Contribution of coagulation factor VII R353Q polymorphism to the risk of thrombotic disorders development (venous and arterial): A case-control study
Background: Elevated factor VII (FVII) level is a risk factor for thromboembolic disorders. It was reported that the FVII R353Q polymorphism is associated with variation in plasma FVII levels, where Q allele carriers were more associated with lower levels of FVII than R allele carriers. However, the...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2017-07-01
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| Series: | Egyptian Journal of Medical Human Genetics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110863016300775 |
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| author | Hanan Azzam Reham M. El-Farahaty Nashwa K. Abousamra Hossam Elwakeel Sherif Sakr Ayman Helmy Eman Khashaba |
| author_facet | Hanan Azzam Reham M. El-Farahaty Nashwa K. Abousamra Hossam Elwakeel Sherif Sakr Ayman Helmy Eman Khashaba |
| author_sort | Hanan Azzam |
| collection | DOAJ |
| description | Background: Elevated factor VII (FVII) level is a risk factor for thromboembolic disorders. It was reported that the FVII R353Q polymorphism is associated with variation in plasma FVII levels, where Q allele carriers were more associated with lower levels of FVII than R allele carriers. However, the association between coagulation FVII R353 Q polymorphisms and the risk of thrombosis is uncertain.
Aim of the study: Is to investigate the contribution of factor VII R353Q gene polymorphism to the risk of thrombotic disorders development (venous and arterial) in a group of Egyptian patients.
Subjects and methods: This study was conducted on 310 subjects: 110 acute myocardial infarction (AMI) patients, 108 deep venous thrombosis (DVT) patients and 92 healthy controls. FVII R353Q genotypes were assessed using restriction fragment length polymorphism analysis.
Results: There were no statistically significant differences in the frequency of FVII R353Q polymorphism between each of the AMI and DVT patients and the control group (P = 0.9, 0.1). However the Q allele showed a significantly higher frequency in the AMI group (15.4%) vs. controls (8.7%) (OR: 1.92; 95% CI: 0.98–3.7). Bivariate analysis demonstrated no significant association between FVII R353Q genotypes and different studied risk factors, neither in arterial nor venous thrombosis.
Conclusion: FVII R353Q polymorphism did not contribute to an increased risk of thrombosis (arterial and venous); also carrying the Q allele (of R353Q) did not confer protection against acute thrombotic events. |
| first_indexed | 2024-12-10T08:50:16Z |
| format | Article |
| id | doaj.art-2078825a37174dc79629a5e3c976dde2 |
| institution | Directory Open Access Journal |
| issn | 1110-8630 |
| language | English |
| last_indexed | 2024-12-10T08:50:16Z |
| publishDate | 2017-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Medical Human Genetics |
| spelling | doaj.art-2078825a37174dc79629a5e3c976dde22022-12-22T01:55:36ZengSpringerOpenEgyptian Journal of Medical Human Genetics1110-86302017-07-0118327527910.1016/j.ejmhg.2016.11.002Contribution of coagulation factor VII R353Q polymorphism to the risk of thrombotic disorders development (venous and arterial): A case-control studyHanan Azzam0Reham M. El-Farahaty1Nashwa K. Abousamra2Hossam Elwakeel3Sherif Sakr4Ayman Helmy5Eman Khashaba6Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, EgyptDepartment of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, EgyptDepartment of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, EgyptDepartment of Vascular Surgery, Faculty of Medicine, Mansoura University, Mansoura, EgyptDepartment of Cardiology, Faculty of Medicine, Mansoura University, Mansoura, EgyptDepartment of Cardiology, Faculty of Medicine, Mansoura University, Mansoura, EgyptDepartment of Public Health & Community Medicine, Faculty of Medicine, Mansoura University, Mansoura, EgyptBackground: Elevated factor VII (FVII) level is a risk factor for thromboembolic disorders. It was reported that the FVII R353Q polymorphism is associated with variation in plasma FVII levels, where Q allele carriers were more associated with lower levels of FVII than R allele carriers. However, the association between coagulation FVII R353 Q polymorphisms and the risk of thrombosis is uncertain. Aim of the study: Is to investigate the contribution of factor VII R353Q gene polymorphism to the risk of thrombotic disorders development (venous and arterial) in a group of Egyptian patients. Subjects and methods: This study was conducted on 310 subjects: 110 acute myocardial infarction (AMI) patients, 108 deep venous thrombosis (DVT) patients and 92 healthy controls. FVII R353Q genotypes were assessed using restriction fragment length polymorphism analysis. Results: There were no statistically significant differences in the frequency of FVII R353Q polymorphism between each of the AMI and DVT patients and the control group (P = 0.9, 0.1). However the Q allele showed a significantly higher frequency in the AMI group (15.4%) vs. controls (8.7%) (OR: 1.92; 95% CI: 0.98–3.7). Bivariate analysis demonstrated no significant association between FVII R353Q genotypes and different studied risk factors, neither in arterial nor venous thrombosis. Conclusion: FVII R353Q polymorphism did not contribute to an increased risk of thrombosis (arterial and venous); also carrying the Q allele (of R353Q) did not confer protection against acute thrombotic events.http://www.sciencedirect.com/science/article/pii/S1110863016300775AMIDVTFVII R353Q polymorphismThrombo-embolic risk |
| spellingShingle | Hanan Azzam Reham M. El-Farahaty Nashwa K. Abousamra Hossam Elwakeel Sherif Sakr Ayman Helmy Eman Khashaba Contribution of coagulation factor VII R353Q polymorphism to the risk of thrombotic disorders development (venous and arterial): A case-control study Egyptian Journal of Medical Human Genetics AMI DVT FVII R353Q polymorphism Thrombo-embolic risk |
| title | Contribution of coagulation factor VII R353Q polymorphism to the risk of thrombotic disorders development (venous and arterial): A case-control study |
| title_full | Contribution of coagulation factor VII R353Q polymorphism to the risk of thrombotic disorders development (venous and arterial): A case-control study |
| title_fullStr | Contribution of coagulation factor VII R353Q polymorphism to the risk of thrombotic disorders development (venous and arterial): A case-control study |
| title_full_unstemmed | Contribution of coagulation factor VII R353Q polymorphism to the risk of thrombotic disorders development (venous and arterial): A case-control study |
| title_short | Contribution of coagulation factor VII R353Q polymorphism to the risk of thrombotic disorders development (venous and arterial): A case-control study |
| title_sort | contribution of coagulation factor vii r353q polymorphism to the risk of thrombotic disorders development venous and arterial a case control study |
| topic | AMI DVT FVII R353Q polymorphism Thrombo-embolic risk |
| url | http://www.sciencedirect.com/science/article/pii/S1110863016300775 |
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