mtDNA-STING Axis Mediates Microglial Polarization via IRF3/NF-κB Signaling After Ischemic Stroke

mtDNA-STING Axis Mediates Microglial Polarization via IRF3/NF-κB Signaling After Ischemic Stroke

Neuroinflammation is initiated in response to ischemic stroke, and is usually characterized by microglial activation and polarization. Stimulator of interferon genes (STING) has been shown to play a critical role in anti-tumor immunity and inflammatory diseases. Nevertheless, the effect and underlyi...

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Bibliographic Details
Main Authors: Lingqi Kong, Wenyu Li, E Chang, Wuxuan Wang, Nan Shen, Xiang Xu, Xinyue Wang, Yan Zhang, Wen Sun, Wei Hu, Pengfei Xu, Xinfeng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
ischemia/reperfusion (I/R) injury
STING
microglia
polarization
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.860977/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.860977/full

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