A 20-year retrospective study of osteoarticular tuberculosis in a pediatric third level referral center
Abstract Purpose The objective of the present study is to describe the clinical, diagnostic, radiological and therapeutic aspects of osteoarticular tuberculosis (OATB) in patients in a tertiary pediatric hospital, to know if the diagnosis of OATB in pediatrics is a challenge due to its insidious cli...
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-021-01631-2 |
| _version_ | 1831746104462409728 |
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| author | Napoleón González Saldaña Mercedes Macías Parra Luis Xochihua Díaz Martin Palavicini Rueda Ana Jocelyn Carmona Vargas José Iván Castillo Bejarano Quetzalli Veloz Corona Hugo Juárez Olguín Juan Luis Chavez Pacheco |
| author_facet | Napoleón González Saldaña Mercedes Macías Parra Luis Xochihua Díaz Martin Palavicini Rueda Ana Jocelyn Carmona Vargas José Iván Castillo Bejarano Quetzalli Veloz Corona Hugo Juárez Olguín Juan Luis Chavez Pacheco |
| author_sort | Napoleón González Saldaña |
| collection | DOAJ |
| description | Abstract Purpose The objective of the present study is to describe the clinical, diagnostic, radiological and therapeutic aspects of osteoarticular tuberculosis (OATB) in patients in a tertiary pediatric hospital, to know if the diagnosis of OATB in pediatrics is a challenge due to its insidious clinical presentation. Methods A retrospective, descriptive study of the cases of Tuberculosis (TB) in children was carried out. A total of 159 cases met the condition for the analysis. Results The most frequent TB modality was extrapulmonary in 85%. Out of this, only 29% was OATB. The mean age was 4.9 years (range 8 months–16 years). Eighty-six per cent of cases received Bacille Calmette-Guérin (BCG) vaccination at birth. Median time of symptoms prior to diagnosis was 8 months. Microbiological confirmation was achieved only in five cases, with a high sensitivity to the antimicrobial treatment. Mycobacterium bovis BCG strain Tokio 172 was confirmed in three cases. Mortality rate was 0% during the time of study Conclusion Our study describes the epidemiological characteristics of OATB cases in Mexican children. This data revealed a high prevalence of bone and joint TB infection. Pediatric OATB should be considered in cases with lytic bone lesions, fever and local pain. In countries with BCG immunization program, M. bovis should not be forgotten as an etiological agent. The low detection rate with one technique approach highlights the urgent need for more sensitive test to diagnose OATB in children. |
| first_indexed | 2024-12-21T21:07:59Z |
| format | Article |
| id | doaj.art-2081a826baf8455ab196f6802e397e78 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-21T21:07:59Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-2081a826baf8455ab196f6802e397e782022-12-21T18:50:13ZengBMCBMC Pulmonary Medicine1471-24662021-08-012111610.1186/s12890-021-01631-2A 20-year retrospective study of osteoarticular tuberculosis in a pediatric third level referral centerNapoleón González Saldaña0Mercedes Macías Parra1Luis Xochihua Díaz2Martin Palavicini Rueda3Ana Jocelyn Carmona Vargas4José Iván Castillo Bejarano5Quetzalli Veloz Corona6Hugo Juárez Olguín7Juan Luis Chavez Pacheco8Department of Infectious Diseases, Instituto Nacional de Pediatria (INP)Medical Director, Instituto Nacional de PediatriaDepartment of Infectious Diseases, Instituto Nacional de Pediatria (INP)Department of Traumatology and Orthopedics, INPDepartment of Infectious Diseases, Instituto Nacional de Pediatria (INP)Department of Infectious Diseases, Instituto Nacional de Pediatria (INP)Laboratorio de Farmacología, Instituto Nacional de PediatríaLaboratorio de Farmacología, Instituto Nacional de PediatríaLaboratorio de Farmacología, Instituto Nacional de PediatríaAbstract Purpose The objective of the present study is to describe the clinical, diagnostic, radiological and therapeutic aspects of osteoarticular tuberculosis (OATB) in patients in a tertiary pediatric hospital, to know if the diagnosis of OATB in pediatrics is a challenge due to its insidious clinical presentation. Methods A retrospective, descriptive study of the cases of Tuberculosis (TB) in children was carried out. A total of 159 cases met the condition for the analysis. Results The most frequent TB modality was extrapulmonary in 85%. Out of this, only 29% was OATB. The mean age was 4.9 years (range 8 months–16 years). Eighty-six per cent of cases received Bacille Calmette-Guérin (BCG) vaccination at birth. Median time of symptoms prior to diagnosis was 8 months. Microbiological confirmation was achieved only in five cases, with a high sensitivity to the antimicrobial treatment. Mycobacterium bovis BCG strain Tokio 172 was confirmed in three cases. Mortality rate was 0% during the time of study Conclusion Our study describes the epidemiological characteristics of OATB cases in Mexican children. This data revealed a high prevalence of bone and joint TB infection. Pediatric OATB should be considered in cases with lytic bone lesions, fever and local pain. In countries with BCG immunization program, M. bovis should not be forgotten as an etiological agent. The low detection rate with one technique approach highlights the urgent need for more sensitive test to diagnose OATB in children.https://doi.org/10.1186/s12890-021-01631-2ChildrenDiagnosis of tuberculosisEpidemiologyOsteoarticular tuberculosis |
| spellingShingle | Napoleón González Saldaña Mercedes Macías Parra Luis Xochihua Díaz Martin Palavicini Rueda Ana Jocelyn Carmona Vargas José Iván Castillo Bejarano Quetzalli Veloz Corona Hugo Juárez Olguín Juan Luis Chavez Pacheco A 20-year retrospective study of osteoarticular tuberculosis in a pediatric third level referral center BMC Pulmonary Medicine Children Diagnosis of tuberculosis Epidemiology Osteoarticular tuberculosis |
| title | A 20-year retrospective study of osteoarticular tuberculosis in a pediatric third level referral center |
| title_full | A 20-year retrospective study of osteoarticular tuberculosis in a pediatric third level referral center |
| title_fullStr | A 20-year retrospective study of osteoarticular tuberculosis in a pediatric third level referral center |
| title_full_unstemmed | A 20-year retrospective study of osteoarticular tuberculosis in a pediatric third level referral center |
| title_short | A 20-year retrospective study of osteoarticular tuberculosis in a pediatric third level referral center |
| title_sort | 20 year retrospective study of osteoarticular tuberculosis in a pediatric third level referral center |
| topic | Children Diagnosis of tuberculosis Epidemiology Osteoarticular tuberculosis |
| url | https://doi.org/10.1186/s12890-021-01631-2 |
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