Functional Status Following Pulmonary Rehabilitation: Responders and Non-Responders
The 6 min walking test (6MWT) has been largely studied. Less is, however, known about responders and non-responders to pulmonary rehabilitation (PR) in other meaningful activities. We explored responders and non-responders and the predictors of response to PR in the 1 min sit-to-stand test (1 min ST...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/3/518 |
| _version_ | 1797487013583126528 |
|---|---|
| author | Sara Souto-Miranda Maria A. Mendes João Cravo Lília Andrade Martijn A. Spruit Alda Marques |
| author_facet | Sara Souto-Miranda Maria A. Mendes João Cravo Lília Andrade Martijn A. Spruit Alda Marques |
| author_sort | Sara Souto-Miranda |
| collection | DOAJ |
| description | The 6 min walking test (6MWT) has been largely studied. Less is, however, known about responders and non-responders to pulmonary rehabilitation (PR) in other meaningful activities. We explored responders and non-responders and the predictors of response to PR in the 1 min sit-to-stand test (1 min STS) and the 6MWT and compared both measures in classifying responders. An observational study was conducted with 121 people with chronic obstructive pulmonary disease (COPD). The functional status was assessed before and after PR. Baseline differences between responders and non-responders were tested with Mann–Whitney U, chi-square, or Fisher exact tests. Predictors were explored with binary logistic regressions. Agreement between both measures was assessed with chi-square, Cohen’s kappa, and McNemar tests. There were 54.5% and 57.0% of responders in the 1 min STS and the 6MWT, respectively. The proportion of responders was significantly different (<i>p</i> = 0.048), with a small agreement between the measures (kappa = 0.180; <i>p</i> = 0.048). The baseline 6MWT was the only significant predictor of response in the 6MWT (OR = 0.995; pseudo-r2 = 0.117; <i>p</i> < 0.001). No significant predictors were found for the 1 min STS. A large number of non-responders in terms of functional status exist. The 1 min STS and the 6MWT should not be used interchangeably. Future studies should explore the added benefit of personalizing PR to this outcome and investigate other potential predictors. |
| first_indexed | 2024-03-09T23:42:38Z |
| format | Article |
| id | doaj.art-2084d49c14534a72a19162d7d8306524 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:42:38Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2084d49c14534a72a19162d7d83065242023-11-23T16:49:41ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111351810.3390/jcm11030518Functional Status Following Pulmonary Rehabilitation: Responders and Non-RespondersSara Souto-Miranda0Maria A. Mendes1João Cravo2Lília Andrade3Martijn A. Spruit4Alda Marques5Lab3R-Respiratory Research and Rehabilitation Laboratory, and Institute of Biomedicine (iBiMED), School of Health Sciences (ESSUA), University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Pulmonology, Centro Hospitalar do Baixo Vouga, E.P.E., 3810-164 Aveiro, PortugalDepartment of Pulmonology, Centro Hospitalar do Baixo Vouga, E.P.E., 3810-164 Aveiro, PortugalDepartment of Pulmonology, Centro Hospitalar do Baixo Vouga, E.P.E., 3810-164 Aveiro, PortugalDepartment of Respiratory Medicine, Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The NetherlandsLab3R-Respiratory Research and Rehabilitation Laboratory, and Institute of Biomedicine (iBiMED), School of Health Sciences (ESSUA), University of Aveiro, 3810-193 Aveiro, PortugalThe 6 min walking test (6MWT) has been largely studied. Less is, however, known about responders and non-responders to pulmonary rehabilitation (PR) in other meaningful activities. We explored responders and non-responders and the predictors of response to PR in the 1 min sit-to-stand test (1 min STS) and the 6MWT and compared both measures in classifying responders. An observational study was conducted with 121 people with chronic obstructive pulmonary disease (COPD). The functional status was assessed before and after PR. Baseline differences between responders and non-responders were tested with Mann–Whitney U, chi-square, or Fisher exact tests. Predictors were explored with binary logistic regressions. Agreement between both measures was assessed with chi-square, Cohen’s kappa, and McNemar tests. There were 54.5% and 57.0% of responders in the 1 min STS and the 6MWT, respectively. The proportion of responders was significantly different (<i>p</i> = 0.048), with a small agreement between the measures (kappa = 0.180; <i>p</i> = 0.048). The baseline 6MWT was the only significant predictor of response in the 6MWT (OR = 0.995; pseudo-r2 = 0.117; <i>p</i> < 0.001). No significant predictors were found for the 1 min STS. A large number of non-responders in terms of functional status exist. The 1 min STS and the 6MWT should not be used interchangeably. Future studies should explore the added benefit of personalizing PR to this outcome and investigate other potential predictors.https://www.mdpi.com/2077-0383/11/3/518functional statusCOPDpulmonary rehabilitationresponder analysis |
| spellingShingle | Sara Souto-Miranda Maria A. Mendes João Cravo Lília Andrade Martijn A. Spruit Alda Marques Functional Status Following Pulmonary Rehabilitation: Responders and Non-Responders Journal of Clinical Medicine functional status COPD pulmonary rehabilitation responder analysis |
| title | Functional Status Following Pulmonary Rehabilitation: Responders and Non-Responders |
| title_full | Functional Status Following Pulmonary Rehabilitation: Responders and Non-Responders |
| title_fullStr | Functional Status Following Pulmonary Rehabilitation: Responders and Non-Responders |
| title_full_unstemmed | Functional Status Following Pulmonary Rehabilitation: Responders and Non-Responders |
| title_short | Functional Status Following Pulmonary Rehabilitation: Responders and Non-Responders |
| title_sort | functional status following pulmonary rehabilitation responders and non responders |
| topic | functional status COPD pulmonary rehabilitation responder analysis |
| url | https://www.mdpi.com/2077-0383/11/3/518 |
| work_keys_str_mv | AT sarasoutomiranda functionalstatusfollowingpulmonaryrehabilitationrespondersandnonresponders AT mariaamendes functionalstatusfollowingpulmonaryrehabilitationrespondersandnonresponders AT joaocravo functionalstatusfollowingpulmonaryrehabilitationrespondersandnonresponders AT liliaandrade functionalstatusfollowingpulmonaryrehabilitationrespondersandnonresponders AT martijnaspruit functionalstatusfollowingpulmonaryrehabilitationrespondersandnonresponders AT aldamarques functionalstatusfollowingpulmonaryrehabilitationrespondersandnonresponders |