The critical role of neutrophil-endothelial cell interactions in sepsis: new synergistic approaches employing organ-on-chip, omics, immune cell phenotyping and in silico modeling to identify new therapeutics

The critical role of neutrophil-endothelial cell interactions in sepsis: new synergistic approaches employing organ-on-chip, omics, immune cell phenotyping and in silico modeling to identify new therapeutics

Sepsis is a global health concern accounting for more than 1 in 5 deaths worldwide. Sepsis is now defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis can develop from bacterial (gram negative or gram positive), fungal or viral (such as COVID) inf...

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Bibliographic Details
Main Authors: Dan Liu, Jordan C. Langston, Balabhaskar Prabhakarpandian, Mohammad F. Kiani, Laurie E. Kilpatrick
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
biomimetic microfluidic assay
endothelial cells
inflammation
in silico modeling
neutrophils
omics
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1274842/full

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