The Role of Platelet and its Interaction with Aspirin
Introduction. Platelets are not strictly “cells”, they are cytoplasmic fragments that are produced by the division of the cytoplasm of the megakaryocytes in the bone marrow; among its properties of adhesion and aggregation, platelets are involved in primary hemostasis, thrombosis, repair and tissue...
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| Format: | Article |
| Language: | English |
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Universidad Nacional de Colombia
2016-04-01
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| Series: | Revista de la Facultad de Medicina |
| Online Access: | https://revistas.unal.edu.co/index.php/revfacmed/article/view/53789 |
| _version_ | 1828170722667659264 |
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| author | Luisa Fernanda Zúñiga Cerón Jann Sebastián Saavedra Torres Carlos Alberto Navia Amézquita |
| author_facet | Luisa Fernanda Zúñiga Cerón Jann Sebastián Saavedra Torres Carlos Alberto Navia Amézquita |
| author_sort | Luisa Fernanda Zúñiga Cerón |
| collection | DOAJ |
| description | Introduction. Platelets are not strictly “cells”, they are cytoplasmic fragments that are produced by the division of the cytoplasm of the megakaryocytes in the bone marrow; among its properties of adhesion and aggregation, platelets are involved in primary hemostasis, thrombosis, repair and tissue regeneration processes. To modify the pro-thrombotic platelet properties aspirin (ASA) is provided, which allows blocking the synthesis of prostaglandins in order to irreversibly inhibit the COX1 and prevent platelet aggregation. The current guidelines govern the use of aspirin in the prevention of cardiovascular diseases.
Objective. In this review paper graphics were created to facilitate the understanding of platelets and its interaction with various physiological and pathological processes.
Methodology. A literature review of a total of 74 documents such as articles and books was carried out; it was obtained from bibliographic searches in the following databases: Scielo, NEJM, Elsevier, Pubmed, Redalyc, Wiley, Springer, ScienceDirect, BVS, Nature Riviews, EBSCO, Naxos (databases offered by the University of Cauca). Mendeley free access program was used for the management and organization of information.
Conclusion. It is recognized the role of platelet in different physiopathological processes and thus its interaction with aspirin, preventing its aggregation and thrombus formation in the spleen and other organs, this way contributing to the prevention of future cardiovascular events. |
| first_indexed | 2024-04-12T03:15:03Z |
| format | Article |
| id | doaj.art-207affdf67d74e4788aec6ab85215c5f |
| institution | Directory Open Access Journal |
| issn | 0120-0011 2357-3848 |
| language | English |
| last_indexed | 2024-04-12T03:15:03Z |
| publishDate | 2016-04-01 |
| publisher | Universidad Nacional de Colombia |
| record_format | Article |
| series | Revista de la Facultad de Medicina |
| spelling | doaj.art-207affdf67d74e4788aec6ab85215c5f2022-12-22T03:50:10ZengUniversidad Nacional de ColombiaRevista de la Facultad de Medicina0120-00112357-38482016-04-0164235136310.15446/revfacmed.v64n2.5378943543The Role of Platelet and its Interaction with AspirinLuisa Fernanda Zúñiga CerónJann Sebastián Saavedra TorresCarlos Alberto Navia AmézquitaIntroduction. Platelets are not strictly “cells”, they are cytoplasmic fragments that are produced by the division of the cytoplasm of the megakaryocytes in the bone marrow; among its properties of adhesion and aggregation, platelets are involved in primary hemostasis, thrombosis, repair and tissue regeneration processes. To modify the pro-thrombotic platelet properties aspirin (ASA) is provided, which allows blocking the synthesis of prostaglandins in order to irreversibly inhibit the COX1 and prevent platelet aggregation. The current guidelines govern the use of aspirin in the prevention of cardiovascular diseases. Objective. In this review paper graphics were created to facilitate the understanding of platelets and its interaction with various physiological and pathological processes. Methodology. A literature review of a total of 74 documents such as articles and books was carried out; it was obtained from bibliographic searches in the following databases: Scielo, NEJM, Elsevier, Pubmed, Redalyc, Wiley, Springer, ScienceDirect, BVS, Nature Riviews, EBSCO, Naxos (databases offered by the University of Cauca). Mendeley free access program was used for the management and organization of information. Conclusion. It is recognized the role of platelet in different physiopathological processes and thus its interaction with aspirin, preventing its aggregation and thrombus formation in the spleen and other organs, this way contributing to the prevention of future cardiovascular events.https://revistas.unal.edu.co/index.php/revfacmed/article/view/53789 |
| spellingShingle | Luisa Fernanda Zúñiga Cerón Jann Sebastián Saavedra Torres Carlos Alberto Navia Amézquita The Role of Platelet and its Interaction with Aspirin Revista de la Facultad de Medicina |
| title | The Role of Platelet and its Interaction with Aspirin |
| title_full | The Role of Platelet and its Interaction with Aspirin |
| title_fullStr | The Role of Platelet and its Interaction with Aspirin |
| title_full_unstemmed | The Role of Platelet and its Interaction with Aspirin |
| title_short | The Role of Platelet and its Interaction with Aspirin |
| title_sort | role of platelet and its interaction with aspirin |
| url | https://revistas.unal.edu.co/index.php/revfacmed/article/view/53789 |
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