Structural and dynamical effects induced by the anticancer drug topotecan on the human topoisomerase I - DNA complex.

Structural and dynamical effects induced by the anticancer drug topotecan on the human topoisomerase I - DNA complex.

BACKGROUND: Human topoisomerase I catalyzes the relaxation of DNA supercoils in fundamental cell processes like transcription, replication and chromosomal segregation. It is the only target of the camptothecin family of anticancer drugs. Among these, topotecan has been used to treat lung and ovarian...

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Bibliographic Details
Main Authors: Giordano Mancini, Ilda D'Annessa, Andrea Coletta, Nico Sanna, Giovanni Chillemi, Alessandro Desideri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2880615?pdf=render

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