The Clinical Characteristics and Prognosis of Different Age Patients with Lung Cancer
Xiaorao Chen,1,* Xiaoling Han,2,* Honglian Zhou,3,* Yahai Liang,1 Zhong Huang,1 Shujun Li,1 Yanming Lin,1 Xiaobi Huang,1 Jiancong Wu,1 Wenmei Su,1 Zhennan Lai,1 Zhixiong Yang1 1Department of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, People’s...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-09-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-clinical-characteristics-and-prognosis-of-different-age-patients-w-peer-reviewed-article-CMAR |
| _version_ | 1830518032348217344 |
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| author | Chen X Han X Zhou H Liang Y Huang Z Li S Lin Y Huang X Wu J Su W Lai Z Yang Z |
| author_facet | Chen X Han X Zhou H Liang Y Huang Z Li S Lin Y Huang X Wu J Su W Lai Z Yang Z |
| author_sort | Chen X |
| collection | DOAJ |
| description | Xiaorao Chen,1,* Xiaoling Han,2,* Honglian Zhou,3,* Yahai Liang,1 Zhong Huang,1 Shujun Li,1 Yanming Lin,1 Xiaobi Huang,1 Jiancong Wu,1 Wenmei Su,1 Zhennan Lai,1 Zhixiong Yang1 1Department of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, People’s Republic of China; 2Guangdong Medical University, Zhanjiang 524001, People’s Republic of China; 3Department of Ultrasound, Guangdong Medical University Affiliated Hospital, Zhanjiang 524001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhixiong Yang; Zhennan Lai Tel +8613802822690; +8613822526918Email yangzhixiong068@126.com; laizhenn@163.comObjective: Cancer is closely related to age, and the incidence of cancer increases with age. However, there are few studies on the relationship between age and clinical characteristics of lung cancer.Patients and Methods: We collected all the consecutive lung cancer cases from 2012 to 2017 in our hospital and divided them into 6 groups according to their ages: ≤ 40 y/o, 41∼ 50 y/o, 51∼ 60 y/o, 61∼ 70 y/o, 71∼ 80 y/o and > 80 y/o. The clinical characteristics and prognosis of these patients were evaluated.Results: There were 1143 cases diagnosed in our hospital from 2012 to 2017. There were more non-smokers (p< 0.01), stage IV (p< 0.01) and anaplastic lymphoma kinase (ALK) fusion (p< 0.01) patients but less stage I patients in ≤ 40 y/o group compared with other age groups. It seemed that older patients were more likely had co-exist driver gene mutations (p=0.04). There was no significant difference in overall survival (OS) among these 6 age groups. However, the age may be an independent prognostic factor compared with the patients in ≤ 40 y/o group, the patients in > 80 y/o group were associated with a higher mortality risk, while the patients in other groups had the similar mortality risk.Conclusion: There are some differences in clinical characteristics and prognosis among different age groups. The reasons behind the phenomenon are largely unclear. The age should be taken into account when we develop clinical trials.Keywords: age, lung cancer, clinical characteristics, clinical trials |
| first_indexed | 2024-12-22T04:11:28Z |
| format | Article |
| id | doaj.art-2075ade2626043fcb3d659b5923d8dd8 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-22T04:11:28Z |
| publishDate | 2020-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-2075ade2626043fcb3d659b5923d8dd82022-12-21T18:39:30ZengDove Medical PressCancer Management and Research1179-13222020-09-01Volume 128445845057003The Clinical Characteristics and Prognosis of Different Age Patients with Lung CancerChen XHan XZhou HLiang YHuang ZLi SLin YHuang XWu JSu WLai ZYang ZXiaorao Chen,1,* Xiaoling Han,2,* Honglian Zhou,3,* Yahai Liang,1 Zhong Huang,1 Shujun Li,1 Yanming Lin,1 Xiaobi Huang,1 Jiancong Wu,1 Wenmei Su,1 Zhennan Lai,1 Zhixiong Yang1 1Department of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, People’s Republic of China; 2Guangdong Medical University, Zhanjiang 524001, People’s Republic of China; 3Department of Ultrasound, Guangdong Medical University Affiliated Hospital, Zhanjiang 524001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhixiong Yang; Zhennan Lai Tel +8613802822690; +8613822526918Email yangzhixiong068@126.com; laizhenn@163.comObjective: Cancer is closely related to age, and the incidence of cancer increases with age. However, there are few studies on the relationship between age and clinical characteristics of lung cancer.Patients and Methods: We collected all the consecutive lung cancer cases from 2012 to 2017 in our hospital and divided them into 6 groups according to their ages: ≤ 40 y/o, 41∼ 50 y/o, 51∼ 60 y/o, 61∼ 70 y/o, 71∼ 80 y/o and > 80 y/o. The clinical characteristics and prognosis of these patients were evaluated.Results: There were 1143 cases diagnosed in our hospital from 2012 to 2017. There were more non-smokers (p< 0.01), stage IV (p< 0.01) and anaplastic lymphoma kinase (ALK) fusion (p< 0.01) patients but less stage I patients in ≤ 40 y/o group compared with other age groups. It seemed that older patients were more likely had co-exist driver gene mutations (p=0.04). There was no significant difference in overall survival (OS) among these 6 age groups. However, the age may be an independent prognostic factor compared with the patients in ≤ 40 y/o group, the patients in > 80 y/o group were associated with a higher mortality risk, while the patients in other groups had the similar mortality risk.Conclusion: There are some differences in clinical characteristics and prognosis among different age groups. The reasons behind the phenomenon are largely unclear. The age should be taken into account when we develop clinical trials.Keywords: age, lung cancer, clinical characteristics, clinical trialshttps://www.dovepress.com/the-clinical-characteristics-and-prognosis-of-different-age-patients-w-peer-reviewed-article-CMARagelung cancerclinical characteristicsclinical trials |
| spellingShingle | Chen X Han X Zhou H Liang Y Huang Z Li S Lin Y Huang X Wu J Su W Lai Z Yang Z The Clinical Characteristics and Prognosis of Different Age Patients with Lung Cancer Cancer Management and Research age lung cancer clinical characteristics clinical trials |
| title | The Clinical Characteristics and Prognosis of Different Age Patients with Lung Cancer |
| title_full | The Clinical Characteristics and Prognosis of Different Age Patients with Lung Cancer |
| title_fullStr | The Clinical Characteristics and Prognosis of Different Age Patients with Lung Cancer |
| title_full_unstemmed | The Clinical Characteristics and Prognosis of Different Age Patients with Lung Cancer |
| title_short | The Clinical Characteristics and Prognosis of Different Age Patients with Lung Cancer |
| title_sort | clinical characteristics and prognosis of different age patients with lung cancer |
| topic | age lung cancer clinical characteristics clinical trials |
| url | https://www.dovepress.com/the-clinical-characteristics-and-prognosis-of-different-age-patients-w-peer-reviewed-article-CMAR |
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