Relationship between Antenatal Maternal Neutrophil-to-Lymphocyte Ratio and Early Onset Neonatal Sepsis in Preterm Neonates
Objectives: To determine the relationship between maternal neutrophil to lymphocyte ratio (NLR) and early onset neonatal sepsis (EONS) in preterm neonates.Materials and Methods: Between 2012 to 2016, a total of 485 cases of preterm delivery were retrospectively reviewed. Study...
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| Format: | Article |
| Language: | English |
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The Royal Thai College of Obstetricians and Gynaecologists
2020-04-01
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| Series: | Thai Journal of Obstetrics and Gynaecology |
| Subjects: | |
| Online Access: | https://he02.tci-thaijo.org/index.php/tjog/article/download/148098/163939/ |
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| author | Thitiphan Chayawongrungreung Jiraporn Luengmettakul Aungsumalin Srilar |
| author_facet | Thitiphan Chayawongrungreung Jiraporn Luengmettakul Aungsumalin Srilar |
| author_sort | Thitiphan Chayawongrungreung |
| collection | DOAJ |
| description | Objectives: To determine the relationship between maternal neutrophil to lymphocyte ratio (NLR) and early onset neonatal sepsis (EONS) in preterm neonates.Materials and Methods: Between 2012 to 2016, a total of 485 cases of preterm delivery were retrospectively reviewed. Study group consisted of 97 neonates diagnosed with EONS and other 388 without EONS were randomly selected as a comparison group (1:4 ratio). Data were extracted from medical records, including baseline characteristics, obstetric and delivery data. Maternal NLR was calculated from laboratory results within 72 hours prior to delivery. Results: Neonates with EONS were significantly more likely to deliver at < 34 weeks (p < 0.001), had preterm premature rupture of membranes (p = 0.043), and had maternal fever (p = 0.016). White blood cell and neutrophil counts were significantly higher in EONS group while lymphocyte counts were comparable. Median NLR was significantly higher in EONS group (4.7 vs. 4.1, p = 0.005). NLR of > 5 significantly increased the risk of EONS (26.8% vs. 16.4%, p = 0.007). Logistic regression analysis showed that delivery at < 34 weeks and maternal fever were independently associated with EONS (adjusted odds ratio (ORs) 11.5, 95% confidence interval (CI) 6.7-19.7, and 3.4, 95% CI 1.1-11.3, respectively). Subgroup analysis showed that NLR of ≥ 5 independently increased the risk of EONS in those delivered at < 34 weeks (adjusted ORs 3.5, 95% CI 1.4-9.1) and maternal fever independently increased the risk of EONS in those delivered at ≥ 34 weeks (adjusted ORs 6.1, 95% CI 1.8-20.3).Conclusion: Maternal NLR was significantly associated with EONS in preterm neonates, especially those delivered at < 34 weeks. |
| first_indexed | 2024-12-10T21:01:23Z |
| format | Article |
| id | doaj.art-20819eaefeca40cbbe7a3a567cfbb86b |
| institution | Directory Open Access Journal |
| issn | 0857-6084 |
| language | English |
| last_indexed | 2024-12-10T21:01:23Z |
| publishDate | 2020-04-01 |
| publisher | The Royal Thai College of Obstetricians and Gynaecologists |
| record_format | Article |
| series | Thai Journal of Obstetrics and Gynaecology |
| spelling | doaj.art-20819eaefeca40cbbe7a3a567cfbb86b2022-12-22T01:33:47ZengThe Royal Thai College of Obstetricians and GynaecologistsThai Journal of Obstetrics and Gynaecology0857-60842020-04-0128294102https://doi.org/10.14456/tjog.2020.13Relationship between Antenatal Maternal Neutrophil-to-Lymphocyte Ratio and Early Onset Neonatal Sepsis in Preterm NeonatesThitiphan Chayawongrungreung0Jiraporn Luengmettakul1Aungsumalin Srilar2Department of Obstetrics and Gynecology, Chareonkrung Pracharak Hospital, Medical Service Department, Bangkok Metropolitan Administration, Bangkok, ThailandDepartment of Obstetrics and Gynecology, Chareonkrung Pracharak Hospital, Medical Service Department, Bangkok Metropolitan Administration, Bangkok, ThailandDepartment of Obstetrics and Gynecology, Chareonkrung Pracharak Hospital, Medical Service Department, Bangkok Metropolitan Administration, Bangkok, ThailandObjectives: To determine the relationship between maternal neutrophil to lymphocyte ratio (NLR) and early onset neonatal sepsis (EONS) in preterm neonates.Materials and Methods: Between 2012 to 2016, a total of 485 cases of preterm delivery were retrospectively reviewed. Study group consisted of 97 neonates diagnosed with EONS and other 388 without EONS were randomly selected as a comparison group (1:4 ratio). Data were extracted from medical records, including baseline characteristics, obstetric and delivery data. Maternal NLR was calculated from laboratory results within 72 hours prior to delivery. Results: Neonates with EONS were significantly more likely to deliver at < 34 weeks (p < 0.001), had preterm premature rupture of membranes (p = 0.043), and had maternal fever (p = 0.016). White blood cell and neutrophil counts were significantly higher in EONS group while lymphocyte counts were comparable. Median NLR was significantly higher in EONS group (4.7 vs. 4.1, p = 0.005). NLR of > 5 significantly increased the risk of EONS (26.8% vs. 16.4%, p = 0.007). Logistic regression analysis showed that delivery at < 34 weeks and maternal fever were independently associated with EONS (adjusted odds ratio (ORs) 11.5, 95% confidence interval (CI) 6.7-19.7, and 3.4, 95% CI 1.1-11.3, respectively). Subgroup analysis showed that NLR of ≥ 5 independently increased the risk of EONS in those delivered at < 34 weeks (adjusted ORs 3.5, 95% CI 1.4-9.1) and maternal fever independently increased the risk of EONS in those delivered at ≥ 34 weeks (adjusted ORs 6.1, 95% CI 1.8-20.3).Conclusion: Maternal NLR was significantly associated with EONS in preterm neonates, especially those delivered at < 34 weeks.https://he02.tci-thaijo.org/index.php/tjog/article/download/148098/163939/preterm neonatesearly onset neonatal sepsisneutrophil to lymphocyte ratio |
| spellingShingle | Thitiphan Chayawongrungreung Jiraporn Luengmettakul Aungsumalin Srilar Relationship between Antenatal Maternal Neutrophil-to-Lymphocyte Ratio and Early Onset Neonatal Sepsis in Preterm Neonates Thai Journal of Obstetrics and Gynaecology preterm neonates early onset neonatal sepsis neutrophil to lymphocyte ratio |
| title | Relationship between Antenatal Maternal Neutrophil-to-Lymphocyte Ratio and Early Onset Neonatal Sepsis in Preterm Neonates |
| title_full | Relationship between Antenatal Maternal Neutrophil-to-Lymphocyte Ratio and Early Onset Neonatal Sepsis in Preterm Neonates |
| title_fullStr | Relationship between Antenatal Maternal Neutrophil-to-Lymphocyte Ratio and Early Onset Neonatal Sepsis in Preterm Neonates |
| title_full_unstemmed | Relationship between Antenatal Maternal Neutrophil-to-Lymphocyte Ratio and Early Onset Neonatal Sepsis in Preterm Neonates |
| title_short | Relationship between Antenatal Maternal Neutrophil-to-Lymphocyte Ratio and Early Onset Neonatal Sepsis in Preterm Neonates |
| title_sort | relationship between antenatal maternal neutrophil to lymphocyte ratio and early onset neonatal sepsis in preterm neonates |
| topic | preterm neonates early onset neonatal sepsis neutrophil to lymphocyte ratio |
| url | https://he02.tci-thaijo.org/index.php/tjog/article/download/148098/163939/ |
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