase Yasutaka Ishimaru Hiroshi Sunagawa Rie Watanabe Yoshinobu Eishi Tsuyoshi Tanabe |
| author_facet | Natsu Yamaguchi Yoshimi Suzuki M. H. Mahbub Hidekazu Takahashi Ryosuke Hase Yasutaka Ishimaru Hiroshi Sunagawa Rie Watanabe Yoshinobu Eishi Tsuyoshi Tanabe |
| author_sort | Natsu Yamaguchi |
| collection | DOAJ |
| description | Abstract Innate immune factors exert widespread effects on cytokine secretion, cell survival, autophagy, and apoptosis. Nucleotide-binding and oligomerization domain-like receptors (NLRs) are members of the innate immune system in the cytosol that sense pathogens, endogenous danger molecules such as uric acid, and pollutants. Nucleotide-binding oligomerization domain-containing protein 1 and 2 (NOD1 and NOD2) are components of NLR family, and ligands of these factors are γ-d-glutamyl-meso-diaminopimelic acid (iE-DAP) and muramyl dipeptide (MDP), respectively. Upon recognition of ligands, NOD1 and NOD2 induce the production of inflammatory cytokines and transcription factors including interleukin-6 (IL-6) and nuclear factor-κB (NF-κB). We examined the function of NOD1 and NOD2 in innate immunity, with a focus on their differing roles in disease pathogenesis between Japanese and Caucasian populations. Susceptibility to several immune-related diseases, including Crohn’s disease, colorectal and breast cancers, and graft-versus-host-disease (GVHD) showed a correlation with genetic variants of NOD2 in Caucasian, but not in Japanese, populations. This difference may be primarily due to the fact that three major NOD2 SNPs (R702W, G908R, L1007insC) prevalent in Caucasians are rare or absent in Japanese populations. Because NLR has diverse effects on immune function, it is possible that many as yet uncharacterized immune-related diseases will also show different susceptibilities between races due to the different ratio of genetic variants in innate immune genes. |
| first_indexed | 2024-12-11T20:04:17Z |
| format | Article |
| id | doaj.art-206df4675842498f9d693591a43ee7b5 |
| institution | Directory Open Access Journal |
| issn | 1342-078X 1347-4715 |
| language | English |
| last_indexed | 2024-12-11T20:04:17Z |
| publishDate | 2017-10-01 |
| publisher | Komiyama Printing Co. Ltd |
| record_format | Article |
| series | Environmental Health and Preventive Medicine |
| spelling | doaj.art-206df4675842498f9d693591a43ee7b52022-12-22T00:52:26ZengKomiyama Printing Co. LtdEnvironmental Health and Preventive Medicine1342-078X1347-47152017-10-012211510.1186/s12199-017-0678-8The different roles of innate immune receptors in inflammation and carcinogenesis between racesNatsu Yamaguchi0Yoshimi Suzuki1M. H. Mahbub2Hidekazu Takahashi3Ryosuke Hase4Yasutaka Ishimaru5Hiroshi Sunagawa6Rie Watanabe7Yoshinobu Eishi8Tsuyoshi Tanabe9Department of Public Health and Preventive Medicine, Graduate School of Medicine, Yamaguchi UniversityDepartment of Human Pathology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental UniversityDepartment of Public Health and Preventive Medicine, Graduate School of Medicine, Yamaguchi UniversityDepartment of Public Health and Preventive Medicine, Graduate School of Medicine, Yamaguchi UniversityDepartment of Public Health and Preventive Medicine, Graduate School of Medicine, Yamaguchi UniversityDepartment of Public Health and Preventive Medicine, Graduate School of Medicine, Yamaguchi UniversityDepartment of Public Health and Preventive Medicine, Graduate School of Medicine, Yamaguchi UniversityDepartment of Public Health and Preventive Medicine, Graduate School of Medicine, Yamaguchi UniversityDepartment of Human Pathology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental UniversityDepartment of Public Health and Preventive Medicine, Graduate School of Medicine, Yamaguchi UniversityAbstract Innate immune factors exert widespread effects on cytokine secretion, cell survival, autophagy, and apoptosis. Nucleotide-binding and oligomerization domain-like receptors (NLRs) are members of the innate immune system in the cytosol that sense pathogens, endogenous danger molecules such as uric acid, and pollutants. Nucleotide-binding oligomerization domain-containing protein 1 and 2 (NOD1 and NOD2) are components of NLR family, and ligands of these factors are γ-d-glutamyl-meso-diaminopimelic acid (iE-DAP) and muramyl dipeptide (MDP), respectively. Upon recognition of ligands, NOD1 and NOD2 induce the production of inflammatory cytokines and transcription factors including interleukin-6 (IL-6) and nuclear factor-κB (NF-κB). We examined the function of NOD1 and NOD2 in innate immunity, with a focus on their differing roles in disease pathogenesis between Japanese and Caucasian populations. Susceptibility to several immune-related diseases, including Crohn’s disease, colorectal and breast cancers, and graft-versus-host-disease (GVHD) showed a correlation with genetic variants of NOD2 in Caucasian, but not in Japanese, populations. This difference may be primarily due to the fact that three major NOD2 SNPs (R702W, G908R, L1007insC) prevalent in Caucasians are rare or absent in Japanese populations. Because NLR has diverse effects on immune function, it is possible that many as yet uncharacterized immune-related diseases will also show different susceptibilities between races due to the different ratio of genetic variants in innate immune genes.http://link.springer.com/article/10.1186/s12199-017-0678-8TLRNODCrohn’s diseaseSarcoidosis |
| spellingShingle | Natsu Yamaguchi Yoshimi Suzuki M. H. Mahbub Hidekazu Takahashi Ryosuke Hase Yasutaka Ishimaru Hiroshi Sunagawa Rie Watanabe Yoshinobu Eishi Tsuyoshi Tanabe The different roles of innate immune receptors in inflammation and carcinogenesis between races Environmental Health and Preventive Medicine TLR NOD Crohn’s disease Sarcoidosis |
| title | The different roles of innate immune receptors in inflammation and carcinogenesis between races |
| title_full | The different roles of innate immune receptors in inflammation and carcinogenesis between races |
| title_fullStr | The different roles of innate immune receptors in inflammation and carcinogenesis between races |
| title_full_unstemmed | The different roles of innate immune receptors in inflammation and carcinogenesis between races |
| title_short | The different roles of innate immune receptors in inflammation and carcinogenesis between races |
| title_sort | different roles of innate immune receptors in inflammation and carcinogenesis between races |
| topic | TLR NOD Crohn’s disease Sarcoidosis |
| url | http://link.springer.com/article/10.1186/s12199-017-0678-8 |
| work_keys_str_mv | AT natsuyamaguchi thedifferentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT yoshimisuzuki thedifferentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT mhmahbub thedifferentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT hidekazutakahashi thedifferentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT ryosukehase thedifferentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT yasutakaishimaru thedifferentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT hiroshisunagawa thedifferentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT riewatanabe thedifferentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT yoshinobueishi thedifferentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT tsuyoshitanabe thedifferentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT natsuyamaguchi differentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT yoshimisuzuki differentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT mhmahbub differentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT hidekazutakahashi differentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT ryosukehase differentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT yasutakaishimaru differentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT hiroshisunagawa differentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT riewatanabe differentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT yoshinobueishi differentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces AT tsuyoshitanabe differentrolesofinnateimmunereceptorsininflammationandcarcinogenesisbetweenraces |