Choice reaction time and subsequent mobility decline: Prospective observational findings from The Irish Longitudinal Study on Ageing (TILDA)
Background: Cognitive and motor function in ageing are intertwined, but whether slower motor response time (MRT) to a cognitive stimulus could herald accelerated mobility decline is unknown. Using data from The Irish Longitudinal Study on Ageing (TILDA), we examined whether slower MRT may predict a...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-01-01
|
| Series: | EClinicalMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258953702030420X |
| _version_ | 1818643005238673408 |
|---|---|
| author | Renuka Chintapalli Roman Romero-Ortuno |
| author_facet | Renuka Chintapalli Roman Romero-Ortuno |
| author_sort | Renuka Chintapalli |
| collection | DOAJ |
| description | Background: Cognitive and motor function in ageing are intertwined, but whether slower motor response time (MRT) to a cognitive stimulus could herald accelerated mobility decline is unknown. Using data from The Irish Longitudinal Study on Ageing (TILDA), we examined whether slower MRT may predict a greater than expected increase in Time Up and Go (TUG) after 4 years. Methods: Participants aged 50 years or older were divided into two groups based on their mean MRT (< 250 ms versus ≥ 250 ms). A repeated measures ANOVA compared TUG trajectories between groups, controlling for baseline age, sex, height, education level, mini mental-state examination (MMSE) score, self-reported vision and hearing, medical conditions (cardiovascular, cerebrovascular disease, diabetes), and number of medications. Findings: At Wave 1, 1982 (58.7%) had a mean MRT of < 250 ms, with a mean TUG of 8.1 s (SD 1.6); and 1397 (41.3%) had an MRT of ≥ 250 ms, with a TUG of 9.0 s (SD 2.2). At Wave 3, TUG increased to 8.8 s (SD 2.0) and 10.2 s (SD 3.9), respectively. The results of the adjusted repeated measures ANOVA suggested that there was a statistically significant interaction between MRT group and Wave (P = 0.023, η2p = 0.002). Interpretation: TILDA participants in the slower MRT group seemed to have faster mobility decline, but this effect was statistically and clinically small. Funding: TILDA is funded by Atlantic Philanthropies, the Irish Department of Health and Irish Life. Roman Romero-Ortuno is funded by Science Foundation Ireland (grant number 18/FRL/6188). |
| first_indexed | 2024-12-16T23:52:04Z |
| format | Article |
| id | doaj.art-208461250c3845ae850efb3137138d61 |
| institution | Directory Open Access Journal |
| issn | 2589-5370 |
| language | English |
| last_indexed | 2024-12-16T23:52:04Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj.art-208461250c3845ae850efb3137138d612022-12-21T22:11:18ZengElsevierEClinicalMedicine2589-53702021-01-0131100676Choice reaction time and subsequent mobility decline: Prospective observational findings from The Irish Longitudinal Study on Ageing (TILDA)Renuka Chintapalli0Roman Romero-Ortuno1Department of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom; Corresponding author.Discipline of Medical Gerontology, School of Medicine, Trinity College Dublin, Ireland; The Irish Longitudinal Study on Ageing, Trinity College Dublin, Ireland; Global Brain Health Institute, Trinity College Dublin, IrelandBackground: Cognitive and motor function in ageing are intertwined, but whether slower motor response time (MRT) to a cognitive stimulus could herald accelerated mobility decline is unknown. Using data from The Irish Longitudinal Study on Ageing (TILDA), we examined whether slower MRT may predict a greater than expected increase in Time Up and Go (TUG) after 4 years. Methods: Participants aged 50 years or older were divided into two groups based on their mean MRT (< 250 ms versus ≥ 250 ms). A repeated measures ANOVA compared TUG trajectories between groups, controlling for baseline age, sex, height, education level, mini mental-state examination (MMSE) score, self-reported vision and hearing, medical conditions (cardiovascular, cerebrovascular disease, diabetes), and number of medications. Findings: At Wave 1, 1982 (58.7%) had a mean MRT of < 250 ms, with a mean TUG of 8.1 s (SD 1.6); and 1397 (41.3%) had an MRT of ≥ 250 ms, with a TUG of 9.0 s (SD 2.2). At Wave 3, TUG increased to 8.8 s (SD 2.0) and 10.2 s (SD 3.9), respectively. The results of the adjusted repeated measures ANOVA suggested that there was a statistically significant interaction between MRT group and Wave (P = 0.023, η2p = 0.002). Interpretation: TILDA participants in the slower MRT group seemed to have faster mobility decline, but this effect was statistically and clinically small. Funding: TILDA is funded by Atlantic Philanthropies, the Irish Department of Health and Irish Life. Roman Romero-Ortuno is funded by Science Foundation Ireland (grant number 18/FRL/6188).http://www.sciencedirect.com/science/article/pii/S258953702030420XChoice reaction timeTime Up and GoCognitionMobilityLongitudinal study |
| spellingShingle | Renuka Chintapalli Roman Romero-Ortuno Choice reaction time and subsequent mobility decline: Prospective observational findings from The Irish Longitudinal Study on Ageing (TILDA) EClinicalMedicine Choice reaction time Time Up and Go Cognition Mobility Longitudinal study |
| title | Choice reaction time and subsequent mobility decline: Prospective observational findings from The Irish Longitudinal Study on Ageing (TILDA) |
| title_full | Choice reaction time and subsequent mobility decline: Prospective observational findings from The Irish Longitudinal Study on Ageing (TILDA) |
| title_fullStr | Choice reaction time and subsequent mobility decline: Prospective observational findings from The Irish Longitudinal Study on Ageing (TILDA) |
| title_full_unstemmed | Choice reaction time and subsequent mobility decline: Prospective observational findings from The Irish Longitudinal Study on Ageing (TILDA) |
| title_short | Choice reaction time and subsequent mobility decline: Prospective observational findings from The Irish Longitudinal Study on Ageing (TILDA) |
| title_sort | choice reaction time and subsequent mobility decline prospective observational findings from the irish longitudinal study on ageing tilda |
| topic | Choice reaction time Time Up and Go Cognition Mobility Longitudinal study |
| url | http://www.sciencedirect.com/science/article/pii/S258953702030420X |
| work_keys_str_mv | AT renukachintapalli choicereactiontimeandsubsequentmobilitydeclineprospectiveobservationalfindingsfromtheirishlongitudinalstudyonageingtilda AT romanromeroortuno choicereactiontimeandsubsequentmobilitydeclineprospectiveobservationalfindingsfromtheirishlongitudinalstudyonageingtilda |